Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways

In the central nervous system, the maturation of glial cells is temporally and functionally coupled with that of the vascular network during postnatal development. Here the authors show that oligodendroglial HIFα regulates CNS angiogenesis through Wnt-independent and VEGF-dependent signaling, while...

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Auteurs principaux:	Sheng Zhang, Bokyung Kim, Xiaoqing Zhu, Xuehong Gui, Yan Wang, Zhaohui Lan, Preeti Prabhu, Kenneth Fond, Aijun Wang, Fuzheng Guo
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/a65b57afc4f8481493c09c67dabde278
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id	oai:doaj.org-article:a65b57afc4f8481493c09c67dabde278
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spelling	oai:doaj.org-article:a65b57afc4f8481493c09c67dabde2782021-12-02T15:39:19ZGlial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways10.1038/s41467-020-15656-42041-1723https://doaj.org/article/a65b57afc4f8481493c09c67dabde2782020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15656-4https://doaj.org/toc/2041-1723In the central nervous system, the maturation of glial cells is temporally and functionally coupled with that of the vascular network during postnatal development. Here the authors show that oligodendroglial HIFα regulates CNS angiogenesis through Wnt-independent and VEGF-dependent signaling, while astroglial HIFα participates through Wnt-dependent signaling.Sheng ZhangBokyung KimXiaoqing ZhuXuehong GuiYan WangZhaohui LanPreeti PrabhuKenneth FondAijun WangFuzheng GuoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sheng Zhang Bokyung Kim Xiaoqing Zhu Xuehong Gui Yan Wang Zhaohui Lan Preeti Prabhu Kenneth Fond Aijun Wang Fuzheng Guo Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways
description	In the central nervous system, the maturation of glial cells is temporally and functionally coupled with that of the vascular network during postnatal development. Here the authors show that oligodendroglial HIFα regulates CNS angiogenesis through Wnt-independent and VEGF-dependent signaling, while astroglial HIFα participates through Wnt-dependent signaling.
format	article
author	Sheng Zhang Bokyung Kim Xiaoqing Zhu Xuehong Gui Yan Wang Zhaohui Lan Preeti Prabhu Kenneth Fond Aijun Wang Fuzheng Guo
author_facet	Sheng Zhang Bokyung Kim Xiaoqing Zhu Xuehong Gui Yan Wang Zhaohui Lan Preeti Prabhu Kenneth Fond Aijun Wang Fuzheng Guo
author_sort	Sheng Zhang
title	Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways
title_short	Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways
title_full	Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways
title_fullStr	Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways
title_full_unstemmed	Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways
title_sort	glial type specific regulation of cns angiogenesis by hifα-activated different signaling pathways
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a65b57afc4f8481493c09c67dabde278
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_version_	1718385950916083712

Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways

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