EVALUATION OF INTERDEPENDENCE BETWEEN γδT-CELL LEVELS AND CD3+CD4+ T-LYMPHOCYTE CONTENTS IN HIV-INFECTED PATIENTS

We have performed immunophenotyping of lymphocytes in 150 HIV-positive patients, by means of flow cytometry. All the persons under study were classified into three groups, depending on absolute contents of CD3+CD4+T-lymphocytes in peripheral blood, according to HIV infection staging in adults and ad...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A. V. Zurochka, T. V. Gavrilova, E. V. Shestakova, S. V. Kvyatkovskaya, T. V. Mirkina, V. A. Chereshnev
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	тγδ-lymphocytes hiv infection helper т cells cytotoxic t lymphocytes immunophenotyping Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a6318d2b33054418993008c900caa6d9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a6318d2b33054418993008c900caa6d9
record_format	dspace
spelling	oai:doaj.org-article:a6318d2b33054418993008c900caa6d92021-11-18T08:03:40ZEVALUATION OF INTERDEPENDENCE BETWEEN γδT-CELL LEVELS AND CD3+CD4+ T-LYMPHOCYTE CONTENTS IN HIV-INFECTED PATIENTS1563-06252313-741X10.15789/1563-0625-2010-4-5-425-428https://doaj.org/article/a6318d2b33054418993008c900caa6d92014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/356https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XWe have performed immunophenotyping of lymphocytes in 150 HIV-positive patients, by means of flow cytometry. All the persons under study were classified into three groups, depending on absolute contents of CD3+CD4+T-lymphocytes in peripheral blood, according to HIV infection staging in adults and adolescents, as amended by CDC (USA). It was revealed that, at each subsequent stage of disease, a decrease in absolute numbers of T-helpers is accompanied by drop in relative and absolute numbers of lymphocytes, as well as in total T-lymphocyte numbers, and decreased amounts of absolute cytotoxic T-lymphocytes levels, combined with increase in their relative contents, along with decreased CD3+CD4+/CD3+CD8+ ratio, diminished levels of double-positive subpopulation, decrease in relative and absolute levels of αβТ-lymphocytes and significant drop in absolute levels of γδТ-cells, while their relative amounts remained normal. These findings demonstrate a pattern typical to the absence of immunological reactions in response to antigens persisting in the organism.A. V. ZurochkaT. V. GavrilovaE. V. ShestakovaS. V. KvyatkovskayaT. V. MirkinaV. A. ChereshnevSPb RAACIarticleтγδ-lymphocyteshiv infectionhelper т cellscytotoxic t lymphocytesimmunophenotypingImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 4-5, Pp 425-428 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	тγδ-lymphocytes hiv infection helper т cells cytotoxic t lymphocytes immunophenotyping Immunologic diseases. Allergy RC581-607
spellingShingle	тγδ-lymphocytes hiv infection helper т cells cytotoxic t lymphocytes immunophenotyping Immunologic diseases. Allergy RC581-607 A. V. Zurochka T. V. Gavrilova E. V. Shestakova S. V. Kvyatkovskaya T. V. Mirkina V. A. Chereshnev EVALUATION OF INTERDEPENDENCE BETWEEN γδT-CELL LEVELS AND CD3+CD4+ T-LYMPHOCYTE CONTENTS IN HIV-INFECTED PATIENTS
description	We have performed immunophenotyping of lymphocytes in 150 HIV-positive patients, by means of flow cytometry. All the persons under study were classified into three groups, depending on absolute contents of CD3+CD4+T-lymphocytes in peripheral blood, according to HIV infection staging in adults and adolescents, as amended by CDC (USA). It was revealed that, at each subsequent stage of disease, a decrease in absolute numbers of T-helpers is accompanied by drop in relative and absolute numbers of lymphocytes, as well as in total T-lymphocyte numbers, and decreased amounts of absolute cytotoxic T-lymphocytes levels, combined with increase in their relative contents, along with decreased CD3+CD4+/CD3+CD8+ ratio, diminished levels of double-positive subpopulation, decrease in relative and absolute levels of αβТ-lymphocytes and significant drop in absolute levels of γδТ-cells, while their relative amounts remained normal. These findings demonstrate a pattern typical to the absence of immunological reactions in response to antigens persisting in the organism.
format	article
author	A. V. Zurochka T. V. Gavrilova E. V. Shestakova S. V. Kvyatkovskaya T. V. Mirkina V. A. Chereshnev
author_facet	A. V. Zurochka T. V. Gavrilova E. V. Shestakova S. V. Kvyatkovskaya T. V. Mirkina V. A. Chereshnev
author_sort	A. V. Zurochka
title	EVALUATION OF INTERDEPENDENCE BETWEEN γδT-CELL LEVELS AND CD3+CD4+ T-LYMPHOCYTE CONTENTS IN HIV-INFECTED PATIENTS
title_short	EVALUATION OF INTERDEPENDENCE BETWEEN γδT-CELL LEVELS AND CD3+CD4+ T-LYMPHOCYTE CONTENTS IN HIV-INFECTED PATIENTS
title_full	EVALUATION OF INTERDEPENDENCE BETWEEN γδT-CELL LEVELS AND CD3+CD4+ T-LYMPHOCYTE CONTENTS IN HIV-INFECTED PATIENTS
title_fullStr	EVALUATION OF INTERDEPENDENCE BETWEEN γδT-CELL LEVELS AND CD3+CD4+ T-LYMPHOCYTE CONTENTS IN HIV-INFECTED PATIENTS
title_full_unstemmed	EVALUATION OF INTERDEPENDENCE BETWEEN γδT-CELL LEVELS AND CD3+CD4+ T-LYMPHOCYTE CONTENTS IN HIV-INFECTED PATIENTS
title_sort	evaluation of interdependence between γδt-cell levels and cd3+cd4+ t-lymphocyte contents in hiv-infected patients
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/a6318d2b33054418993008c900caa6d9
work_keys_str_mv	AT avzurochka evaluationofinterdependencebetweengdtcelllevelsandcd3cd4tlymphocytecontentsinhivinfectedpatients AT tvgavrilova evaluationofinterdependencebetweengdtcelllevelsandcd3cd4tlymphocytecontentsinhivinfectedpatients AT evshestakova evaluationofinterdependencebetweengdtcelllevelsandcd3cd4tlymphocytecontentsinhivinfectedpatients AT svkvyatkovskaya evaluationofinterdependencebetweengdtcelllevelsandcd3cd4tlymphocytecontentsinhivinfectedpatients AT tvmirkina evaluationofinterdependencebetweengdtcelllevelsandcd3cd4tlymphocytecontentsinhivinfectedpatients AT vachereshnev evaluationofinterdependencebetweengdtcelllevelsandcd3cd4tlymphocytecontentsinhivinfectedpatients
_version_	1718422497297170432

EVALUATION OF INTERDEPENDENCE BETWEEN γδT-CELL LEVELS AND CD3+CD4+ T-LYMPHOCYTE CONTENTS IN HIV-INFECTED PATIENTS

Ejemplares similares