Looking to nature for a new concept in antimicrobial treatments: isoflavonoids from Cytisus striatus as antibiotic adjuvants against MRSA

Abstract The spread of multidrug-resistant Staphylococcus aureus strains, including methicillin-resistant S. aureus (MRSA), has shortened the useful life of anti-staphylococcal drugs enormously. Two approaches can be followed to address this problem: screening various sources for new leads for antib...

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Autores principales:	Ana Cristina Abreu, Aline Coqueiro, Andi R. Sultan, Nicole Lemmens, Hye Kyong Kim, Robert Verpoorte, Willem J. B. van Wamel, Manuel Simões, Young Hae Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a64dcdffdc9d4557959937d11cc6359f
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spelling	oai:doaj.org-article:a64dcdffdc9d4557959937d11cc6359f2021-12-02T12:31:59ZLooking to nature for a new concept in antimicrobial treatments: isoflavonoids from Cytisus striatus as antibiotic adjuvants against MRSA10.1038/s41598-017-03716-72045-2322https://doaj.org/article/a64dcdffdc9d4557959937d11cc6359f2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03716-7https://doaj.org/toc/2045-2322Abstract The spread of multidrug-resistant Staphylococcus aureus strains, including methicillin-resistant S. aureus (MRSA), has shortened the useful life of anti-staphylococcal drugs enormously. Two approaches can be followed to address this problem: screening various sources for new leads for antibiotics or finding ways to disable the resistance mechanisms to existing antibiotics. Plants are resistant to most microorganisms, but despite extensive efforts to identify metabolites that are responsible for this resistance, no substantial progress has been made. Plants possibly use multiple strategies to deal with microorganisms that evolved over time. For this reason, we searched for plants that could potentiate the effects of known antibiotics. From 29 plant species tested, Cytisus striatus clearly showed such an activity and an NMR-based metabolomics study allowed the identification of compounds from the plant extracts that could act as antibiotic adjuvants. Isoflavonoids were found to potentiate the effect of ciprofloxacin and erythromycin against MRSA strains. For the structure-activity relationship (SAR), 22 isoflavonoids were assessed as antibiotic adjuvants. This study reveals a clear synergy between isoflavonoids and the tested antibiotics, showing their great potential for applications in the clinical therapy of infections with antibiotic-resistant microorganisms such as MRSA.Ana Cristina AbreuAline CoqueiroAndi R. SultanNicole LemmensHye Kyong KimRobert VerpoorteWillem J. B. van WamelManuel SimõesYoung Hae ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ana Cristina Abreu Aline Coqueiro Andi R. Sultan Nicole Lemmens Hye Kyong Kim Robert Verpoorte Willem J. B. van Wamel Manuel Simões Young Hae Choi Looking to nature for a new concept in antimicrobial treatments: isoflavonoids from Cytisus striatus as antibiotic adjuvants against MRSA
description	Abstract The spread of multidrug-resistant Staphylococcus aureus strains, including methicillin-resistant S. aureus (MRSA), has shortened the useful life of anti-staphylococcal drugs enormously. Two approaches can be followed to address this problem: screening various sources for new leads for antibiotics or finding ways to disable the resistance mechanisms to existing antibiotics. Plants are resistant to most microorganisms, but despite extensive efforts to identify metabolites that are responsible for this resistance, no substantial progress has been made. Plants possibly use multiple strategies to deal with microorganisms that evolved over time. For this reason, we searched for plants that could potentiate the effects of known antibiotics. From 29 plant species tested, Cytisus striatus clearly showed such an activity and an NMR-based metabolomics study allowed the identification of compounds from the plant extracts that could act as antibiotic adjuvants. Isoflavonoids were found to potentiate the effect of ciprofloxacin and erythromycin against MRSA strains. For the structure-activity relationship (SAR), 22 isoflavonoids were assessed as antibiotic adjuvants. This study reveals a clear synergy between isoflavonoids and the tested antibiotics, showing their great potential for applications in the clinical therapy of infections with antibiotic-resistant microorganisms such as MRSA.
format	article
author	Ana Cristina Abreu Aline Coqueiro Andi R. Sultan Nicole Lemmens Hye Kyong Kim Robert Verpoorte Willem J. B. van Wamel Manuel Simões Young Hae Choi
author_facet	Ana Cristina Abreu Aline Coqueiro Andi R. Sultan Nicole Lemmens Hye Kyong Kim Robert Verpoorte Willem J. B. van Wamel Manuel Simões Young Hae Choi
author_sort	Ana Cristina Abreu
title	Looking to nature for a new concept in antimicrobial treatments: isoflavonoids from Cytisus striatus as antibiotic adjuvants against MRSA
title_short	Looking to nature for a new concept in antimicrobial treatments: isoflavonoids from Cytisus striatus as antibiotic adjuvants against MRSA
title_full	Looking to nature for a new concept in antimicrobial treatments: isoflavonoids from Cytisus striatus as antibiotic adjuvants against MRSA
title_fullStr	Looking to nature for a new concept in antimicrobial treatments: isoflavonoids from Cytisus striatus as antibiotic adjuvants against MRSA
title_full_unstemmed	Looking to nature for a new concept in antimicrobial treatments: isoflavonoids from Cytisus striatus as antibiotic adjuvants against MRSA
title_sort	looking to nature for a new concept in antimicrobial treatments: isoflavonoids from cytisus striatus as antibiotic adjuvants against mrsa
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a64dcdffdc9d4557959937d11cc6359f
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Looking to nature for a new concept in antimicrobial treatments: isoflavonoids from Cytisus striatus as antibiotic adjuvants against MRSA

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