Cancer cells with trapped nuclei cut their way through the extracellular matrix

Abstract When an invading cancer cell attempts to pass through a hole in the extracellular matrix (ECM) which is too small for its nucleus, this generates physical tension. This tension is sensed by a nucleus–centrosome connection that activates trafficking of endosomal vesicles containing the matri...

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Autores principales:	Emmanuel Dornier, Jim C. Norman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a6353e4678504b70b9f1e274bcf172db
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spelling	oai:doaj.org-article:a6353e4678504b70b9f1e274bcf172db2021-12-02T14:38:53ZCancer cells with trapped nuclei cut their way through the extracellular matrix10.1038/s41467-018-06351-62041-1723https://doaj.org/article/a6353e4678504b70b9f1e274bcf172db2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06351-6https://doaj.org/toc/2041-1723Abstract When an invading cancer cell attempts to pass through a hole in the extracellular matrix (ECM) which is too small for its nucleus, this generates physical tension. This tension is sensed by a nucleus–centrosome connection that activates trafficking of endosomal vesicles containing the matrix metalloprotease, MT1-MMP1 to the site of constraint. Recent evidence shows how focussed ECM degradation relieves the constraint and allows cancer cells to continue invading.Emmanuel DornierJim C. NormanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-3 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emmanuel Dornier Jim C. Norman Cancer cells with trapped nuclei cut their way through the extracellular matrix
description	Abstract When an invading cancer cell attempts to pass through a hole in the extracellular matrix (ECM) which is too small for its nucleus, this generates physical tension. This tension is sensed by a nucleus–centrosome connection that activates trafficking of endosomal vesicles containing the matrix metalloprotease, MT1-MMP1 to the site of constraint. Recent evidence shows how focussed ECM degradation relieves the constraint and allows cancer cells to continue invading.
format	article
author	Emmanuel Dornier Jim C. Norman
author_facet	Emmanuel Dornier Jim C. Norman
author_sort	Emmanuel Dornier
title	Cancer cells with trapped nuclei cut their way through the extracellular matrix
title_short	Cancer cells with trapped nuclei cut their way through the extracellular matrix
title_full	Cancer cells with trapped nuclei cut their way through the extracellular matrix
title_fullStr	Cancer cells with trapped nuclei cut their way through the extracellular matrix
title_full_unstemmed	Cancer cells with trapped nuclei cut their way through the extracellular matrix
title_sort	cancer cells with trapped nuclei cut their way through the extracellular matrix
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a6353e4678504b70b9f1e274bcf172db
work_keys_str_mv	AT emmanueldornier cancercellswithtrappednucleicuttheirwaythroughtheextracellularmatrix AT jimcnorman cancercellswithtrappednucleicuttheirwaythroughtheextracellularmatrix
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Cancer cells with trapped nuclei cut their way through the extracellular matrix

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