Automatic inhibitory function in the human somatosensory and motor cortices: An MEG-MRS study

Abstract While the automatic inhibitory function of the human cerebral cortex has been extensively investigated by means of electrophysiological recordings, the corresponding modulating neurochemical mechanisms remain unclear. We aimed to examine whether the primary somatosensory (SI) and primary mo...

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Autores principales:	Chia-Hsiung Cheng, Shang-Yueh Tsai, Chia-Yih Liu, David M. Niddam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a64a73d27baa4cff989ccbf091c78829
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spelling	oai:doaj.org-article:a64a73d27baa4cff989ccbf091c788292021-12-02T11:52:20ZAutomatic inhibitory function in the human somatosensory and motor cortices: An MEG-MRS study10.1038/s41598-017-04564-12045-2322https://doaj.org/article/a64a73d27baa4cff989ccbf091c788292017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04564-1https://doaj.org/toc/2045-2322Abstract While the automatic inhibitory function of the human cerebral cortex has been extensively investigated by means of electrophysiological recordings, the corresponding modulating neurochemical mechanisms remain unclear. We aimed to examine whether the primary somatosensory (SI) and primary motor cortical (MI) inhibitory function is associated with endogenous GABA levels. Eighteen young participants received paired-pulse and single-pulse electrical stimulation to the median nerve during magnetoencephalographic recordings. The SI sensory gating (SG), considered as an automatic inhibitory ability, was measured as the amplitude ratio of Stimulus 2 over Stimulus 1, in the paired-pulse paradigm. In addition, stimulus-induced beta activity, considered to originate from MI and also to be related to inhibitory function, was estimated using the single-pulse paradigm. The GABA+ concentration of the sensorimotor cortex was acquired from each subject by using magnetic resonance spectroscopy (MRS). A lower SG ratio in SI was significantly associated with an increased beta power in MI. More importantly, the beta rebound power, but not SI SG ratio, was positively correlated with GABA+ concentration. Our findings show a tight functional relationship between SI and MI during processing of automatic inhibition. GABA+ levels appear to be more closely related to the automatic inhibitory function of MI than SI.Chia-Hsiung ChengShang-Yueh TsaiChia-Yih LiuDavid M. NiddamNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chia-Hsiung Cheng Shang-Yueh Tsai Chia-Yih Liu David M. Niddam Automatic inhibitory function in the human somatosensory and motor cortices: An MEG-MRS study
description	Abstract While the automatic inhibitory function of the human cerebral cortex has been extensively investigated by means of electrophysiological recordings, the corresponding modulating neurochemical mechanisms remain unclear. We aimed to examine whether the primary somatosensory (SI) and primary motor cortical (MI) inhibitory function is associated with endogenous GABA levels. Eighteen young participants received paired-pulse and single-pulse electrical stimulation to the median nerve during magnetoencephalographic recordings. The SI sensory gating (SG), considered as an automatic inhibitory ability, was measured as the amplitude ratio of Stimulus 2 over Stimulus 1, in the paired-pulse paradigm. In addition, stimulus-induced beta activity, considered to originate from MI and also to be related to inhibitory function, was estimated using the single-pulse paradigm. The GABA+ concentration of the sensorimotor cortex was acquired from each subject by using magnetic resonance spectroscopy (MRS). A lower SG ratio in SI was significantly associated with an increased beta power in MI. More importantly, the beta rebound power, but not SI SG ratio, was positively correlated with GABA+ concentration. Our findings show a tight functional relationship between SI and MI during processing of automatic inhibition. GABA+ levels appear to be more closely related to the automatic inhibitory function of MI than SI.
format	article
author	Chia-Hsiung Cheng Shang-Yueh Tsai Chia-Yih Liu David M. Niddam
author_facet	Chia-Hsiung Cheng Shang-Yueh Tsai Chia-Yih Liu David M. Niddam
author_sort	Chia-Hsiung Cheng
title	Automatic inhibitory function in the human somatosensory and motor cortices: An MEG-MRS study
title_short	Automatic inhibitory function in the human somatosensory and motor cortices: An MEG-MRS study
title_full	Automatic inhibitory function in the human somatosensory and motor cortices: An MEG-MRS study
title_fullStr	Automatic inhibitory function in the human somatosensory and motor cortices: An MEG-MRS study
title_full_unstemmed	Automatic inhibitory function in the human somatosensory and motor cortices: An MEG-MRS study
title_sort	automatic inhibitory function in the human somatosensory and motor cortices: an meg-mrs study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a64a73d27baa4cff989ccbf091c78829
work_keys_str_mv	AT chiahsiungcheng automaticinhibitoryfunctioninthehumansomatosensoryandmotorcorticesanmegmrsstudy AT shangyuehtsai automaticinhibitoryfunctioninthehumansomatosensoryandmotorcorticesanmegmrsstudy AT chiayihliu automaticinhibitoryfunctioninthehumansomatosensoryandmotorcorticesanmegmrsstudy AT davidmniddam automaticinhibitoryfunctioninthehumansomatosensoryandmotorcorticesanmegmrsstudy
_version_	1718395122836570112

Automatic inhibitory function in the human somatosensory and motor cortices: An MEG-MRS study

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