Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation

Denervation of muscle fibres induces muscle atrophy, via mechanisms that remain unclear. Here, the authors show that binding of acetylcoline to its receptor at the neuromuscular junction represses the expression of connexins 43 and 45, which promote atrophy, and is sufficient to prevent denervation-...

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Autores principales:	Bruno A. Cisterna, Aníbal A. Vargas, Carlos Puebla, Paola Fernández, Rosalba Escamilla, Carlos F. Lagos, María F. Matus, Cristian Vilos, Luis A. Cea, Esteban Barnafi, Hugo Gaete, Daniel F. Escobar, Christopher P. Cardozo, Juan C. Sáez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a63161896eea490ebe56ede16c508aaf
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spelling	oai:doaj.org-article:a63161896eea490ebe56ede16c508aaf2021-12-02T14:41:15ZActive acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation10.1038/s41467-019-14063-82041-1723https://doaj.org/article/a63161896eea490ebe56ede16c508aaf2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14063-8https://doaj.org/toc/2041-1723Denervation of muscle fibres induces muscle atrophy, via mechanisms that remain unclear. Here, the authors show that binding of acetylcoline to its receptor at the neuromuscular junction represses the expression of connexins 43 and 45, which promote atrophy, and is sufficient to prevent denervation-induced loss of myofibre mass.Bruno A. CisternaAníbal A. VargasCarlos PueblaPaola FernándezRosalba EscamillaCarlos F. LagosMaría F. MatusCristian VilosLuis A. CeaEsteban BarnafiHugo GaeteDaniel F. EscobarChristopher P. CardozoJuan C. SáezNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bruno A. Cisterna Aníbal A. Vargas Carlos Puebla Paola Fernández Rosalba Escamilla Carlos F. Lagos María F. Matus Cristian Vilos Luis A. Cea Esteban Barnafi Hugo Gaete Daniel F. Escobar Christopher P. Cardozo Juan C. Sáez Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation
description	Denervation of muscle fibres induces muscle atrophy, via mechanisms that remain unclear. Here, the authors show that binding of acetylcoline to its receptor at the neuromuscular junction represses the expression of connexins 43 and 45, which promote atrophy, and is sufficient to prevent denervation-induced loss of myofibre mass.
format	article
author	Bruno A. Cisterna Aníbal A. Vargas Carlos Puebla Paola Fernández Rosalba Escamilla Carlos F. Lagos María F. Matus Cristian Vilos Luis A. Cea Esteban Barnafi Hugo Gaete Daniel F. Escobar Christopher P. Cardozo Juan C. Sáez
author_facet	Bruno A. Cisterna Aníbal A. Vargas Carlos Puebla Paola Fernández Rosalba Escamilla Carlos F. Lagos María F. Matus Cristian Vilos Luis A. Cea Esteban Barnafi Hugo Gaete Daniel F. Escobar Christopher P. Cardozo Juan C. Sáez
author_sort	Bruno A. Cisterna
title	Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation
title_short	Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation
title_full	Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation
title_fullStr	Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation
title_full_unstemmed	Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation
title_sort	active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a63161896eea490ebe56ede16c508aaf
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Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation

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