Disrupting biological sensors of force promotes tissue regeneration in large organisms

Disrupting biological sensors of force promotes tissue regeneration in large organisms

Humans and other large mammals heal wounds by forming fibrotic scar tissue with diminished function. Here, the authors show that disrupting mechanotransduction through the focal adhesion kinase pathway in large animals accelerates healing, prevents fibrosis, and enhances skin regeneration.

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Detalles Bibliográficos
Autores principales: Kellen Chen, Sun Hyung Kwon, Dominic Henn, Britta A. Kuehlmann, Ruth Tevlin, Clark A. Bonham, Michelle Griffin, Artem A. Trotsyuk, Mimi R. Borrelli, Chikage Noishiki, Jagannath Padmanabhan, Janos A. Barrera, Zeshaan N. Maan, Teruyuki Dohi, Chyna J. Mays, Autumn H. Greco, Dharshan Sivaraj, John Q. Lin, Tobias Fehlmann, Alana M. Mermin-Bunnell, Smiti Mittal, Michael S. Hu, Alsu I. Zamaleeva, Andreas Keller, Jayakumar Rajadas, Michael T. Longaker, Michael Januszyk, Geoffrey C. Gurtner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/a6465911a4834ff9b70b7391526b7dc6
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Descripción
Sumario:Humans and other large mammals heal wounds by forming fibrotic scar tissue with diminished function. Here, the authors show that disrupting mechanotransduction through the focal adhesion kinase pathway in large animals accelerates healing, prevents fibrosis, and enhances skin regeneration.

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