Ursane-Type Triterpenes, Phenolics and Phenolic Derivatives from <i>Globimetula braunii</i> Leaf

<i>Globimetula braunii</i> is a hemi-parasitic plant used in African ethnomedicine for the management of microbial infections, rheumatic pain and tumors amongst others. We report the isolation and characterization of eight compounds with their antioxidant and antimicrobial activities. Th...

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Autores principales:	Ayodeji Oluwabunmi Oriola, Adetunji Joseph Aladesanmi, Thomas Oyebode Idowu, Florence O. Akinwumi, Efere Martins Obuotor, Temilolu Idowu, Adebola Omowunmi Oyedeji
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Globimetula braunii</i> Loranthaceae ursane-type triterpenes phenolics antioxidant antimicrobial Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/a63715ea4b5f478f88aaddb5b46576aa
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spelling	oai:doaj.org-article:a63715ea4b5f478f88aaddb5b46576aa2021-11-11T18:31:10ZUrsane-Type Triterpenes, Phenolics and Phenolic Derivatives from <i>Globimetula braunii</i> Leaf10.3390/molecules262165281420-3049https://doaj.org/article/a63715ea4b5f478f88aaddb5b46576aa2021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6528https://doaj.org/toc/1420-3049<i>Globimetula braunii</i> is a hemi-parasitic plant used in African ethnomedicine for the management of microbial infections, rheumatic pain and tumors amongst others. We report the isolation and characterization of eight compounds with their antioxidant and antimicrobial activities. The air-dried powdered leaf was macerated in EtOH/H<sub>2</sub>0 (4:1). The extract was solvent-partitioned into <i>n</i>-hexane, EtOAc, <i>n</i>-BuOH and aqueous fractions. The fractions were screened for their antioxidant properties, using DPPH, FRAP, TAC and FIC assays. Antimicrobial analysis was performed using the micro-broth dilution method. The active EtOAc fraction was purified for its putative compounds on a repeated silica gel column chromatography monitored with TLC-bioautography. The isolated compounds were characterized using spectroscopic methods of UV, FT-IR, NMR and MS. Eight compounds (<b>1</b>–<b>8</b>) were isolated and characterized as 13,27-cycloursane (<b>1</b>), phyllanthone (<b>2</b>), globraunone (<b>3</b>), three phenolics: methyl 3,5-dihydroxy-4-methoxybenzoate (<b>4</b>), methyl 3-methyl-4-hydroxybenzoate (<b>5</b>) and guaiacol (<b>6</b>), as well as two phenol derivatives: 4-formaldehyde phenone (<b>7</b>) and 6-methoxy-<i>2H</i>-inden-5-ol (<b>8</b>). The study identified <b>4</b> and <b>6</b> as natural antioxidant compounds with potential as antimicrobial agents.Ayodeji Oluwabunmi OriolaAdetunji Joseph AladesanmiThomas Oyebode IdowuFlorence O. AkinwumiEfere Martins ObuotorTemilolu IdowuAdebola Omowunmi OyedejiMDPI AGarticle<i>Globimetula braunii</i>Loranthaceaeursane-type triterpenesphenolicsantioxidantantimicrobialOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6528, p 6528 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Globimetula braunii</i> Loranthaceae ursane-type triterpenes phenolics antioxidant antimicrobial Organic chemistry QD241-441
spellingShingle	<i>Globimetula braunii</i> Loranthaceae ursane-type triterpenes phenolics antioxidant antimicrobial Organic chemistry QD241-441 Ayodeji Oluwabunmi Oriola Adetunji Joseph Aladesanmi Thomas Oyebode Idowu Florence O. Akinwumi Efere Martins Obuotor Temilolu Idowu Adebola Omowunmi Oyedeji Ursane-Type Triterpenes, Phenolics and Phenolic Derivatives from <i>Globimetula braunii</i> Leaf
description	<i>Globimetula braunii</i> is a hemi-parasitic plant used in African ethnomedicine for the management of microbial infections, rheumatic pain and tumors amongst others. We report the isolation and characterization of eight compounds with their antioxidant and antimicrobial activities. The air-dried powdered leaf was macerated in EtOH/H<sub>2</sub>0 (4:1). The extract was solvent-partitioned into <i>n</i>-hexane, EtOAc, <i>n</i>-BuOH and aqueous fractions. The fractions were screened for their antioxidant properties, using DPPH, FRAP, TAC and FIC assays. Antimicrobial analysis was performed using the micro-broth dilution method. The active EtOAc fraction was purified for its putative compounds on a repeated silica gel column chromatography monitored with TLC-bioautography. The isolated compounds were characterized using spectroscopic methods of UV, FT-IR, NMR and MS. Eight compounds (<b>1</b>–<b>8</b>) were isolated and characterized as 13,27-cycloursane (<b>1</b>), phyllanthone (<b>2</b>), globraunone (<b>3</b>), three phenolics: methyl 3,5-dihydroxy-4-methoxybenzoate (<b>4</b>), methyl 3-methyl-4-hydroxybenzoate (<b>5</b>) and guaiacol (<b>6</b>), as well as two phenol derivatives: 4-formaldehyde phenone (<b>7</b>) and 6-methoxy-<i>2H</i>-inden-5-ol (<b>8</b>). The study identified <b>4</b> and <b>6</b> as natural antioxidant compounds with potential as antimicrobial agents.
format	article
author	Ayodeji Oluwabunmi Oriola Adetunji Joseph Aladesanmi Thomas Oyebode Idowu Florence O. Akinwumi Efere Martins Obuotor Temilolu Idowu Adebola Omowunmi Oyedeji
author_facet	Ayodeji Oluwabunmi Oriola Adetunji Joseph Aladesanmi Thomas Oyebode Idowu Florence O. Akinwumi Efere Martins Obuotor Temilolu Idowu Adebola Omowunmi Oyedeji
author_sort	Ayodeji Oluwabunmi Oriola
title	Ursane-Type Triterpenes, Phenolics and Phenolic Derivatives from <i>Globimetula braunii</i> Leaf
title_short	Ursane-Type Triterpenes, Phenolics and Phenolic Derivatives from <i>Globimetula braunii</i> Leaf
title_full	Ursane-Type Triterpenes, Phenolics and Phenolic Derivatives from <i>Globimetula braunii</i> Leaf
title_fullStr	Ursane-Type Triterpenes, Phenolics and Phenolic Derivatives from <i>Globimetula braunii</i> Leaf
title_full_unstemmed	Ursane-Type Triterpenes, Phenolics and Phenolic Derivatives from <i>Globimetula braunii</i> Leaf
title_sort	ursane-type triterpenes, phenolics and phenolic derivatives from <i>globimetula braunii</i> leaf
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a63715ea4b5f478f88aaddb5b46576aa
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Ursane-Type Triterpenes, Phenolics and Phenolic Derivatives from <i>Globimetula braunii</i> Leaf

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