Levels of endothelial substances in patients with newly identified hypertension compared with healthy controls

Introduction. Endothelial dysfunction occurs at the very beginning of hypertension. The primary goal of our study was to determine plasmatic levels of multiple endothelial substances in otherwise healthy patients with primary hypertension and compare them to healthy individuals. Secondary goals were...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Vladislav Biel, Jan Novak, Veronika Rimalova, Marie Tomandlova, Josef Tomandl, Jiri Spac, Miroslav Soucek
Formato:	article
Lenguaje:	EN
Publicado:	Palacký University Olomouc, Faculty of Medicine and Dentistry 2021
Materias:	hypertension nitric oxide plasma endothelial dysfunction Medicine R
Acceso en línea:	https://doaj.org/article/a64e92676bfe4945b1f4ae4104e4919e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a64e92676bfe4945b1f4ae4104e4919e
record_format	dspace
spelling	oai:doaj.org-article:a64e92676bfe4945b1f4ae4104e4919e2021-11-29T09:17:21ZLevels of endothelial substances in patients with newly identified hypertension compared with healthy controls1213-81181804-7521https://doaj.org/article/a64e92676bfe4945b1f4ae4104e4919e2021-11-01T00:00:00Zhttps://biomed.papers.upol.cz/artkey/bio-202104-0008_levels-of-endothelial-substances-in-patients-with-newly-identified-hypertension-compared-with-healthy-controls.phphttps://doaj.org/toc/1213-8118https://doaj.org/toc/1804-7521Introduction. Endothelial dysfunction occurs at the very beginning of hypertension. The primary goal of our study was to determine plasmatic levels of multiple endothelial substances in otherwise healthy patients with primary hypertension and compare them to healthy individuals. Secondary goals were to determine the change in NOx levels after initiation of treatment and to compare the NOx levels in patients with established resistant hypertension. Materials and Methods. 87 consecutive patients were enrolled. In the exploratory cohort of 22 healthy and 28 hypertensive individuals, plasmatic levels of big endotelin-1, asymmetric dimethylarginin, osteopontin, oxidized LDL, 3-nitro-L-tyrosine, growth/differentiation factor 15, intercellular adhesion molecule, vascular cell adhesion molecule, tumor necrosis factor-α, vascular endothelial growth factor, interleukins -1β, -6 and nitric oxide levels (NO, expressed as NOx) were determined. The remaining 27 individuals were used as a validation cohort. Ten patients with established resistant hypertension were enrolled from our Hypertension Clinic. Results. There was a statistically significant difference in NOx levels between healthy controls and hypertensive patients/resistant hypertensive patients: 45.164 µmol/L ± 48.627 vs 17.763 µmol/L ± 10.333 (P=0.00004)/14.36 µmol/L ± 7.194 (P=0.00007). Conclusion. We identified a decrease in total NOx plasmatic levels in otherwise healthy patients with primary hypertension that was more profound in patients with resistant hypertension. Plasmatic levels of other determined endothelial substances did not differ among the groups. However, due to the significant variability of plasmatic NOx levels even in healthy controls and many factors that affect it, we cannot recommend it to be used to assess endothelial function routinely.Vladislav BielJan NovakVeronika RimalovaMarie TomandlovaJosef TomandlJiri SpacMiroslav SoucekPalacký University Olomouc, Faculty of Medicine and Dentistryarticlehypertensionnitric oxideplasmaendothelial dysfunctionMedicineRENBiomedical Papers, Vol 165, Iss 4, Pp 395-401 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypertension nitric oxide plasma endothelial dysfunction Medicine R
spellingShingle	hypertension nitric oxide plasma endothelial dysfunction Medicine R Vladislav Biel Jan Novak Veronika Rimalova Marie Tomandlova Josef Tomandl Jiri Spac Miroslav Soucek Levels of endothelial substances in patients with newly identified hypertension compared with healthy controls
description	Introduction. Endothelial dysfunction occurs at the very beginning of hypertension. The primary goal of our study was to determine plasmatic levels of multiple endothelial substances in otherwise healthy patients with primary hypertension and compare them to healthy individuals. Secondary goals were to determine the change in NOx levels after initiation of treatment and to compare the NOx levels in patients with established resistant hypertension. Materials and Methods. 87 consecutive patients were enrolled. In the exploratory cohort of 22 healthy and 28 hypertensive individuals, plasmatic levels of big endotelin-1, asymmetric dimethylarginin, osteopontin, oxidized LDL, 3-nitro-L-tyrosine, growth/differentiation factor 15, intercellular adhesion molecule, vascular cell adhesion molecule, tumor necrosis factor-α, vascular endothelial growth factor, interleukins -1β, -6 and nitric oxide levels (NO, expressed as NOx) were determined. The remaining 27 individuals were used as a validation cohort. Ten patients with established resistant hypertension were enrolled from our Hypertension Clinic. Results. There was a statistically significant difference in NOx levels between healthy controls and hypertensive patients/resistant hypertensive patients: 45.164 µmol/L ± 48.627 vs 17.763 µmol/L ± 10.333 (P=0.00004)/14.36 µmol/L ± 7.194 (P=0.00007). Conclusion. We identified a decrease in total NOx plasmatic levels in otherwise healthy patients with primary hypertension that was more profound in patients with resistant hypertension. Plasmatic levels of other determined endothelial substances did not differ among the groups. However, due to the significant variability of plasmatic NOx levels even in healthy controls and many factors that affect it, we cannot recommend it to be used to assess endothelial function routinely.
format	article
author	Vladislav Biel Jan Novak Veronika Rimalova Marie Tomandlova Josef Tomandl Jiri Spac Miroslav Soucek
author_facet	Vladislav Biel Jan Novak Veronika Rimalova Marie Tomandlova Josef Tomandl Jiri Spac Miroslav Soucek
author_sort	Vladislav Biel
title	Levels of endothelial substances in patients with newly identified hypertension compared with healthy controls
title_short	Levels of endothelial substances in patients with newly identified hypertension compared with healthy controls
title_full	Levels of endothelial substances in patients with newly identified hypertension compared with healthy controls
title_fullStr	Levels of endothelial substances in patients with newly identified hypertension compared with healthy controls
title_full_unstemmed	Levels of endothelial substances in patients with newly identified hypertension compared with healthy controls
title_sort	levels of endothelial substances in patients with newly identified hypertension compared with healthy controls
publisher	Palacký University Olomouc, Faculty of Medicine and Dentistry
publishDate	2021
url	https://doaj.org/article/a64e92676bfe4945b1f4ae4104e4919e
work_keys_str_mv	AT vladislavbiel levelsofendothelialsubstancesinpatientswithnewlyidentifiedhypertensioncomparedwithhealthycontrols AT jannovak levelsofendothelialsubstancesinpatientswithnewlyidentifiedhypertensioncomparedwithhealthycontrols AT veronikarimalova levelsofendothelialsubstancesinpatientswithnewlyidentifiedhypertensioncomparedwithhealthycontrols AT marietomandlova levelsofendothelialsubstancesinpatientswithnewlyidentifiedhypertensioncomparedwithhealthycontrols AT joseftomandl levelsofendothelialsubstancesinpatientswithnewlyidentifiedhypertensioncomparedwithhealthycontrols AT jirispac levelsofendothelialsubstancesinpatientswithnewlyidentifiedhypertensioncomparedwithhealthycontrols AT miroslavsoucek levelsofendothelialsubstancesinpatientswithnewlyidentifiedhypertensioncomparedwithhealthycontrols
_version_	1718407419538702336

Levels of endothelial substances in patients with newly identified hypertension compared with healthy controls

Ejemplares similares