Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography.

<h4>Aims</h4>Insulin resistance associates with development of metabolic syndrome and risk of cardiovascular disease. The link between insulin resistance and cardiovascular disease is complex and multifactorial. Confirming the genetic link between insulin resistance, type 2 diabetes, and...

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Autores principales:	Regitze Skals, Maria Lukács Krogager, Emil Vincent R Appel, Theresia M Schnurr, Christian Theil Have, Gunnar Gislason, Henrik Enghusen Poulsen, Lars Køber, Thomas Engstrøm, Steen Stender, Torben Hansen, Niels Grarup, Christina Ji-Young Lee, Charlotte Andersson, Christian Torp-Pedersen, Peter E Weeke
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a6529a0471d94c2bacf90eead93e4511
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spelling	oai:doaj.org-article:a6529a0471d94c2bacf90eead93e45112021-12-02T20:07:06ZInsulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography.1932-620310.1371/journal.pone.0252855https://doaj.org/article/a6529a0471d94c2bacf90eead93e45112021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252855https://doaj.org/toc/1932-6203<h4>Aims</h4>Insulin resistance associates with development of metabolic syndrome and risk of cardiovascular disease. The link between insulin resistance and cardiovascular disease is complex and multifactorial. Confirming the genetic link between insulin resistance, type 2 diabetes, and coronary artery disease, as well as the extent of coronary artery disease, is important and may provide better risk stratification for patients at risk. We investigated whether a genetic risk score of 53 single nucleotide polymorphisms known to be associated with insulin resistance phenotypes was associated with diabetes and burden of coronary artery disease.<h4>Methods and results</h4>We genotyped patients with a coronary angiography performed in the capital region of Denmark from 2010-2014 and constructed a genetic risk score of the 53 single nucleotide polymorphisms. Logistic regression using quartiles of the genetic risk score was performed to determine associations with diabetes and coronary artery disease. Associations with the extent of coronary artery disease, defined as one-, two- or three-vessel coronary artery disease, was determined by multinomial logistic regression. We identified 4,963 patients, of which 17% had diabetes and 55% had significant coronary artery disease. Of the latter, 27%, 14% and 14% had one, two or three-vessel coronary artery disease, respectively. No significant increased risk of diabetes was identified comparing the highest genetic risk score quartile with the lowest. An increased risk of coronary artery disease was found for patients with the highest genetic risk score quartile in both unadjusted and adjusted analyses, OR 1.21 (95% CI: 1.03, 1.42, p = 0.02) and 1.25 (95% CI 1.06, 1.48, p<0.01), respectively. In the adjusted multinomial logistic regression, patients in the highest genetic risk score quartile were more likely to develop three-vessel coronary artery disease compared with patients in the lowest genetic risk score quartile, OR 1.41 (95% CI: 1.10, 1.82, p<0.01).<h4>Conclusions</h4>Among patients referred for coronary angiography, only a strong genetic predisposition to insulin resistance was associated with risk of coronary artery disease and with a greater disease burden.Regitze SkalsMaria Lukács KrogagerEmil Vincent R AppelTheresia M SchnurrChristian Theil HaveGunnar GislasonHenrik Enghusen PoulsenLars KøberThomas EngstrømSteen StenderTorben HansenNiels GrarupChristina Ji-Young LeeCharlotte AnderssonChristian Torp-PedersenPeter E WeekePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252855 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Regitze Skals Maria Lukács Krogager Emil Vincent R Appel Theresia M Schnurr Christian Theil Have Gunnar Gislason Henrik Enghusen Poulsen Lars Køber Thomas Engstrøm Steen Stender Torben Hansen Niels Grarup Christina Ji-Young Lee Charlotte Andersson Christian Torp-Pedersen Peter E Weeke Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography.
description	<h4>Aims</h4>Insulin resistance associates with development of metabolic syndrome and risk of cardiovascular disease. The link between insulin resistance and cardiovascular disease is complex and multifactorial. Confirming the genetic link between insulin resistance, type 2 diabetes, and coronary artery disease, as well as the extent of coronary artery disease, is important and may provide better risk stratification for patients at risk. We investigated whether a genetic risk score of 53 single nucleotide polymorphisms known to be associated with insulin resistance phenotypes was associated with diabetes and burden of coronary artery disease.<h4>Methods and results</h4>We genotyped patients with a coronary angiography performed in the capital region of Denmark from 2010-2014 and constructed a genetic risk score of the 53 single nucleotide polymorphisms. Logistic regression using quartiles of the genetic risk score was performed to determine associations with diabetes and coronary artery disease. Associations with the extent of coronary artery disease, defined as one-, two- or three-vessel coronary artery disease, was determined by multinomial logistic regression. We identified 4,963 patients, of which 17% had diabetes and 55% had significant coronary artery disease. Of the latter, 27%, 14% and 14% had one, two or three-vessel coronary artery disease, respectively. No significant increased risk of diabetes was identified comparing the highest genetic risk score quartile with the lowest. An increased risk of coronary artery disease was found for patients with the highest genetic risk score quartile in both unadjusted and adjusted analyses, OR 1.21 (95% CI: 1.03, 1.42, p = 0.02) and 1.25 (95% CI 1.06, 1.48, p<0.01), respectively. In the adjusted multinomial logistic regression, patients in the highest genetic risk score quartile were more likely to develop three-vessel coronary artery disease compared with patients in the lowest genetic risk score quartile, OR 1.41 (95% CI: 1.10, 1.82, p<0.01).<h4>Conclusions</h4>Among patients referred for coronary angiography, only a strong genetic predisposition to insulin resistance was associated with risk of coronary artery disease and with a greater disease burden.
format	article
author	Regitze Skals Maria Lukács Krogager Emil Vincent R Appel Theresia M Schnurr Christian Theil Have Gunnar Gislason Henrik Enghusen Poulsen Lars Køber Thomas Engstrøm Steen Stender Torben Hansen Niels Grarup Christina Ji-Young Lee Charlotte Andersson Christian Torp-Pedersen Peter E Weeke
author_facet	Regitze Skals Maria Lukács Krogager Emil Vincent R Appel Theresia M Schnurr Christian Theil Have Gunnar Gislason Henrik Enghusen Poulsen Lars Køber Thomas Engstrøm Steen Stender Torben Hansen Niels Grarup Christina Ji-Young Lee Charlotte Andersson Christian Torp-Pedersen Peter E Weeke
author_sort	Regitze Skals
title	Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography.
title_short	Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography.
title_full	Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography.
title_fullStr	Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography.
title_full_unstemmed	Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography.
title_sort	insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/a6529a0471d94c2bacf90eead93e4511
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Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography.

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