Dinucleoside polyphosphates act as 5′-RNA caps in bacteria

Nicotinamide adenine dinucleotide and coenzyme A serve as a 5′-cap of prokaryotic RNA. Here the authors report that methylated and non-methylated dinucleoside polyphosphates (Np n Ns) exist as Escherichia coli RNA caps which can be cleaved by 5′-pyrophosphohydrolase (RppH) and bis(5′-nucleosyl)-tetr...

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Autores principales: Oldřich Hudeček, Roberto Benoni, Paul E. Reyes-Gutierrez, Martin Culka, Hana Šanderová, Martin Hubálek, Lubomír Rulíšek, Josef Cvačka, Libor Krásný, Hana Cahová
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Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/a626bb909a284b82ac5da5fc2819c265
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spelling oai:doaj.org-article:a626bb909a284b82ac5da5fc2819c2652021-12-02T15:37:09ZDinucleoside polyphosphates act as 5′-RNA caps in bacteria10.1038/s41467-020-14896-82041-1723https://doaj.org/article/a626bb909a284b82ac5da5fc2819c2652020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14896-8https://doaj.org/toc/2041-1723Nicotinamide adenine dinucleotide and coenzyme A serve as a 5′-cap of prokaryotic RNA. Here the authors report that methylated and non-methylated dinucleoside polyphosphates (Np n Ns) exist as Escherichia coli RNA caps which can be cleaved by 5′-pyrophosphohydrolase (RppH) and bis(5′-nucleosyl)-tetraphosphatase (ApaH).Oldřich HudečekRoberto BenoniPaul E. Reyes-GutierrezMartin CulkaHana ŠanderováMartin HubálekLubomír RulíšekJosef CvačkaLibor KrásnýHana CahováNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Oldřich Hudeček
Roberto Benoni
Paul E. Reyes-Gutierrez
Martin Culka
Hana Šanderová
Martin Hubálek
Lubomír Rulíšek
Josef Cvačka
Libor Krásný
Hana Cahová
Dinucleoside polyphosphates act as 5′-RNA caps in bacteria
description Nicotinamide adenine dinucleotide and coenzyme A serve as a 5′-cap of prokaryotic RNA. Here the authors report that methylated and non-methylated dinucleoside polyphosphates (Np n Ns) exist as Escherichia coli RNA caps which can be cleaved by 5′-pyrophosphohydrolase (RppH) and bis(5′-nucleosyl)-tetraphosphatase (ApaH).
format article
author Oldřich Hudeček
Roberto Benoni
Paul E. Reyes-Gutierrez
Martin Culka
Hana Šanderová
Martin Hubálek
Lubomír Rulíšek
Josef Cvačka
Libor Krásný
Hana Cahová
author_facet Oldřich Hudeček
Roberto Benoni
Paul E. Reyes-Gutierrez
Martin Culka
Hana Šanderová
Martin Hubálek
Lubomír Rulíšek
Josef Cvačka
Libor Krásný
Hana Cahová
author_sort Oldřich Hudeček
title Dinucleoside polyphosphates act as 5′-RNA caps in bacteria
title_short Dinucleoside polyphosphates act as 5′-RNA caps in bacteria
title_full Dinucleoside polyphosphates act as 5′-RNA caps in bacteria
title_fullStr Dinucleoside polyphosphates act as 5′-RNA caps in bacteria
title_full_unstemmed Dinucleoside polyphosphates act as 5′-RNA caps in bacteria
title_sort dinucleoside polyphosphates act as 5′-rna caps in bacteria
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/a626bb909a284b82ac5da5fc2819c265
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