Detection of measles cases in the Republic of Guinea in 2017–2018

In 2017, WHO reported 596 confirmed measles cases in Guinea Republic connected to the 2016–2017 epidemic outbreak that was stopped after additional immunization (SIA) against measles in two provinces of the country. Improving the effectiveness of SIA is associated with the identification of epidemio...

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Autores principales:	I. N. Lavrentieva, M. A. Bichurina, A. Y. Antipova, J. Camara, N.F. Magassouba
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2020
Materias:	measles measles elimination program africa vaccination revaccination Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/a6500d9a3f2e4bcb97aea319f43eb21b
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spelling	oai:doaj.org-article:a6500d9a3f2e4bcb97aea319f43eb21b2021-11-22T07:09:53ZDetection of measles cases in the Republic of Guinea in 2017–20182220-76192313-739810.15789/2220-7619-DOM-1333https://doaj.org/article/a6500d9a3f2e4bcb97aea319f43eb21b2020-08-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/1333https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398In 2017, WHO reported 596 confirmed measles cases in Guinea Republic connected to the 2016–2017 epidemic outbreak that was stopped after additional immunization (SIA) against measles in two provinces of the country. Improving the effectiveness of SIA is associated with the identification of epidemiologically significant groups of the population. The aim of the study was to analyze 2017–2018 measles cases and assess population immunity to measles virus in the Republic of Guinea. Materials and methods. A total of 810 blood serum samples collected from patients with maculo-papular rash and clinical diagnosis “measles?” were tested for measles virus-specific IgM-and IgG antibody level. 445 sera of conditionally healthy individuals aged 7 months to 67 years were examined for anti-measles virus IgG antibody level. Immunoglobulins of classes M and G were detected by ELISA with test systems «Anti-Measles Virus ELISA (IgM)» (Euro immun, Germany) and «Anti-Measles Virus ELISA (IgG)» (Euroimmun, Germany). Results and discussion.In 2017–2018, the epidemic process of the measles in the Republic of Guinea proceeded very intensively, being markedly prevalent in children among age groups. In 2018, more than half of the cases (61.6%) were identified in children aged 1 to 5 years old; the second most abundant age group was children under one year (18.6%), probably due to violated measles vaccination, which in GR are subject to children of nine months of age. It was found that 16.4% of patients (60 out of 366) had documented data on measles vaccination. Potentially, high proportion of measles cases among pre-vaccinated subjects was due to insufficient immune response to a single immunization in children of 9 months of age. Moreover, lowered vaccine-related properties might also be violated “cold chain” during vaccine transportation occurring in tropical climate. Analyzing 445 subjects revealed that total number of measles virus seronegative subjects was 8.3%. However, the vast majority of them were children and young adults aged 7 months to 22 years, where 52.4% of seronegative subjects were identified. Thus, the data obtained indicate that intensive measles virus circulation in human population was continued that necessitate interventions for improving epidemiological surveillance, extend routine measles vaccination coverage and conduct SIAs against measles in GR.I. N. LavrentievaM. A. BichurinaA. Y. AntipovaJ. CamaraN.F. MagassoubaSankt-Peterburg : NIIÈM imeni Pasteraarticlemeaslesmeasles elimination programafricavaccinationrevaccinationInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 10, Iss 3, Pp 570-574 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	measles measles elimination program africa vaccination revaccination Infectious and parasitic diseases RC109-216
spellingShingle	measles measles elimination program africa vaccination revaccination Infectious and parasitic diseases RC109-216 I. N. Lavrentieva M. A. Bichurina A. Y. Antipova J. Camara N.F. Magassouba Detection of measles cases in the Republic of Guinea in 2017–2018
description	In 2017, WHO reported 596 confirmed measles cases in Guinea Republic connected to the 2016–2017 epidemic outbreak that was stopped after additional immunization (SIA) against measles in two provinces of the country. Improving the effectiveness of SIA is associated with the identification of epidemiologically significant groups of the population. The aim of the study was to analyze 2017–2018 measles cases and assess population immunity to measles virus in the Republic of Guinea. Materials and methods. A total of 810 blood serum samples collected from patients with maculo-papular rash and clinical diagnosis “measles?” were tested for measles virus-specific IgM-and IgG antibody level. 445 sera of conditionally healthy individuals aged 7 months to 67 years were examined for anti-measles virus IgG antibody level. Immunoglobulins of classes M and G were detected by ELISA with test systems «Anti-Measles Virus ELISA (IgM)» (Euro immun, Germany) and «Anti-Measles Virus ELISA (IgG)» (Euroimmun, Germany). Results and discussion.In 2017–2018, the epidemic process of the measles in the Republic of Guinea proceeded very intensively, being markedly prevalent in children among age groups. In 2018, more than half of the cases (61.6%) were identified in children aged 1 to 5 years old; the second most abundant age group was children under one year (18.6%), probably due to violated measles vaccination, which in GR are subject to children of nine months of age. It was found that 16.4% of patients (60 out of 366) had documented data on measles vaccination. Potentially, high proportion of measles cases among pre-vaccinated subjects was due to insufficient immune response to a single immunization in children of 9 months of age. Moreover, lowered vaccine-related properties might also be violated “cold chain” during vaccine transportation occurring in tropical climate. Analyzing 445 subjects revealed that total number of measles virus seronegative subjects was 8.3%. However, the vast majority of them were children and young adults aged 7 months to 22 years, where 52.4% of seronegative subjects were identified. Thus, the data obtained indicate that intensive measles virus circulation in human population was continued that necessitate interventions for improving epidemiological surveillance, extend routine measles vaccination coverage and conduct SIAs against measles in GR.
format	article
author	I. N. Lavrentieva M. A. Bichurina A. Y. Antipova J. Camara N.F. Magassouba
author_facet	I. N. Lavrentieva M. A. Bichurina A. Y. Antipova J. Camara N.F. Magassouba
author_sort	I. N. Lavrentieva
title	Detection of measles cases in the Republic of Guinea in 2017–2018
title_short	Detection of measles cases in the Republic of Guinea in 2017–2018
title_full	Detection of measles cases in the Republic of Guinea in 2017–2018
title_fullStr	Detection of measles cases in the Republic of Guinea in 2017–2018
title_full_unstemmed	Detection of measles cases in the Republic of Guinea in 2017–2018
title_sort	detection of measles cases in the republic of guinea in 2017–2018
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2020
url	https://doaj.org/article/a6500d9a3f2e4bcb97aea319f43eb21b
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Detection of measles cases in the Republic of Guinea in 2017–2018

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