Novel bioactive glass based injectable bone cement with improved osteoinductivity and its in vivo evaluation

Abstract Recently, more and more attention has been paid to the development of a new generation of injectable bone cements that are bioactive, biodegradable and are able to have appropriate mechanical properties for treatment of vertebral compression fractures (VCFs). In this study, a novel PSC/CS c...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tengjiao zhu, Huihui Ren, Ailing Li, Bingchuan Liu, Caiyun cui, Yanmei Dong, Yun Tian, Dong Qiu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a6621605c8cb4982aef581557bb544cd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a6621605c8cb4982aef581557bb544cd
record_format	dspace
spelling	oai:doaj.org-article:a6621605c8cb4982aef581557bb544cd2021-12-02T11:53:00ZNovel bioactive glass based injectable bone cement with improved osteoinductivity and its in vivo evaluation10.1038/s41598-017-03207-92045-2322https://doaj.org/article/a6621605c8cb4982aef581557bb544cd2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03207-9https://doaj.org/toc/2045-2322Abstract Recently, more and more attention has been paid to the development of a new generation of injectable bone cements that are bioactive, biodegradable and are able to have appropriate mechanical properties for treatment of vertebral compression fractures (VCFs). In this study, a novel PSC/CS composite cement with high content of PSC (a phytic acid-derived bioactive glass) was prepared and evaluated in both vitro and vivo. The PSC/CS cement showed excellent injectability, good resistance to disintegration, radiopacity and suitable mechanical properties. The in vitro test showed that the cement was bioactive, biocompatible and could maintain its shape sustainably, which made it possible to provide a long-term mechanical support for bone regeneration. Radiography, microcomputed tomography and histology of critical sized rabbit femoral condyle defects implanted with the cements proved the resorption and osteoinductivity of the cement. Compared with the PMMA and CSPC, there were more osteocyte and trabeculae at the Bone-Cement interface in the group PSC/CS cement. The volume of the residual bone cement suggested that PSC/CS had certain ability of degradation and the resorption rate was much lower than that of the CSPC cement. Together, the results indicated that the cement was a promising bone cement to treat the VCFs.Tengjiao zhuHuihui RenAiling LiBingchuan LiuCaiyun cuiYanmei DongYun TianDong QiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tengjiao zhu Huihui Ren Ailing Li Bingchuan Liu Caiyun cui Yanmei Dong Yun Tian Dong Qiu Novel bioactive glass based injectable bone cement with improved osteoinductivity and its in vivo evaluation
description	Abstract Recently, more and more attention has been paid to the development of a new generation of injectable bone cements that are bioactive, biodegradable and are able to have appropriate mechanical properties for treatment of vertebral compression fractures (VCFs). In this study, a novel PSC/CS composite cement with high content of PSC (a phytic acid-derived bioactive glass) was prepared and evaluated in both vitro and vivo. The PSC/CS cement showed excellent injectability, good resistance to disintegration, radiopacity and suitable mechanical properties. The in vitro test showed that the cement was bioactive, biocompatible and could maintain its shape sustainably, which made it possible to provide a long-term mechanical support for bone regeneration. Radiography, microcomputed tomography and histology of critical sized rabbit femoral condyle defects implanted with the cements proved the resorption and osteoinductivity of the cement. Compared with the PMMA and CSPC, there were more osteocyte and trabeculae at the Bone-Cement interface in the group PSC/CS cement. The volume of the residual bone cement suggested that PSC/CS had certain ability of degradation and the resorption rate was much lower than that of the CSPC cement. Together, the results indicated that the cement was a promising bone cement to treat the VCFs.
format	article
author	Tengjiao zhu Huihui Ren Ailing Li Bingchuan Liu Caiyun cui Yanmei Dong Yun Tian Dong Qiu
author_facet	Tengjiao zhu Huihui Ren Ailing Li Bingchuan Liu Caiyun cui Yanmei Dong Yun Tian Dong Qiu
author_sort	Tengjiao zhu
title	Novel bioactive glass based injectable bone cement with improved osteoinductivity and its in vivo evaluation
title_short	Novel bioactive glass based injectable bone cement with improved osteoinductivity and its in vivo evaluation
title_full	Novel bioactive glass based injectable bone cement with improved osteoinductivity and its in vivo evaluation
title_fullStr	Novel bioactive glass based injectable bone cement with improved osteoinductivity and its in vivo evaluation
title_full_unstemmed	Novel bioactive glass based injectable bone cement with improved osteoinductivity and its in vivo evaluation
title_sort	novel bioactive glass based injectable bone cement with improved osteoinductivity and its in vivo evaluation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a6621605c8cb4982aef581557bb544cd
work_keys_str_mv	AT tengjiaozhu novelbioactiveglassbasedinjectablebonecementwithimprovedosteoinductivityanditsinvivoevaluation AT huihuiren novelbioactiveglassbasedinjectablebonecementwithimprovedosteoinductivityanditsinvivoevaluation AT ailingli novelbioactiveglassbasedinjectablebonecementwithimprovedosteoinductivityanditsinvivoevaluation AT bingchuanliu novelbioactiveglassbasedinjectablebonecementwithimprovedosteoinductivityanditsinvivoevaluation AT caiyuncui novelbioactiveglassbasedinjectablebonecementwithimprovedosteoinductivityanditsinvivoevaluation AT yanmeidong novelbioactiveglassbasedinjectablebonecementwithimprovedosteoinductivityanditsinvivoevaluation AT yuntian novelbioactiveglassbasedinjectablebonecementwithimprovedosteoinductivityanditsinvivoevaluation AT dongqiu novelbioactiveglassbasedinjectablebonecementwithimprovedosteoinductivityanditsinvivoevaluation
_version_	1718394944349011968

Novel bioactive glass based injectable bone cement with improved osteoinductivity and its in vivo evaluation

Ejemplares similares