Comparative analysis of ear-hole closure identifies epimorphic regeneration as a discrete trait in mammals

The extent to which mammals and other vertebrates share similar mechanisms of tissue regeneration is unclear. Here, the authors use an ear punch assay in spiny mice, which regenerate fully, to show blastema formation and mesenchymal cell proliferation as cell cycle regulators p21 and p27 remain cyto...

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Autores principales:	Thomas R. Gawriluk, Jennifer Simkin, Katherine L. Thompson, Shishir K. Biswas, Zak Clare-Salzler, John M. Kimani, Stephen G. Kiama, Jeramiah J. Smith, Vanessa O. Ezenwa, Ashley W. Seifert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a62c412d3ea44cd58d19b2ec254d40bb
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spelling	oai:doaj.org-article:a62c412d3ea44cd58d19b2ec254d40bb2021-12-02T14:38:34ZComparative analysis of ear-hole closure identifies epimorphic regeneration as a discrete trait in mammals10.1038/ncomms111642041-1723https://doaj.org/article/a62c412d3ea44cd58d19b2ec254d40bb2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11164https://doaj.org/toc/2041-1723The extent to which mammals and other vertebrates share similar mechanisms of tissue regeneration is unclear. Here, the authors use an ear punch assay in spiny mice, which regenerate fully, to show blastema formation and mesenchymal cell proliferation as cell cycle regulators p21 and p27 remain cytoplasmic.Thomas R. GawrilukJennifer SimkinKatherine L. ThompsonShishir K. BiswasZak Clare-SalzlerJohn M. KimaniStephen G. KiamaJeramiah J. SmithVanessa O. EzenwaAshley W. SeifertNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas R. Gawriluk Jennifer Simkin Katherine L. Thompson Shishir K. Biswas Zak Clare-Salzler John M. Kimani Stephen G. Kiama Jeramiah J. Smith Vanessa O. Ezenwa Ashley W. Seifert Comparative analysis of ear-hole closure identifies epimorphic regeneration as a discrete trait in mammals
description	The extent to which mammals and other vertebrates share similar mechanisms of tissue regeneration is unclear. Here, the authors use an ear punch assay in spiny mice, which regenerate fully, to show blastema formation and mesenchymal cell proliferation as cell cycle regulators p21 and p27 remain cytoplasmic.
format	article
author	Thomas R. Gawriluk Jennifer Simkin Katherine L. Thompson Shishir K. Biswas Zak Clare-Salzler John M. Kimani Stephen G. Kiama Jeramiah J. Smith Vanessa O. Ezenwa Ashley W. Seifert
author_facet	Thomas R. Gawriluk Jennifer Simkin Katherine L. Thompson Shishir K. Biswas Zak Clare-Salzler John M. Kimani Stephen G. Kiama Jeramiah J. Smith Vanessa O. Ezenwa Ashley W. Seifert
author_sort	Thomas R. Gawriluk
title	Comparative analysis of ear-hole closure identifies epimorphic regeneration as a discrete trait in mammals
title_short	Comparative analysis of ear-hole closure identifies epimorphic regeneration as a discrete trait in mammals
title_full	Comparative analysis of ear-hole closure identifies epimorphic regeneration as a discrete trait in mammals
title_fullStr	Comparative analysis of ear-hole closure identifies epimorphic regeneration as a discrete trait in mammals
title_full_unstemmed	Comparative analysis of ear-hole closure identifies epimorphic regeneration as a discrete trait in mammals
title_sort	comparative analysis of ear-hole closure identifies epimorphic regeneration as a discrete trait in mammals
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a62c412d3ea44cd58d19b2ec254d40bb
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Comparative analysis of ear-hole closure identifies epimorphic regeneration as a discrete trait in mammals

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