Fiber-specific white matter alterations in early-stage tremor-dominant Parkinson’s disease

Fiber-specific white matter alterations in early-stage tremor-dominant Parkinson’s disease

Abstract Using a fixel-based analysis (FBA), we assessed the fiber-specific white matter (WM) alterations in nonmedicated patients with early-stage Parkinson’s disease (PD) with tremor-dominant (TD; n = 53; mean age, 61.7 ± 8.7 years) and postural instability and gait disorder (PIGD; n = 27; mean ag...

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Autores principales: Christina Andica, Koji Kamagata, Yuya Saito, Wataru Uchida, Shohei Fujita, Akifumi Hagiwara, Toshiaki Akashi, Akihiko Wada, Takashi Ogawa, Taku Hatano, Nobutaka Hattori, Shigeki Aoki
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/a62949e23bc44e2eb28679d9ca2f8462
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spelling oai:doaj.org-article:a62949e23bc44e2eb28679d9ca2f84622021-12-02T18:02:50ZFiber-specific white matter alterations in early-stage tremor-dominant Parkinson’s disease10.1038/s41531-021-00197-42373-8057https://doaj.org/article/a62949e23bc44e2eb28679d9ca2f84622021-06-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00197-4https://doaj.org/toc/2373-8057Abstract Using a fixel-based analysis (FBA), we assessed the fiber-specific white matter (WM) alterations in nonmedicated patients with early-stage Parkinson’s disease (PD) with tremor-dominant (TD; n = 53; mean age, 61.7 ± 8.7 years) and postural instability and gait disorder (PIGD; n = 27; mean age, 57.8 ± 8.1 years) motor subtypes and age- and sex-matched healthy controls (HC; n = 43; mean age, 61.6 ± 9.2 years) from Parkinson’s Progression Markers Initiative dataset. FBA revealed significantly increased macrostructural fiber cross section and a combination of fiber density and cross section metrics within the corticospinal tract in patients with TD-PD compared with HC. Nonetheless, no significant changes in FBA-derived metrics were found in patients with PIGD-PD compared with HC or patients with TD-PD. Our results may provide evidence of WM neural compensation mechanisms in patients with TD-PD marked by increases in fiber bundle size and the ability to relay information between brain regions.Christina AndicaKoji KamagataYuya SaitoWataru UchidaShohei FujitaAkifumi HagiwaraToshiaki AkashiAkihiko WadaTakashi OgawaTaku HatanoNobutaka HattoriShigeki AokiNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurology. Diseases of the nervous system
RC346-429
Christina Andica
Koji Kamagata
Yuya Saito
Wataru Uchida
Shohei Fujita
Akifumi Hagiwara
Toshiaki Akashi
Akihiko Wada
Takashi Ogawa
Taku Hatano
Nobutaka Hattori
Shigeki Aoki
Fiber-specific white matter alterations in early-stage tremor-dominant Parkinson’s disease
description Abstract Using a fixel-based analysis (FBA), we assessed the fiber-specific white matter (WM) alterations in nonmedicated patients with early-stage Parkinson’s disease (PD) with tremor-dominant (TD; n = 53; mean age, 61.7 ± 8.7 years) and postural instability and gait disorder (PIGD; n = 27; mean age, 57.8 ± 8.1 years) motor subtypes and age- and sex-matched healthy controls (HC; n = 43; mean age, 61.6 ± 9.2 years) from Parkinson’s Progression Markers Initiative dataset. FBA revealed significantly increased macrostructural fiber cross section and a combination of fiber density and cross section metrics within the corticospinal tract in patients with TD-PD compared with HC. Nonetheless, no significant changes in FBA-derived metrics were found in patients with PIGD-PD compared with HC or patients with TD-PD. Our results may provide evidence of WM neural compensation mechanisms in patients with TD-PD marked by increases in fiber bundle size and the ability to relay information between brain regions.
format article
author Christina Andica
Koji Kamagata
Yuya Saito
Wataru Uchida
Shohei Fujita
Akifumi Hagiwara
Toshiaki Akashi
Akihiko Wada
Takashi Ogawa
Taku Hatano
Nobutaka Hattori
Shigeki Aoki
author_facet Christina Andica
Koji Kamagata
Yuya Saito
Wataru Uchida
Shohei Fujita
Akifumi Hagiwara
Toshiaki Akashi
Akihiko Wada
Takashi Ogawa
Taku Hatano
Nobutaka Hattori
Shigeki Aoki
author_sort Christina Andica
title Fiber-specific white matter alterations in early-stage tremor-dominant Parkinson’s disease
title_short Fiber-specific white matter alterations in early-stage tremor-dominant Parkinson’s disease
title_full Fiber-specific white matter alterations in early-stage tremor-dominant Parkinson’s disease
title_fullStr Fiber-specific white matter alterations in early-stage tremor-dominant Parkinson’s disease
title_full_unstemmed Fiber-specific white matter alterations in early-stage tremor-dominant Parkinson’s disease
title_sort fiber-specific white matter alterations in early-stage tremor-dominant parkinson’s disease
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/a62949e23bc44e2eb28679d9ca2f8462
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