Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson’s disease

Mitochondrial and lysosomal dysfunction are central to Parkinson’s disease (PD) pathogenesis. Here, the authors show mitochondrial dsDNA in the cytosol in cellular and Zebrafish models of PD induces cytotoxicity and neurodegeneration; knock-down of IFI16, a cytosolic dsDNA sensor, rescues cytotoxici...

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Autores principales:	Hideaki Matsui, Junko Ito, Noriko Matsui, Tamayo Uechi, Osamu Onodera, Akiyoshi Kakita
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a628dfb33fe649838ef8fb28d3fa0336
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spelling	oai:doaj.org-article:a628dfb33fe649838ef8fb28d3fa03362021-12-02T14:47:29ZCytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson’s disease10.1038/s41467-021-23452-x2041-1723https://doaj.org/article/a628dfb33fe649838ef8fb28d3fa03362021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23452-xhttps://doaj.org/toc/2041-1723Mitochondrial and lysosomal dysfunction are central to Parkinson’s disease (PD) pathogenesis. Here, the authors show mitochondrial dsDNA in the cytosol in cellular and Zebrafish models of PD induces cytotoxicity and neurodegeneration; knock-down of IFI16, a cytosolic dsDNA sensor, rescues cytotoxicity, as does overexpression of lysosomal DNAse II.Hideaki MatsuiJunko ItoNoriko MatsuiTamayo UechiOsamu OnoderaAkiyoshi KakitaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hideaki Matsui Junko Ito Noriko Matsui Tamayo Uechi Osamu Onodera Akiyoshi Kakita Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson’s disease
description	Mitochondrial and lysosomal dysfunction are central to Parkinson’s disease (PD) pathogenesis. Here, the authors show mitochondrial dsDNA in the cytosol in cellular and Zebrafish models of PD induces cytotoxicity and neurodegeneration; knock-down of IFI16, a cytosolic dsDNA sensor, rescues cytotoxicity, as does overexpression of lysosomal DNAse II.
format	article
author	Hideaki Matsui Junko Ito Noriko Matsui Tamayo Uechi Osamu Onodera Akiyoshi Kakita
author_facet	Hideaki Matsui Junko Ito Noriko Matsui Tamayo Uechi Osamu Onodera Akiyoshi Kakita
author_sort	Hideaki Matsui
title	Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson’s disease
title_short	Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson’s disease
title_full	Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson’s disease
title_fullStr	Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson’s disease
title_full_unstemmed	Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson’s disease
title_sort	cytosolic dsdna of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a628dfb33fe649838ef8fb28d3fa0336
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_version_	1718389527721017344

Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson’s disease

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