Disrupting biological sensors of force promotes tissue regeneration in large organisms
Humans and other large mammals heal wounds by forming fibrotic scar tissue with diminished function. Here, the authors show that disrupting mechanotransduction through the focal adhesion kinase pathway in large animals accelerates healing, prevents fibrosis, and enhances skin regeneration.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/a6465911a4834ff9b70b7391526b7dc6 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:a6465911a4834ff9b70b7391526b7dc6 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:a6465911a4834ff9b70b7391526b7dc62021-12-02T17:19:39ZDisrupting biological sensors of force promotes tissue regeneration in large organisms10.1038/s41467-021-25410-z2041-1723https://doaj.org/article/a6465911a4834ff9b70b7391526b7dc62021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25410-zhttps://doaj.org/toc/2041-1723Humans and other large mammals heal wounds by forming fibrotic scar tissue with diminished function. Here, the authors show that disrupting mechanotransduction through the focal adhesion kinase pathway in large animals accelerates healing, prevents fibrosis, and enhances skin regeneration.Kellen ChenSun Hyung KwonDominic HennBritta A. KuehlmannRuth TevlinClark A. BonhamMichelle GriffinArtem A. TrotsyukMimi R. BorrelliChikage NoishikiJagannath PadmanabhanJanos A. BarreraZeshaan N. MaanTeruyuki DohiChyna J. MaysAutumn H. GrecoDharshan SivarajJohn Q. LinTobias FehlmannAlana M. Mermin-BunnellSmiti MittalMichael S. HuAlsu I. ZamaleevaAndreas KellerJayakumar RajadasMichael T. LongakerMichael JanuszykGeoffrey C. GurtnerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Kellen Chen Sun Hyung Kwon Dominic Henn Britta A. Kuehlmann Ruth Tevlin Clark A. Bonham Michelle Griffin Artem A. Trotsyuk Mimi R. Borrelli Chikage Noishiki Jagannath Padmanabhan Janos A. Barrera Zeshaan N. Maan Teruyuki Dohi Chyna J. Mays Autumn H. Greco Dharshan Sivaraj John Q. Lin Tobias Fehlmann Alana M. Mermin-Bunnell Smiti Mittal Michael S. Hu Alsu I. Zamaleeva Andreas Keller Jayakumar Rajadas Michael T. Longaker Michael Januszyk Geoffrey C. Gurtner Disrupting biological sensors of force promotes tissue regeneration in large organisms |
| description |
Humans and other large mammals heal wounds by forming fibrotic scar tissue with diminished function. Here, the authors show that disrupting mechanotransduction through the focal adhesion kinase pathway in large animals accelerates healing, prevents fibrosis, and enhances skin regeneration. |
| format |
article |
| author |
Kellen Chen Sun Hyung Kwon Dominic Henn Britta A. Kuehlmann Ruth Tevlin Clark A. Bonham Michelle Griffin Artem A. Trotsyuk Mimi R. Borrelli Chikage Noishiki Jagannath Padmanabhan Janos A. Barrera Zeshaan N. Maan Teruyuki Dohi Chyna J. Mays Autumn H. Greco Dharshan Sivaraj John Q. Lin Tobias Fehlmann Alana M. Mermin-Bunnell Smiti Mittal Michael S. Hu Alsu I. Zamaleeva Andreas Keller Jayakumar Rajadas Michael T. Longaker Michael Januszyk Geoffrey C. Gurtner |
| author_facet |
Kellen Chen Sun Hyung Kwon Dominic Henn Britta A. Kuehlmann Ruth Tevlin Clark A. Bonham Michelle Griffin Artem A. Trotsyuk Mimi R. Borrelli Chikage Noishiki Jagannath Padmanabhan Janos A. Barrera Zeshaan N. Maan Teruyuki Dohi Chyna J. Mays Autumn H. Greco Dharshan Sivaraj John Q. Lin Tobias Fehlmann Alana M. Mermin-Bunnell Smiti Mittal Michael S. Hu Alsu I. Zamaleeva Andreas Keller Jayakumar Rajadas Michael T. Longaker Michael Januszyk Geoffrey C. Gurtner |
| author_sort |
Kellen Chen |
| title |
Disrupting biological sensors of force promotes tissue regeneration in large organisms |
| title_short |
Disrupting biological sensors of force promotes tissue regeneration in large organisms |
| title_full |
Disrupting biological sensors of force promotes tissue regeneration in large organisms |
| title_fullStr |
Disrupting biological sensors of force promotes tissue regeneration in large organisms |
| title_full_unstemmed |
Disrupting biological sensors of force promotes tissue regeneration in large organisms |
| title_sort |
disrupting biological sensors of force promotes tissue regeneration in large organisms |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/a6465911a4834ff9b70b7391526b7dc6 |
| work_keys_str_mv |
AT kellenchen disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT sunhyungkwon disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT dominichenn disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT brittaakuehlmann disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT ruthtevlin disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT clarkabonham disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT michellegriffin disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT artematrotsyuk disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT mimirborrelli disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT chikagenoishiki disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT jagannathpadmanabhan disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT janosabarrera disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT zeshaannmaan disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT teruyukidohi disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT chynajmays disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT autumnhgreco disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT dharshansivaraj disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT johnqlin disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT tobiasfehlmann disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT alanammerminbunnell disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT smitimittal disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT michaelshu disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT alsuizamaleeva disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT andreaskeller disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT jayakumarrajadas disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT michaeltlongaker disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT michaeljanuszyk disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms AT geoffreycgurtner disruptingbiologicalsensorsofforcepromotestissueregenerationinlargeorganisms |
| _version_ |
1718381043580403712 |