Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis

Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis

VEGF-A/VEGFR2 signaling is a key driver of endothelial cell migration during sprouting angiogenesis. Here Genet et al. show that endophilin A2 regulates these processes by mediating clathrin-independent VEGFR2 internalization.

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Autores principales: Gael Genet, Kevin Boyé, Thomas Mathivet, Roxana Ola, Feng Zhang, Alexandre Dubrac, Jinyu Li, Nafiisha Genet, Luiz Henrique Geraldo, Lorena Benedetti, Steffen Künzel, Laurence Pibouin-Fragner, Jean-Leon Thomas, Anne Eichmann
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/a65242a5aee94d9999a57269b93f9bd4
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spelling oai:doaj.org-article:a65242a5aee94d9999a57269b93f9bd42021-12-02T16:58:06ZEndophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis10.1038/s41467-019-10359-x2041-1723https://doaj.org/article/a65242a5aee94d9999a57269b93f9bd42019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10359-xhttps://doaj.org/toc/2041-1723VEGF-A/VEGFR2 signaling is a key driver of endothelial cell migration during sprouting angiogenesis. Here Genet et al. show that endophilin A2 regulates these processes by mediating clathrin-independent VEGFR2 internalization.Gael GenetKevin BoyéThomas MathivetRoxana OlaFeng ZhangAlexandre DubracJinyu LiNafiisha GenetLuiz Henrique GeraldoLorena BenedettiSteffen KünzelLaurence Pibouin-FragnerJean-Leon ThomasAnne EichmannNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Gael Genet
Kevin Boyé
Thomas Mathivet
Roxana Ola
Feng Zhang
Alexandre Dubrac
Jinyu Li
Nafiisha Genet
Luiz Henrique Geraldo
Lorena Benedetti
Steffen Künzel
Laurence Pibouin-Fragner
Jean-Leon Thomas
Anne Eichmann
Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis
description VEGF-A/VEGFR2 signaling is a key driver of endothelial cell migration during sprouting angiogenesis. Here Genet et al. show that endophilin A2 regulates these processes by mediating clathrin-independent VEGFR2 internalization.
format article
author Gael Genet
Kevin Boyé
Thomas Mathivet
Roxana Ola
Feng Zhang
Alexandre Dubrac
Jinyu Li
Nafiisha Genet
Luiz Henrique Geraldo
Lorena Benedetti
Steffen Künzel
Laurence Pibouin-Fragner
Jean-Leon Thomas
Anne Eichmann
author_facet Gael Genet
Kevin Boyé
Thomas Mathivet
Roxana Ola
Feng Zhang
Alexandre Dubrac
Jinyu Li
Nafiisha Genet
Luiz Henrique Geraldo
Lorena Benedetti
Steffen Künzel
Laurence Pibouin-Fragner
Jean-Leon Thomas
Anne Eichmann
author_sort Gael Genet
title Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis
title_short Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis
title_full Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis
title_fullStr Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis
title_full_unstemmed Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis
title_sort endophilin-a2 dependent vegfr2 endocytosis promotes sprouting angiogenesis
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/a65242a5aee94d9999a57269b93f9bd4
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