Hepatic TET3 contributes to type-2 diabetes by inducing the HNF4α fetal isoform

The HNF4α gene contains two promoters, which are thought to be active in the fetal and adult liver, the latter contributing to hepatic glucose production. Here the authors show that the fetal isoform of HNF4a is induced in mouse livers upon fasting and in type-2 diabetes in a manner regulated by TET...

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Autores principales:	Da Li, Tiefeng Cao, Xiaoli Sun, Sungho Jin, Di Xie, Xinmei Huang, Xiaoyong Yang, Gordon G. Carmichael, Hugh S. Taylor, Sabrina Diano, Yingqun Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a62c4bcfbe29410f87a5231239c340ac
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spelling	oai:doaj.org-article:a62c4bcfbe29410f87a5231239c340ac2021-12-02T16:56:48ZHepatic TET3 contributes to type-2 diabetes by inducing the HNF4α fetal isoform10.1038/s41467-019-14185-z2041-1723https://doaj.org/article/a62c4bcfbe29410f87a5231239c340ac2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14185-zhttps://doaj.org/toc/2041-1723The HNF4α gene contains two promoters, which are thought to be active in the fetal and adult liver, the latter contributing to hepatic glucose production. Here the authors show that the fetal isoform of HNF4a is induced in mouse livers upon fasting and in type-2 diabetes in a manner regulated by TET3.Da LiTiefeng CaoXiaoli SunSungho JinDi XieXinmei HuangXiaoyong YangGordon G. CarmichaelHugh S. TaylorSabrina DianoYingqun HuangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Da Li Tiefeng Cao Xiaoli Sun Sungho Jin Di Xie Xinmei Huang Xiaoyong Yang Gordon G. Carmichael Hugh S. Taylor Sabrina Diano Yingqun Huang Hepatic TET3 contributes to type-2 diabetes by inducing the HNF4α fetal isoform
description	The HNF4α gene contains two promoters, which are thought to be active in the fetal and adult liver, the latter contributing to hepatic glucose production. Here the authors show that the fetal isoform of HNF4a is induced in mouse livers upon fasting and in type-2 diabetes in a manner regulated by TET3.
format	article
author	Da Li Tiefeng Cao Xiaoli Sun Sungho Jin Di Xie Xinmei Huang Xiaoyong Yang Gordon G. Carmichael Hugh S. Taylor Sabrina Diano Yingqun Huang
author_facet	Da Li Tiefeng Cao Xiaoli Sun Sungho Jin Di Xie Xinmei Huang Xiaoyong Yang Gordon G. Carmichael Hugh S. Taylor Sabrina Diano Yingqun Huang
author_sort	Da Li
title	Hepatic TET3 contributes to type-2 diabetes by inducing the HNF4α fetal isoform
title_short	Hepatic TET3 contributes to type-2 diabetes by inducing the HNF4α fetal isoform
title_full	Hepatic TET3 contributes to type-2 diabetes by inducing the HNF4α fetal isoform
title_fullStr	Hepatic TET3 contributes to type-2 diabetes by inducing the HNF4α fetal isoform
title_full_unstemmed	Hepatic TET3 contributes to type-2 diabetes by inducing the HNF4α fetal isoform
title_sort	hepatic tet3 contributes to type-2 diabetes by inducing the hnf4α fetal isoform
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a62c4bcfbe29410f87a5231239c340ac
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Hepatic TET3 contributes to type-2 diabetes by inducing the HNF4α fetal isoform

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