Network biology discovers pathogen contact points in host protein-protein interactomes

Nodes with high centrality in protein–protein interaction (PPI) networks are known to be essential in some organisms. Here, the authors in contrast find that in the interactome of A. thaliana central nodes are enriched in conditional and immune phenotypes and are preferred targets of pathogens.

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Autores principales:	Hadia Ahmed, T. C. Howton, Yali Sun, Natascha Weinberger, Youssef Belkhadir, M. Shahid Mukhtar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a64fd292ad4442d9ad1237cf1879b916
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id	oai:doaj.org-article:a64fd292ad4442d9ad1237cf1879b916
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spelling	oai:doaj.org-article:a64fd292ad4442d9ad1237cf1879b9162021-12-02T15:34:48ZNetwork biology discovers pathogen contact points in host protein-protein interactomes10.1038/s41467-018-04632-82041-1723https://doaj.org/article/a64fd292ad4442d9ad1237cf1879b9162018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04632-8https://doaj.org/toc/2041-1723Nodes with high centrality in protein–protein interaction (PPI) networks are known to be essential in some organisms. Here, the authors in contrast find that in the interactome of A. thaliana central nodes are enriched in conditional and immune phenotypes and are preferred targets of pathogens.Hadia AhmedT. C. HowtonYali SunNatascha WeinbergerYoussef BelkhadirM. Shahid MukhtarNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hadia Ahmed T. C. Howton Yali Sun Natascha Weinberger Youssef Belkhadir M. Shahid Mukhtar Network biology discovers pathogen contact points in host protein-protein interactomes
description	Nodes with high centrality in protein–protein interaction (PPI) networks are known to be essential in some organisms. Here, the authors in contrast find that in the interactome of A. thaliana central nodes are enriched in conditional and immune phenotypes and are preferred targets of pathogens.
format	article
author	Hadia Ahmed T. C. Howton Yali Sun Natascha Weinberger Youssef Belkhadir M. Shahid Mukhtar
author_facet	Hadia Ahmed T. C. Howton Yali Sun Natascha Weinberger Youssef Belkhadir M. Shahid Mukhtar
author_sort	Hadia Ahmed
title	Network biology discovers pathogen contact points in host protein-protein interactomes
title_short	Network biology discovers pathogen contact points in host protein-protein interactomes
title_full	Network biology discovers pathogen contact points in host protein-protein interactomes
title_fullStr	Network biology discovers pathogen contact points in host protein-protein interactomes
title_full_unstemmed	Network biology discovers pathogen contact points in host protein-protein interactomes
title_sort	network biology discovers pathogen contact points in host protein-protein interactomes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a64fd292ad4442d9ad1237cf1879b916
work_keys_str_mv	AT hadiaahmed networkbiologydiscoverspathogencontactpointsinhostproteinproteininteractomes AT tchowton networkbiologydiscoverspathogencontactpointsinhostproteinproteininteractomes AT yalisun networkbiologydiscoverspathogencontactpointsinhostproteinproteininteractomes AT nataschaweinberger networkbiologydiscoverspathogencontactpointsinhostproteinproteininteractomes AT youssefbelkhadir networkbiologydiscoverspathogencontactpointsinhostproteinproteininteractomes AT mshahidmukhtar networkbiologydiscoverspathogencontactpointsinhostproteinproteininteractomes
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Network biology discovers pathogen contact points in host protein-protein interactomes

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