Predictive value of pre-arrest albumin level with GO-FAR score in patients with in-hospital cardiac arrest

Abstract We investigated whether combining the pre-arrest serum albumin level could improve the performance of the Good Outcome Following Attempted Resuscitation (GO-FAR) score for predicting neurologic outcomes in in-hospital cardiac arrest patients. Adult patients who were admitted to a tertiary c...

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Autores principales:	Seok-In Hong, Youn-Jung Kim, Yeon Joo Cho, Jin Won Huh, Sang-Bum Hong, Won Young Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a66510fa8465455587e3ffbbcbff409b
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spelling	oai:doaj.org-article:a66510fa8465455587e3ffbbcbff409b2021-12-02T14:59:09ZPredictive value of pre-arrest albumin level with GO-FAR score in patients with in-hospital cardiac arrest10.1038/s41598-021-90203-92045-2322https://doaj.org/article/a66510fa8465455587e3ffbbcbff409b2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90203-9https://doaj.org/toc/2045-2322Abstract We investigated whether combining the pre-arrest serum albumin level could improve the performance of the Good Outcome Following Attempted Resuscitation (GO-FAR) score for predicting neurologic outcomes in in-hospital cardiac arrest patients. Adult patients who were admitted to a tertiary care hospital between 2013 and 2017 were assessed. Their pre-arrest serum albumin levels were measured within 24 h before the cardiac arrest. According to albumin levels, the patients were divided into quartiles and were assigned 1, 0, 0, and, − 2 points. Patients were allocated to the derivation (n = 419) and validation (n = 444) cohorts. The proportion of favorable outcome increased in a stepwise manner across increasing quartiles (p for trend < 0.018). Area under receiver operating characteristic curve (AUROC) of the albumin-added model was significantly higher than that of the original GO-FAR model (0.848 vs. 0.839; p = 0.033). The results were consistent in the validation cohort (AUROC 0.799 vs. 0.791; p = 0.034). Net reclassification indices of the albumin-added model were 0.059 (95% confidence interval [CI] − 0.037 to 0.094) and 0.072 (95% CI 0.013–0.132) in the derivation and validation cohorts, respectively. An improvement in predictive performance was found by adding the ordinal scale of pre-arrest albumin levels to the original GO-FAR score.Seok-In HongYoun-Jung KimYeon Joo ChoJin Won HuhSang-Bum HongWon Young KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seok-In Hong Youn-Jung Kim Yeon Joo Cho Jin Won Huh Sang-Bum Hong Won Young Kim Predictive value of pre-arrest albumin level with GO-FAR score in patients with in-hospital cardiac arrest
description	Abstract We investigated whether combining the pre-arrest serum albumin level could improve the performance of the Good Outcome Following Attempted Resuscitation (GO-FAR) score for predicting neurologic outcomes in in-hospital cardiac arrest patients. Adult patients who were admitted to a tertiary care hospital between 2013 and 2017 were assessed. Their pre-arrest serum albumin levels were measured within 24 h before the cardiac arrest. According to albumin levels, the patients were divided into quartiles and were assigned 1, 0, 0, and, − 2 points. Patients were allocated to the derivation (n = 419) and validation (n = 444) cohorts. The proportion of favorable outcome increased in a stepwise manner across increasing quartiles (p for trend < 0.018). Area under receiver operating characteristic curve (AUROC) of the albumin-added model was significantly higher than that of the original GO-FAR model (0.848 vs. 0.839; p = 0.033). The results were consistent in the validation cohort (AUROC 0.799 vs. 0.791; p = 0.034). Net reclassification indices of the albumin-added model were 0.059 (95% confidence interval [CI] − 0.037 to 0.094) and 0.072 (95% CI 0.013–0.132) in the derivation and validation cohorts, respectively. An improvement in predictive performance was found by adding the ordinal scale of pre-arrest albumin levels to the original GO-FAR score.
format	article
author	Seok-In Hong Youn-Jung Kim Yeon Joo Cho Jin Won Huh Sang-Bum Hong Won Young Kim
author_facet	Seok-In Hong Youn-Jung Kim Yeon Joo Cho Jin Won Huh Sang-Bum Hong Won Young Kim
author_sort	Seok-In Hong
title	Predictive value of pre-arrest albumin level with GO-FAR score in patients with in-hospital cardiac arrest
title_short	Predictive value of pre-arrest albumin level with GO-FAR score in patients with in-hospital cardiac arrest
title_full	Predictive value of pre-arrest albumin level with GO-FAR score in patients with in-hospital cardiac arrest
title_fullStr	Predictive value of pre-arrest albumin level with GO-FAR score in patients with in-hospital cardiac arrest
title_full_unstemmed	Predictive value of pre-arrest albumin level with GO-FAR score in patients with in-hospital cardiac arrest
title_sort	predictive value of pre-arrest albumin level with go-far score in patients with in-hospital cardiac arrest
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a66510fa8465455587e3ffbbcbff409b
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Predictive value of pre-arrest albumin level with GO-FAR score in patients with in-hospital cardiac arrest

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