Functional Recovery & Neurogenesis after Transplantation of Stem Cells from Human Umbilical Cord Blood into Spinal Cord Injured Rats

Background Data: Transplantation of umbilical cord blood stem cells into damaged spinal cords was used experimentally for several years. Such transplants survive and integrate to some degree with the host tissue and may be associated with functional improvement. Purpose: To find out the functional i...

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Autores principales:	Endegena Gemta, Amani El- Baz, Yasser El Wazir, Mohammed Abdo, Hassan Al-Shatoury, Eman Asaada
Formato:	article
Lenguaje:	EN
Publicado:	Egyptian Spine Association 2013
Materias:	stem cells Functional recovery Neurogenesis Spinal cord injury Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a643c6db70dd4dc8bb7fe28a91898d17
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spelling	oai:doaj.org-article:a643c6db70dd4dc8bb7fe28a91898d172021-12-02T03:49:27ZFunctional Recovery & Neurogenesis after Transplantation of Stem Cells from Human Umbilical Cord Blood into Spinal Cord Injured RatsDOI:10.21608/ESJ.2013.38062314-89502314-8969https://doaj.org/article/a643c6db70dd4dc8bb7fe28a91898d172013-01-01T00:00:00Zhttp://esj.journals.ekb.eg/article_3806.htmlhttps://doaj.org/toc/2314-8950https://doaj.org/toc/2314-8969Background Data: Transplantation of umbilical cord blood stem cells into damaged spinal cords was used experimentally for several years. Such transplants survive and integrate to some degree with the host tissue and may be associated with functional improvement. Purpose: To find out the functional improvement, and axon regeneration in spinal cord injured rats after human umbilical cord blood stem cells (HUCBs) transplantation. Study Design: Prospective analytic animal experimental study. Material and Methods: Forty rats were recruited and divided into four groups, each containing 10 rats: Group (1): Control group with no lesion and intervention. Group (2): Injured animals with no treatment Group (3): Injured and injected with saline. Group (4): Injured and injected with HUCBs. Animals were subjected to behavioral assessment using two physiological tests. Histopathological sections and immunohistochemical examination were done. Results: The results of this study have shown that the HUCBs reduced the neurological function deficit to a moderate degree. Conclusion: Remyelination and new astrocyte formation could be established after HUCBs transplantation to the injured rats. (2012ESJ033)Endegena GemtaAmani El- Baz Yasser El Wazir Mohammed Abdo Hassan Al-Shatoury Eman AsaadaEgyptian Spine Associationarticlestem cellsFunctional recoveryNeurogenesisSpinal cord injuryNeurology. Diseases of the nervous systemRC346-429ENEgyptian Spine Journal, Vol 5, Iss 1, Pp 4-13 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	stem cells Functional recovery Neurogenesis Spinal cord injury Neurology. Diseases of the nervous system RC346-429
spellingShingle	stem cells Functional recovery Neurogenesis Spinal cord injury Neurology. Diseases of the nervous system RC346-429 Endegena Gemta Amani El- Baz Yasser El Wazir Mohammed Abdo Hassan Al-Shatoury Eman Asaada Functional Recovery & Neurogenesis after Transplantation of Stem Cells from Human Umbilical Cord Blood into Spinal Cord Injured Rats
description	Background Data: Transplantation of umbilical cord blood stem cells into damaged spinal cords was used experimentally for several years. Such transplants survive and integrate to some degree with the host tissue and may be associated with functional improvement. Purpose: To find out the functional improvement, and axon regeneration in spinal cord injured rats after human umbilical cord blood stem cells (HUCBs) transplantation. Study Design: Prospective analytic animal experimental study. Material and Methods: Forty rats were recruited and divided into four groups, each containing 10 rats: Group (1): Control group with no lesion and intervention. Group (2): Injured animals with no treatment Group (3): Injured and injected with saline. Group (4): Injured and injected with HUCBs. Animals were subjected to behavioral assessment using two physiological tests. Histopathological sections and immunohistochemical examination were done. Results: The results of this study have shown that the HUCBs reduced the neurological function deficit to a moderate degree. Conclusion: Remyelination and new astrocyte formation could be established after HUCBs transplantation to the injured rats. (2012ESJ033)
format	article
author	Endegena Gemta Amani El- Baz Yasser El Wazir Mohammed Abdo Hassan Al-Shatoury Eman Asaada
author_facet	Endegena Gemta Amani El- Baz Yasser El Wazir Mohammed Abdo Hassan Al-Shatoury Eman Asaada
author_sort	Endegena Gemta
title	Functional Recovery & Neurogenesis after Transplantation of Stem Cells from Human Umbilical Cord Blood into Spinal Cord Injured Rats
title_short	Functional Recovery & Neurogenesis after Transplantation of Stem Cells from Human Umbilical Cord Blood into Spinal Cord Injured Rats
title_full	Functional Recovery & Neurogenesis after Transplantation of Stem Cells from Human Umbilical Cord Blood into Spinal Cord Injured Rats
title_fullStr	Functional Recovery & Neurogenesis after Transplantation of Stem Cells from Human Umbilical Cord Blood into Spinal Cord Injured Rats
title_full_unstemmed	Functional Recovery & Neurogenesis after Transplantation of Stem Cells from Human Umbilical Cord Blood into Spinal Cord Injured Rats
title_sort	functional recovery & neurogenesis after transplantation of stem cells from human umbilical cord blood into spinal cord injured rats
publisher	Egyptian Spine Association
publishDate	2013
url	https://doaj.org/article/a643c6db70dd4dc8bb7fe28a91898d17
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Functional Recovery & Neurogenesis after Transplantation of Stem Cells from Human Umbilical Cord Blood into Spinal Cord Injured Rats

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