Dissecting myosin-5B mechanosensitivity and calcium regulation at the single molecule level

Myosin-5B is an actin-based motor important for endosome recycling, but the molecular mechanism underlying its motility remains unknown. Here authors use single molecule imaging and high-speed laser tweezers to dissect the mechanoenzymatic properties of myosin-5B, which shows processive motility wit...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lucia Gardini, Sarah M. Heissler, Claudia Arbore, Yi Yang, James R. Sellers, Francesco S. Pavone, Marco Capitanio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a663d8e49b69440c972ca488748037c2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a663d8e49b69440c972ca488748037c2
record_format	dspace
spelling	oai:doaj.org-article:a663d8e49b69440c972ca488748037c22021-12-02T17:33:19ZDissecting myosin-5B mechanosensitivity and calcium regulation at the single molecule level10.1038/s41467-018-05251-z2041-1723https://doaj.org/article/a663d8e49b69440c972ca488748037c22018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05251-zhttps://doaj.org/toc/2041-1723Myosin-5B is an actin-based motor important for endosome recycling, but the molecular mechanism underlying its motility remains unknown. Here authors use single molecule imaging and high-speed laser tweezers to dissect the mechanoenzymatic properties of myosin-5B, which shows processive motility with peculiar mechanosensitivity.Lucia GardiniSarah M. HeisslerClaudia ArboreYi YangJames R. SellersFrancesco S. PavoneMarco CapitanioNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lucia Gardini Sarah M. Heissler Claudia Arbore Yi Yang James R. Sellers Francesco S. Pavone Marco Capitanio Dissecting myosin-5B mechanosensitivity and calcium regulation at the single molecule level
description	Myosin-5B is an actin-based motor important for endosome recycling, but the molecular mechanism underlying its motility remains unknown. Here authors use single molecule imaging and high-speed laser tweezers to dissect the mechanoenzymatic properties of myosin-5B, which shows processive motility with peculiar mechanosensitivity.
format	article
author	Lucia Gardini Sarah M. Heissler Claudia Arbore Yi Yang James R. Sellers Francesco S. Pavone Marco Capitanio
author_facet	Lucia Gardini Sarah M. Heissler Claudia Arbore Yi Yang James R. Sellers Francesco S. Pavone Marco Capitanio
author_sort	Lucia Gardini
title	Dissecting myosin-5B mechanosensitivity and calcium regulation at the single molecule level
title_short	Dissecting myosin-5B mechanosensitivity and calcium regulation at the single molecule level
title_full	Dissecting myosin-5B mechanosensitivity and calcium regulation at the single molecule level
title_fullStr	Dissecting myosin-5B mechanosensitivity and calcium regulation at the single molecule level
title_full_unstemmed	Dissecting myosin-5B mechanosensitivity and calcium regulation at the single molecule level
title_sort	dissecting myosin-5b mechanosensitivity and calcium regulation at the single molecule level
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a663d8e49b69440c972ca488748037c2
work_keys_str_mv	AT luciagardini dissectingmyosin5bmechanosensitivityandcalciumregulationatthesinglemoleculelevel AT sarahmheissler dissectingmyosin5bmechanosensitivityandcalciumregulationatthesinglemoleculelevel AT claudiaarbore dissectingmyosin5bmechanosensitivityandcalciumregulationatthesinglemoleculelevel AT yiyang dissectingmyosin5bmechanosensitivityandcalciumregulationatthesinglemoleculelevel AT jamesrsellers dissectingmyosin5bmechanosensitivityandcalciumregulationatthesinglemoleculelevel AT francescospavone dissectingmyosin5bmechanosensitivityandcalciumregulationatthesinglemoleculelevel AT marcocapitanio dissectingmyosin5bmechanosensitivityandcalciumregulationatthesinglemoleculelevel
_version_	1718380017563467776

Dissecting myosin-5B mechanosensitivity and calcium regulation at the single molecule level

Ejemplares similares