Gamma irradiation-mediated inactivation of enveloped viruses with conservation of genome integrity: Potential application for SARS-CoV-2 inactivated vaccine development

Radiation inactivation of enveloped viruses occurs as the result of damages at the molecular level of their genome. The rapidly emerging and ongoing coronavirus disease 2019 (COVID-19) pneumonia pandemic prompted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a global health...

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Autores principales:	Abolaban Fouad A., Djouider Fathi M.
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	sars-cov-2 virus virus genome virus infectivity gamma irradiation virus inactivation vaccine development Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a6500c9670054b9bbb3a0f08bce132b4
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spelling	oai:doaj.org-article:a6500c9670054b9bbb3a0f08bce132b42021-12-05T14:10:41ZGamma irradiation-mediated inactivation of enveloped viruses with conservation of genome integrity: Potential application for SARS-CoV-2 inactivated vaccine development2391-541210.1515/biol-2021-0051https://doaj.org/article/a6500c9670054b9bbb3a0f08bce132b42021-06-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0051https://doaj.org/toc/2391-5412Radiation inactivation of enveloped viruses occurs as the result of damages at the molecular level of their genome. The rapidly emerging and ongoing coronavirus disease 2019 (COVID-19) pneumonia pandemic prompted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a global health crisis and an economic devastation. The readiness of an active and safe vaccine against the COVID-19 has become a race against time in this unqualified global panic caused by this pandemic. In this review, which we hope will be helpful in the current situation of COVID-19, we analyze the potential use of γ-irradiation to inactivate this virus by damaging at the molecular level its genetic material. This inactivation is a vital step towards the design and development of an urgently needed, effective vaccine against this disease.Abolaban Fouad A.Djouider Fathi M.De Gruyterarticlesars-cov-2 virusvirus genomevirus infectivitygamma irradiationvirus inactivationvaccine developmentBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 558-570 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sars-cov-2 virus virus genome virus infectivity gamma irradiation virus inactivation vaccine development Biology (General) QH301-705.5
spellingShingle	sars-cov-2 virus virus genome virus infectivity gamma irradiation virus inactivation vaccine development Biology (General) QH301-705.5 Abolaban Fouad A. Djouider Fathi M. Gamma irradiation-mediated inactivation of enveloped viruses with conservation of genome integrity: Potential application for SARS-CoV-2 inactivated vaccine development
description	Radiation inactivation of enveloped viruses occurs as the result of damages at the molecular level of their genome. The rapidly emerging and ongoing coronavirus disease 2019 (COVID-19) pneumonia pandemic prompted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a global health crisis and an economic devastation. The readiness of an active and safe vaccine against the COVID-19 has become a race against time in this unqualified global panic caused by this pandemic. In this review, which we hope will be helpful in the current situation of COVID-19, we analyze the potential use of γ-irradiation to inactivate this virus by damaging at the molecular level its genetic material. This inactivation is a vital step towards the design and development of an urgently needed, effective vaccine against this disease.
format	article
author	Abolaban Fouad A. Djouider Fathi M.
author_facet	Abolaban Fouad A. Djouider Fathi M.
author_sort	Abolaban Fouad A.
title	Gamma irradiation-mediated inactivation of enveloped viruses with conservation of genome integrity: Potential application for SARS-CoV-2 inactivated vaccine development
title_short	Gamma irradiation-mediated inactivation of enveloped viruses with conservation of genome integrity: Potential application for SARS-CoV-2 inactivated vaccine development
title_full	Gamma irradiation-mediated inactivation of enveloped viruses with conservation of genome integrity: Potential application for SARS-CoV-2 inactivated vaccine development
title_fullStr	Gamma irradiation-mediated inactivation of enveloped viruses with conservation of genome integrity: Potential application for SARS-CoV-2 inactivated vaccine development
title_full_unstemmed	Gamma irradiation-mediated inactivation of enveloped viruses with conservation of genome integrity: Potential application for SARS-CoV-2 inactivated vaccine development
title_sort	gamma irradiation-mediated inactivation of enveloped viruses with conservation of genome integrity: potential application for sars-cov-2 inactivated vaccine development
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/a6500c9670054b9bbb3a0f08bce132b4
work_keys_str_mv	AT abolabanfouada gammairradiationmediatedinactivationofenvelopedviruseswithconservationofgenomeintegritypotentialapplicationforsarscov2inactivatedvaccinedevelopment AT djouiderfathim gammairradiationmediatedinactivationofenvelopedviruseswithconservationofgenomeintegritypotentialapplicationforsarscov2inactivatedvaccinedevelopment
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Gamma irradiation-mediated inactivation of enveloped viruses with conservation of genome integrity: Potential application for SARS-CoV-2 inactivated vaccine development

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