Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise

Reactive oxygen species (ROS) stimulate GLUT4-mediated glucose transport following contraction of isolated muscle, but it is not clear if this occurs in vivo. Here, the authors show in human volunteers that exercise induces ROS increase in muscle and, using loss of-function animal models, they demon...

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Autores principales:	Carlos Henríquez-Olguin, Jonas R. Knudsen, Steffen H. Raun, Zhencheng Li, Emilie Dalbram, Jonas T. Treebak, Lykke Sylow, Rikard Holmdahl, Erik A. Richter, Enrique Jaimovich, Thomas E. Jensen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a635b493f521447c82852adb296d2252
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spelling	oai:doaj.org-article:a635b493f521447c82852adb296d22522021-12-02T14:39:21ZCytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise10.1038/s41467-019-12523-92041-1723https://doaj.org/article/a635b493f521447c82852adb296d22522019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12523-9https://doaj.org/toc/2041-1723Reactive oxygen species (ROS) stimulate GLUT4-mediated glucose transport following contraction of isolated muscle, but it is not clear if this occurs in vivo. Here, the authors show in human volunteers that exercise induces ROS increase in muscle and, using loss of-function animal models, they demonstrate that NOX2 is a major ROS source required to stimulate glucose uptake during exercise.Carlos Henríquez-OlguinJonas R. KnudsenSteffen H. RaunZhencheng LiEmilie DalbramJonas T. TreebakLykke SylowRikard HolmdahlErik A. RichterEnrique JaimovichThomas E. JensenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carlos Henríquez-Olguin Jonas R. Knudsen Steffen H. Raun Zhencheng Li Emilie Dalbram Jonas T. Treebak Lykke Sylow Rikard Holmdahl Erik A. Richter Enrique Jaimovich Thomas E. Jensen Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise
description	Reactive oxygen species (ROS) stimulate GLUT4-mediated glucose transport following contraction of isolated muscle, but it is not clear if this occurs in vivo. Here, the authors show in human volunteers that exercise induces ROS increase in muscle and, using loss of-function animal models, they demonstrate that NOX2 is a major ROS source required to stimulate glucose uptake during exercise.
format	article
author	Carlos Henríquez-Olguin Jonas R. Knudsen Steffen H. Raun Zhencheng Li Emilie Dalbram Jonas T. Treebak Lykke Sylow Rikard Holmdahl Erik A. Richter Enrique Jaimovich Thomas E. Jensen
author_facet	Carlos Henríquez-Olguin Jonas R. Knudsen Steffen H. Raun Zhencheng Li Emilie Dalbram Jonas T. Treebak Lykke Sylow Rikard Holmdahl Erik A. Richter Enrique Jaimovich Thomas E. Jensen
author_sort	Carlos Henríquez-Olguin
title	Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise
title_short	Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise
title_full	Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise
title_fullStr	Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise
title_full_unstemmed	Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise
title_sort	cytosolic ros production by nadph oxidase 2 regulates muscle glucose uptake during exercise
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a635b493f521447c82852adb296d2252
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Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise

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