Evidence for cognitive impairment in mastocytosis: prevalence, features and correlations to depression.

Mastocytosis is a heterogeneous disease characterized by mast cells accumulation in one or more organs. We have reported that depression is frequent in mastocytosis, but although it was already described, little is known about the prevalence and features of cognitive impairment. Our objective was to...

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Autores principales:	Daniela Silva Moura, Serge Sultan, Sophie Georgin-Lavialle, Stéphane Barete, Olivier Lortholary, Raphael Gaillard, Olivier Hermine
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a637eb482ab849c8a44c7ad4f2439e38
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spelling	oai:doaj.org-article:a637eb482ab849c8a44c7ad4f2439e382021-11-18T07:14:49ZEvidence for cognitive impairment in mastocytosis: prevalence, features and correlations to depression.1932-620310.1371/journal.pone.0039468https://doaj.org/article/a637eb482ab849c8a44c7ad4f2439e382012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22745762/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Mastocytosis is a heterogeneous disease characterized by mast cells accumulation in one or more organs. We have reported that depression is frequent in mastocytosis, but although it was already described, little is known about the prevalence and features of cognitive impairment. Our objective was to describe the prevalence and features of cognitive impairment in a large cohort of patients with this rare disease (n = 57; mean age = 45) and to explore the relations between memory impairment and depression. Objective memory impairment was evaluated using the 3(rd) edition of the Clinical Memory scale of Wechsler. Depression symptoms were evaluated using the Hamilton Depression Rating Scale. Age and education levels were controlled for all patients. Patients with mastocytosis presented high levels of cognitive impairment (memory and/or attention) (n = 22; 38.6%). Cognitive impairment was moderate in 59% of the cases, concerned immediate auditory (41%) and working memory (73%) and was not associated to depression (p≥0.717). In conclusion, immediate auditory memory and attention impairment in mastocytosis are frequent, even in young individuals, and are not consecutive to depression. In mastocytosis, cognitive complaints call for complex neuropsychological assessment. Mild-moderate cognitive impairment and depression constitute two specific but somewhat independent syndromes in mastocytosis. These results suggest differential effects of mast-cell activity in the brain, on systems involved in emotionality and in cognition.Daniela Silva MouraSerge SultanSophie Georgin-LavialleStéphane BareteOlivier LortholaryRaphael GaillardOlivier HerminePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e39468 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniela Silva Moura Serge Sultan Sophie Georgin-Lavialle Stéphane Barete Olivier Lortholary Raphael Gaillard Olivier Hermine Evidence for cognitive impairment in mastocytosis: prevalence, features and correlations to depression.
description	Mastocytosis is a heterogeneous disease characterized by mast cells accumulation in one or more organs. We have reported that depression is frequent in mastocytosis, but although it was already described, little is known about the prevalence and features of cognitive impairment. Our objective was to describe the prevalence and features of cognitive impairment in a large cohort of patients with this rare disease (n = 57; mean age = 45) and to explore the relations between memory impairment and depression. Objective memory impairment was evaluated using the 3(rd) edition of the Clinical Memory scale of Wechsler. Depression symptoms were evaluated using the Hamilton Depression Rating Scale. Age and education levels were controlled for all patients. Patients with mastocytosis presented high levels of cognitive impairment (memory and/or attention) (n = 22; 38.6%). Cognitive impairment was moderate in 59% of the cases, concerned immediate auditory (41%) and working memory (73%) and was not associated to depression (p≥0.717). In conclusion, immediate auditory memory and attention impairment in mastocytosis are frequent, even in young individuals, and are not consecutive to depression. In mastocytosis, cognitive complaints call for complex neuropsychological assessment. Mild-moderate cognitive impairment and depression constitute two specific but somewhat independent syndromes in mastocytosis. These results suggest differential effects of mast-cell activity in the brain, on systems involved in emotionality and in cognition.
format	article
author	Daniela Silva Moura Serge Sultan Sophie Georgin-Lavialle Stéphane Barete Olivier Lortholary Raphael Gaillard Olivier Hermine
author_facet	Daniela Silva Moura Serge Sultan Sophie Georgin-Lavialle Stéphane Barete Olivier Lortholary Raphael Gaillard Olivier Hermine
author_sort	Daniela Silva Moura
title	Evidence for cognitive impairment in mastocytosis: prevalence, features and correlations to depression.
title_short	Evidence for cognitive impairment in mastocytosis: prevalence, features and correlations to depression.
title_full	Evidence for cognitive impairment in mastocytosis: prevalence, features and correlations to depression.
title_fullStr	Evidence for cognitive impairment in mastocytosis: prevalence, features and correlations to depression.
title_full_unstemmed	Evidence for cognitive impairment in mastocytosis: prevalence, features and correlations to depression.
title_sort	evidence for cognitive impairment in mastocytosis: prevalence, features and correlations to depression.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/a637eb482ab849c8a44c7ad4f2439e38
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Evidence for cognitive impairment in mastocytosis: prevalence, features and correlations to depression.

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