Inhibition of VEGF-C modulates distal lymphatic remodeling and secondary metastasis.

Tumor-associated lymphatics are postulated to provide a transit route for disseminating metastatic cells. This notion is supported by preclinical findings that inhibition of pro-lymphangiogenic signaling during tumor development reduces cell spread to sentinel lymph nodes (SLNs). However, it is uncl...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alvin Gogineni, Maresa Caunt, Ailey Crow, Chingwei V Lee, Germaine Fuh, Nicholas van Bruggen, Weilan Ye, Robby M Weimer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a652bd60748b455490ab8d1771e992ac
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a652bd60748b455490ab8d1771e992ac
record_format	dspace
spelling	oai:doaj.org-article:a652bd60748b455490ab8d1771e992ac2021-11-18T07:37:31ZInhibition of VEGF-C modulates distal lymphatic remodeling and secondary metastasis.1932-620310.1371/journal.pone.0068755https://doaj.org/article/a652bd60748b455490ab8d1771e992ac2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23874750/?tool=EBIhttps://doaj.org/toc/1932-6203Tumor-associated lymphatics are postulated to provide a transit route for disseminating metastatic cells. This notion is supported by preclinical findings that inhibition of pro-lymphangiogenic signaling during tumor development reduces cell spread to sentinel lymph nodes (SLNs). However, it is unclear how lymphatics downstream of SLNs contribute to metastatic spread into distal organs, or if modulating distal lymph transport impacts disease progression. Utilizing murine models of metastasis, longitudinal in vivo imaging of lymph transport, and function blocking antibodies against two VEGF family members, we provide evidence that distal lymphatics undergo disease course-dependent up-regulation of lymph transport coincidental with structural remodeling. Inhibition of VEGF-C activity with antibodies against VEGF-C or NRP2 prevented these disease-associated changes. Furthermore, utilizing a novel model of adjuvant treatment, we demonstrate that antagonism of VEGF-C or NRP2 decreases post SLN metastasis. These data support a potential therapeutic strategy for inhibiting distant metastatic dissemination via targeting tumor-associated lymphatic remodeling.Alvin GogineniMaresa CauntAiley CrowChingwei V LeeGermaine FuhNicholas van BruggenWeilan YeRobby M WeimerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e68755 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alvin Gogineni Maresa Caunt Ailey Crow Chingwei V Lee Germaine Fuh Nicholas van Bruggen Weilan Ye Robby M Weimer Inhibition of VEGF-C modulates distal lymphatic remodeling and secondary metastasis.
description	Tumor-associated lymphatics are postulated to provide a transit route for disseminating metastatic cells. This notion is supported by preclinical findings that inhibition of pro-lymphangiogenic signaling during tumor development reduces cell spread to sentinel lymph nodes (SLNs). However, it is unclear how lymphatics downstream of SLNs contribute to metastatic spread into distal organs, or if modulating distal lymph transport impacts disease progression. Utilizing murine models of metastasis, longitudinal in vivo imaging of lymph transport, and function blocking antibodies against two VEGF family members, we provide evidence that distal lymphatics undergo disease course-dependent up-regulation of lymph transport coincidental with structural remodeling. Inhibition of VEGF-C activity with antibodies against VEGF-C or NRP2 prevented these disease-associated changes. Furthermore, utilizing a novel model of adjuvant treatment, we demonstrate that antagonism of VEGF-C or NRP2 decreases post SLN metastasis. These data support a potential therapeutic strategy for inhibiting distant metastatic dissemination via targeting tumor-associated lymphatic remodeling.
format	article
author	Alvin Gogineni Maresa Caunt Ailey Crow Chingwei V Lee Germaine Fuh Nicholas van Bruggen Weilan Ye Robby M Weimer
author_facet	Alvin Gogineni Maresa Caunt Ailey Crow Chingwei V Lee Germaine Fuh Nicholas van Bruggen Weilan Ye Robby M Weimer
author_sort	Alvin Gogineni
title	Inhibition of VEGF-C modulates distal lymphatic remodeling and secondary metastasis.
title_short	Inhibition of VEGF-C modulates distal lymphatic remodeling and secondary metastasis.
title_full	Inhibition of VEGF-C modulates distal lymphatic remodeling and secondary metastasis.
title_fullStr	Inhibition of VEGF-C modulates distal lymphatic remodeling and secondary metastasis.
title_full_unstemmed	Inhibition of VEGF-C modulates distal lymphatic remodeling and secondary metastasis.
title_sort	inhibition of vegf-c modulates distal lymphatic remodeling and secondary metastasis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/a652bd60748b455490ab8d1771e992ac
work_keys_str_mv	AT alvingogineni inhibitionofvegfcmodulatesdistallymphaticremodelingandsecondarymetastasis AT maresacaunt inhibitionofvegfcmodulatesdistallymphaticremodelingandsecondarymetastasis AT aileycrow inhibitionofvegfcmodulatesdistallymphaticremodelingandsecondarymetastasis AT chingweivlee inhibitionofvegfcmodulatesdistallymphaticremodelingandsecondarymetastasis AT germainefuh inhibitionofvegfcmodulatesdistallymphaticremodelingandsecondarymetastasis AT nicholasvanbruggen inhibitionofvegfcmodulatesdistallymphaticremodelingandsecondarymetastasis AT weilanye inhibitionofvegfcmodulatesdistallymphaticremodelingandsecondarymetastasis AT robbymweimer inhibitionofvegfcmodulatesdistallymphaticremodelingandsecondarymetastasis
_version_	1718423181243449344

Inhibition of VEGF-C modulates distal lymphatic remodeling and secondary metastasis.

Ejemplares similares