IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation

Macrophage activation is synergistically controlled by lipopolysaccharide (LPS) and interferon-γ (IFN-γ). Here the authors show that IFN-γ promotes macrophage activation not only by activating STAT1-dependent genes, but also by suppressing STAT3-dependent negative feedback regulation downstream of L...

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Autores principales:	Kyuho Kang, Mahesh Bachu, Sung Ho Park, Keunsoo Kang, Seyeon Bae, Kyung-Hyun Park-Min, Lionel B. Ivashkiv
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a631a2760ed54421b4271c48a107d9ac
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spelling	oai:doaj.org-article:a631a2760ed54421b4271c48a107d9ac2021-12-02T14:38:39ZIFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation10.1038/s41467-019-11147-32041-1723https://doaj.org/article/a631a2760ed54421b4271c48a107d9ac2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11147-3https://doaj.org/toc/2041-1723Macrophage activation is synergistically controlled by lipopolysaccharide (LPS) and interferon-γ (IFN-γ). Here the authors show that IFN-γ promotes macrophage activation not only by activating STAT1-dependent genes, but also by suppressing STAT3-dependent negative feedback regulation downstream of LPS signaling.Kyuho KangMahesh BachuSung Ho ParkKeunsoo KangSeyeon BaeKyung-Hyun Park-MinLionel B. IvashkivNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kyuho Kang Mahesh Bachu Sung Ho Park Keunsoo Kang Seyeon Bae Kyung-Hyun Park-Min Lionel B. Ivashkiv IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation
description	Macrophage activation is synergistically controlled by lipopolysaccharide (LPS) and interferon-γ (IFN-γ). Here the authors show that IFN-γ promotes macrophage activation not only by activating STAT1-dependent genes, but also by suppressing STAT3-dependent negative feedback regulation downstream of LPS signaling.
format	article
author	Kyuho Kang Mahesh Bachu Sung Ho Park Keunsoo Kang Seyeon Bae Kyung-Hyun Park-Min Lionel B. Ivashkiv
author_facet	Kyuho Kang Mahesh Bachu Sung Ho Park Keunsoo Kang Seyeon Bae Kyung-Hyun Park-Min Lionel B. Ivashkiv
author_sort	Kyuho Kang
title	IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation
title_short	IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation
title_full	IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation
title_fullStr	IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation
title_full_unstemmed	IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation
title_sort	ifn-γ selectively suppresses a subset of tlr4-activated genes and enhancers to potentiate macrophage activation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a631a2760ed54421b4271c48a107d9ac
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IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation

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