Quantifying quality of life and disability of patients with advanced schistosomiasis japonica.

<h4>Background</h4>The Chinese government lists advanced schistosomiasis as a leading healthcare priority due to its serious health and economic impacts, yet it has not been included in the estimates of schistosomiasis burden in the Global Burden of Disease (GBD) study. Therefore, the qu...

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Autores principales:	Tie-Wu Jia, Jürg Utzinger, Yao Deng, Kun Yang, Yi-Yi Li, Jin-Huan Zhu, Charles H King, Xiao-Nong Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/a642f440b49c487f98dd40583f5c01eb
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spelling	oai:doaj.org-article:a642f440b49c487f98dd40583f5c01eb2021-11-18T09:13:33ZQuantifying quality of life and disability of patients with advanced schistosomiasis japonica.1935-27271935-273510.1371/journal.pntd.0000966https://doaj.org/article/a642f440b49c487f98dd40583f5c01eb2011-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21358814/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>The Chinese government lists advanced schistosomiasis as a leading healthcare priority due to its serious health and economic impacts, yet it has not been included in the estimates of schistosomiasis burden in the Global Burden of Disease (GBD) study. Therefore, the quality of life and disability weight (DW) for the advanced cases of schistosomiasis japonica have to be taken into account in the re-estimation of burden of disease due to schistosomiasis.<h4>Methodology/principal findings</h4>A patient-based quality-of-life evaluation was performed for advanced schistosomiasis japonica. Suspected or officially registered advanced cases in a Schistosoma japonicum-hyperendemic county of the People's Republic of China (P.R. China) were screened using a short questionnaire and physical examination. Disability and morbidity were assessed in confirmed cases, using the European quality of life questionnaire with an additional cognitive dimension (known as the "EQ-5D plus"), ultrasonography, and laboratory testing. The age-specific DW of advanced schistosomiasis japonica was estimated based on patients' self-rated health scores on the visual analogue scale of the questionnaire. The relationships between health status, morbidity and DW were explored using multivariate regression models. Of 506 candidates, 215 cases were confirmed as advanced schistosomiasis japonica and evaluated. Most of the patients reported impairments in at least one health dimension, such as pain or discomfort (90.7%), usual activities (87.9%), and anxiety or depression (80.9%). The overall DW was 0.447, and age-specific DWs ranged from 0.378 among individuals aged 30-44 years to 0.510 among the elderly aged ≥ 60 years. DWs are positively associated with loss of work capacity, psychological abnormality, ascites, and active hepatitis B virus, while splenectomy and high albumin were protective factors for quality of life.<h4>Conclusions/significance</h4>These patient-preference disability estimates could provide updated data for a revision of the GBD, as well as for evidence-based decision-making in P.R. China's national schistosomiasis control program.Tie-Wu JiaJürg UtzingerYao DengKun YangYi-Yi LiJin-Huan ZhuCharles H KingXiao-Nong ZhouPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 5, Iss 2, p e966 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Tie-Wu Jia Jürg Utzinger Yao Deng Kun Yang Yi-Yi Li Jin-Huan Zhu Charles H King Xiao-Nong Zhou Quantifying quality of life and disability of patients with advanced schistosomiasis japonica.
description	<h4>Background</h4>The Chinese government lists advanced schistosomiasis as a leading healthcare priority due to its serious health and economic impacts, yet it has not been included in the estimates of schistosomiasis burden in the Global Burden of Disease (GBD) study. Therefore, the quality of life and disability weight (DW) for the advanced cases of schistosomiasis japonica have to be taken into account in the re-estimation of burden of disease due to schistosomiasis.<h4>Methodology/principal findings</h4>A patient-based quality-of-life evaluation was performed for advanced schistosomiasis japonica. Suspected or officially registered advanced cases in a Schistosoma japonicum-hyperendemic county of the People's Republic of China (P.R. China) were screened using a short questionnaire and physical examination. Disability and morbidity were assessed in confirmed cases, using the European quality of life questionnaire with an additional cognitive dimension (known as the "EQ-5D plus"), ultrasonography, and laboratory testing. The age-specific DW of advanced schistosomiasis japonica was estimated based on patients' self-rated health scores on the visual analogue scale of the questionnaire. The relationships between health status, morbidity and DW were explored using multivariate regression models. Of 506 candidates, 215 cases were confirmed as advanced schistosomiasis japonica and evaluated. Most of the patients reported impairments in at least one health dimension, such as pain or discomfort (90.7%), usual activities (87.9%), and anxiety or depression (80.9%). The overall DW was 0.447, and age-specific DWs ranged from 0.378 among individuals aged 30-44 years to 0.510 among the elderly aged ≥ 60 years. DWs are positively associated with loss of work capacity, psychological abnormality, ascites, and active hepatitis B virus, while splenectomy and high albumin were protective factors for quality of life.<h4>Conclusions/significance</h4>These patient-preference disability estimates could provide updated data for a revision of the GBD, as well as for evidence-based decision-making in P.R. China's national schistosomiasis control program.
format	article
author	Tie-Wu Jia Jürg Utzinger Yao Deng Kun Yang Yi-Yi Li Jin-Huan Zhu Charles H King Xiao-Nong Zhou
author_facet	Tie-Wu Jia Jürg Utzinger Yao Deng Kun Yang Yi-Yi Li Jin-Huan Zhu Charles H King Xiao-Nong Zhou
author_sort	Tie-Wu Jia
title	Quantifying quality of life and disability of patients with advanced schistosomiasis japonica.
title_short	Quantifying quality of life and disability of patients with advanced schistosomiasis japonica.
title_full	Quantifying quality of life and disability of patients with advanced schistosomiasis japonica.
title_fullStr	Quantifying quality of life and disability of patients with advanced schistosomiasis japonica.
title_full_unstemmed	Quantifying quality of life and disability of patients with advanced schistosomiasis japonica.
title_sort	quantifying quality of life and disability of patients with advanced schistosomiasis japonica.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/a642f440b49c487f98dd40583f5c01eb
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Quantifying quality of life and disability of patients with advanced schistosomiasis japonica.

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