Morpho-molecular signal correlation between optical coherence tomography and Raman spectroscopy for superior image interpretation and clinical diagnosis

Abstract The combination of manifold optical imaging modalities resulting in multimodal optical systems allows to discover a larger number of biomarkers than using a single modality. The goal of multimodal imaging systems is to increase the diagnostic performance through the combination of complemen...

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Autores principales:	Iwan W. Schie, Fabian Placzek, Florian Knorr, Eliana Cordero, Lara M. Wurster, Gregers G. Hermann, Karin Mogensen, Thomas Hasselager, Wolfgang Drexler, Jürgen Popp, Rainer A. Leitgeb
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a62849cb59a744e9b990f15d86b86221
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spelling	oai:doaj.org-article:a62849cb59a744e9b990f15d86b862212021-12-02T15:36:13ZMorpho-molecular signal correlation between optical coherence tomography and Raman spectroscopy for superior image interpretation and clinical diagnosis10.1038/s41598-021-89188-22045-2322https://doaj.org/article/a62849cb59a744e9b990f15d86b862212021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89188-2https://doaj.org/toc/2045-2322Abstract The combination of manifold optical imaging modalities resulting in multimodal optical systems allows to discover a larger number of biomarkers than using a single modality. The goal of multimodal imaging systems is to increase the diagnostic performance through the combination of complementary modalities, e.g. optical coherence tomography (OCT) and Raman spectroscopy (RS). The physical signal origins of OCT and RS are distinctly different, i.e. in OCT it is elastic back scattering of photons, due to a change in refractive index, while in RS it is the inelastic scattering between photons and molecules. Despite those diverse characteristics both modalities are also linked via scattering properties and molecular composition of tissue. Here, we investigate for the first time the relation of co-registered OCT and RS signals of human bladder tissue, to demonstrate that the signals of these complementary modalities are inherently intertwined, enabling a direct but more importantly improved interpretation and better understanding of the other modality. This work demonstrates that the benefit for using two complementary imaging approaches is, not only the increased diagnostic value, but the increased information and better understanding of the signal origins of both modalities. This evaluation confirms the advantages for using multimodal imaging systems and also paves the way for significant further improved understanding and clinically interpretation of both modalities in the future.Iwan W. SchieFabian PlaczekFlorian KnorrEliana CorderoLara M. WursterGregers G. HermannKarin MogensenThomas HasselagerWolfgang DrexlerJürgen PoppRainer A. LeitgebNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Iwan W. Schie Fabian Placzek Florian Knorr Eliana Cordero Lara M. Wurster Gregers G. Hermann Karin Mogensen Thomas Hasselager Wolfgang Drexler Jürgen Popp Rainer A. Leitgeb Morpho-molecular signal correlation between optical coherence tomography and Raman spectroscopy for superior image interpretation and clinical diagnosis
description	Abstract The combination of manifold optical imaging modalities resulting in multimodal optical systems allows to discover a larger number of biomarkers than using a single modality. The goal of multimodal imaging systems is to increase the diagnostic performance through the combination of complementary modalities, e.g. optical coherence tomography (OCT) and Raman spectroscopy (RS). The physical signal origins of OCT and RS are distinctly different, i.e. in OCT it is elastic back scattering of photons, due to a change in refractive index, while in RS it is the inelastic scattering between photons and molecules. Despite those diverse characteristics both modalities are also linked via scattering properties and molecular composition of tissue. Here, we investigate for the first time the relation of co-registered OCT and RS signals of human bladder tissue, to demonstrate that the signals of these complementary modalities are inherently intertwined, enabling a direct but more importantly improved interpretation and better understanding of the other modality. This work demonstrates that the benefit for using two complementary imaging approaches is, not only the increased diagnostic value, but the increased information and better understanding of the signal origins of both modalities. This evaluation confirms the advantages for using multimodal imaging systems and also paves the way for significant further improved understanding and clinically interpretation of both modalities in the future.
format	article
author	Iwan W. Schie Fabian Placzek Florian Knorr Eliana Cordero Lara M. Wurster Gregers G. Hermann Karin Mogensen Thomas Hasselager Wolfgang Drexler Jürgen Popp Rainer A. Leitgeb
author_facet	Iwan W. Schie Fabian Placzek Florian Knorr Eliana Cordero Lara M. Wurster Gregers G. Hermann Karin Mogensen Thomas Hasselager Wolfgang Drexler Jürgen Popp Rainer A. Leitgeb
author_sort	Iwan W. Schie
title	Morpho-molecular signal correlation between optical coherence tomography and Raman spectroscopy for superior image interpretation and clinical diagnosis
title_short	Morpho-molecular signal correlation between optical coherence tomography and Raman spectroscopy for superior image interpretation and clinical diagnosis
title_full	Morpho-molecular signal correlation between optical coherence tomography and Raman spectroscopy for superior image interpretation and clinical diagnosis
title_fullStr	Morpho-molecular signal correlation between optical coherence tomography and Raman spectroscopy for superior image interpretation and clinical diagnosis
title_full_unstemmed	Morpho-molecular signal correlation between optical coherence tomography and Raman spectroscopy for superior image interpretation and clinical diagnosis
title_sort	morpho-molecular signal correlation between optical coherence tomography and raman spectroscopy for superior image interpretation and clinical diagnosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a62849cb59a744e9b990f15d86b86221
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Morpho-molecular signal correlation between optical coherence tomography and Raman spectroscopy for superior image interpretation and clinical diagnosis

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