Firstborn microcrystallization method to prepare nanocapsules containing artesunate

Xin-Cai Xiao, Zong-Guo HongSchool of Pharmacy, South-Central University for Nationalities, Wuhan, 430074, ChinaAbstract: We developed a novel method to prepare nanocapsules. A solute often crystallizes when its solubility alters from one solvent to another, and its firstborn crystals are used as tem...

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Autores principales:	Xin-Cai Xiao, Zong-Guo Hong
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a64c62ab67d541c59e768b10d9ee6b79
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spelling	oai:doaj.org-article:a64c62ab67d541c59e768b10d9ee6b792021-12-02T02:10:27ZFirstborn microcrystallization method to prepare nanocapsules containing artesunate1176-91141178-2013https://doaj.org/article/a64c62ab67d541c59e768b10d9ee6b792010-07-01T00:00:00Zhttp://www.dovepress.com/firstborn-microcrystallization-method-to-prepare-nanocapsules-containi-a4799https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Xin-Cai Xiao, Zong-Guo HongSchool of Pharmacy, South-Central University for Nationalities, Wuhan, 430074, ChinaAbstract: We developed a novel method to prepare nanocapsules. A solute often crystallizes when its solubility alters from one solvent to another, and its firstborn crystals are used as templates to prepare nanocapsules for the first time, which is called firstborn microcrystallization method. By using this method, the maximum diameter of the nanocapsules including artesunate is about 76 nm, and wrapping state is well. One important advantage of our method is that the preparation of the nanocapsules operates easily and is a one-time process with no other cumbersome processes necessary, therefore avoiding secondary pollution. The proposed method provides a new route to prepare monodisperse nanocapsules to increase bioavailability of hydrophobic solutes.Keywords: firstborn microcrystallization method, nanocapsules, artesunate Xin-Cai XiaoZong-Guo HongDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 483-486 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Xin-Cai Xiao Zong-Guo Hong Firstborn microcrystallization method to prepare nanocapsules containing artesunate
description	Xin-Cai Xiao, Zong-Guo HongSchool of Pharmacy, South-Central University for Nationalities, Wuhan, 430074, ChinaAbstract: We developed a novel method to prepare nanocapsules. A solute often crystallizes when its solubility alters from one solvent to another, and its firstborn crystals are used as templates to prepare nanocapsules for the first time, which is called firstborn microcrystallization method. By using this method, the maximum diameter of the nanocapsules including artesunate is about 76 nm, and wrapping state is well. One important advantage of our method is that the preparation of the nanocapsules operates easily and is a one-time process with no other cumbersome processes necessary, therefore avoiding secondary pollution. The proposed method provides a new route to prepare monodisperse nanocapsules to increase bioavailability of hydrophobic solutes.Keywords: firstborn microcrystallization method, nanocapsules, artesunate
format	article
author	Xin-Cai Xiao Zong-Guo Hong
author_facet	Xin-Cai Xiao Zong-Guo Hong
author_sort	Xin-Cai Xiao
title	Firstborn microcrystallization method to prepare nanocapsules containing artesunate
title_short	Firstborn microcrystallization method to prepare nanocapsules containing artesunate
title_full	Firstborn microcrystallization method to prepare nanocapsules containing artesunate
title_fullStr	Firstborn microcrystallization method to prepare nanocapsules containing artesunate
title_full_unstemmed	Firstborn microcrystallization method to prepare nanocapsules containing artesunate
title_sort	firstborn microcrystallization method to prepare nanocapsules containing artesunate
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/a64c62ab67d541c59e768b10d9ee6b79
work_keys_str_mv	AT xincaixiao firstbornmicrocrystallizationmethodtopreparenanocapsulescontainingartesunate AT zongguohong firstbornmicrocrystallizationmethodtopreparenanocapsulescontainingartesunate
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Firstborn microcrystallization method to prepare nanocapsules containing artesunate

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