Profiling variable-number tandem repeat variation across populations using repeat-pangenome graphs

Variable number tandem repeats (VNTRs) are difficult to analyze by short-read sequencing in disease studies. Here, the authors describe a VNTR mapping strategy for short-read analyses using a repeat pangenome graph. This method will help elucidate the contribution of VNTRs to diversity and disease.

Guardado en:

Detalles Bibliográficos
Autores principales:	Tsung-Yu Lu, The Human Genome Structural Variation Consortium, Mark J. P. Chaisson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a62e10329da24fef97c378d11249445d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a62e10329da24fef97c378d11249445d
record_format	dspace
spelling	oai:doaj.org-article:a62e10329da24fef97c378d11249445d2021-12-02T17:01:15ZProfiling variable-number tandem repeat variation across populations using repeat-pangenome graphs10.1038/s41467-021-24378-02041-1723https://doaj.org/article/a62e10329da24fef97c378d11249445d2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24378-0https://doaj.org/toc/2041-1723Variable number tandem repeats (VNTRs) are difficult to analyze by short-read sequencing in disease studies. Here, the authors describe a VNTR mapping strategy for short-read analyses using a repeat pangenome graph. This method will help elucidate the contribution of VNTRs to diversity and disease.Tsung-Yu LuThe Human Genome Structural Variation ConsortiumMark J. P. ChaissonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tsung-Yu Lu The Human Genome Structural Variation Consortium Mark J. P. Chaisson Profiling variable-number tandem repeat variation across populations using repeat-pangenome graphs
description	Variable number tandem repeats (VNTRs) are difficult to analyze by short-read sequencing in disease studies. Here, the authors describe a VNTR mapping strategy for short-read analyses using a repeat pangenome graph. This method will help elucidate the contribution of VNTRs to diversity and disease.
format	article
author	Tsung-Yu Lu The Human Genome Structural Variation Consortium Mark J. P. Chaisson
author_facet	Tsung-Yu Lu The Human Genome Structural Variation Consortium Mark J. P. Chaisson
author_sort	Tsung-Yu Lu
title	Profiling variable-number tandem repeat variation across populations using repeat-pangenome graphs
title_short	Profiling variable-number tandem repeat variation across populations using repeat-pangenome graphs
title_full	Profiling variable-number tandem repeat variation across populations using repeat-pangenome graphs
title_fullStr	Profiling variable-number tandem repeat variation across populations using repeat-pangenome graphs
title_full_unstemmed	Profiling variable-number tandem repeat variation across populations using repeat-pangenome graphs
title_sort	profiling variable-number tandem repeat variation across populations using repeat-pangenome graphs
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a62e10329da24fef97c378d11249445d
work_keys_str_mv	AT tsungyulu profilingvariablenumbertandemrepeatvariationacrosspopulationsusingrepeatpangenomegraphs AT thehumangenomestructuralvariationconsortium profilingvariablenumbertandemrepeatvariationacrosspopulationsusingrepeatpangenomegraphs AT markjpchaisson profilingvariablenumbertandemrepeatvariationacrosspopulationsusingrepeatpangenomegraphs
_version_	1718382228370620416

Profiling variable-number tandem repeat variation across populations using repeat-pangenome graphs

Ejemplares similares