Pharmacological properties of selenium and its preparations: from antioxidant to neuroprotector

Selenium is an essential component of more than two dozen enzymes and other selenoproteins that play critical roles in reproduction, DNA synthesis, thyroid hormone metabolism, and protection from oxidative damage and infection. Selenium has a protective action against some forms of cancer and ca...

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Autores principales:	Igor F. Belenichev, Nadia O. Gorchakov, Iryna B. Samura, Natalia V. Savchenko, Nina V. Bukhtiyarova, Olena O. Popazova
Formato:	article
Lenguaje:	EN
Publicado:	Pensoft Publishers 2021
Materias:	Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/a665ead55503422eb86e699a439fa0a8
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spelling	oai:doaj.org-article:a665ead55503422eb86e699a439fa0a82021-12-05T04:30:52ZPharmacological properties of selenium and its preparations: from antioxidant to neuroprotector10.3897/rrpharmacology.7.730512658-381Xhttps://doaj.org/article/a665ead55503422eb86e699a439fa0a82021-12-01T00:00:00Zhttps://rrpharmacology.pensoft.net/article/73051/download/pdf/https://rrpharmacology.pensoft.net/article/73051/download/xml/https://rrpharmacology.pensoft.net/article/73051/https://doaj.org/toc/2658-381XSelenium is an essential component of more than two dozen enzymes and other selenoproteins that play critical roles in reproduction, DNA synthesis, thyroid hormone metabolism, and protection from oxidative damage and infection. Selenium has a protective action against some forms of cancer and cardiovascular diseases, modulates levels of inflammatory mediators, promotes to maintain bone homeostasis and protects against bone loss. Selenium significance as a cardioprotective agent may be associated not only with its antioxidant properties, but also with its ability to prevent inflammation, autophagy, as well as the intrinsic and extrinsic apoptosis pathways. Signaling pathways, such as p-AMPK, PARP, Nrf2, STAT, are involved in the protective effects of selenium. Selenium protects against cardiovascular damage by increasing the survival rate of cardiomyocytes, including a mitochondria-dependent pathway and autophagy through peroxisome proliferator-activated receptors. Research demonstrating neuroprotective and cardioprotective effects of selenium preparations – selenoline, selenocysteine and selenomethionine – is growing at a rapid rate. It has been established that these compounds are able to normalize the levels of heat shock proteins (HSP70), which limit the cytotoxic effects of free radicals, produce energotropic action, prevent a decrease in the membrane mitochondria charge, and the opening of the mitochondrial pore. Also regulate the expression of transmembrane factors NF-kB, c-fos, which is associated with their main biological function of chaperone proteins, providing protection of neurons from damage. In this review, we want to emphasize pharmacological role of Selenium and its derivatives on human health is very complex and has yet to be fully understood.Igor F. BelenichevNadia O. GorchakovIryna B. SamuraNatalia V. SavchenkoNina V. BukhtiyarovaOlena O. PopazovaPensoft PublishersarticleTherapeutics. PharmacologyRM1-950ENResearch Results in Pharmacology, Vol 7, Iss 4, Pp 29-40 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutics. Pharmacology RM1-950
spellingShingle	Therapeutics. Pharmacology RM1-950 Igor F. Belenichev Nadia O. Gorchakov Iryna B. Samura Natalia V. Savchenko Nina V. Bukhtiyarova Olena O. Popazova Pharmacological properties of selenium and its preparations: from antioxidant to neuroprotector
description	Selenium is an essential component of more than two dozen enzymes and other selenoproteins that play critical roles in reproduction, DNA synthesis, thyroid hormone metabolism, and protection from oxidative damage and infection. Selenium has a protective action against some forms of cancer and cardiovascular diseases, modulates levels of inflammatory mediators, promotes to maintain bone homeostasis and protects against bone loss. Selenium significance as a cardioprotective agent may be associated not only with its antioxidant properties, but also with its ability to prevent inflammation, autophagy, as well as the intrinsic and extrinsic apoptosis pathways. Signaling pathways, such as p-AMPK, PARP, Nrf2, STAT, are involved in the protective effects of selenium. Selenium protects against cardiovascular damage by increasing the survival rate of cardiomyocytes, including a mitochondria-dependent pathway and autophagy through peroxisome proliferator-activated receptors. Research demonstrating neuroprotective and cardioprotective effects of selenium preparations – selenoline, selenocysteine and selenomethionine – is growing at a rapid rate. It has been established that these compounds are able to normalize the levels of heat shock proteins (HSP70), which limit the cytotoxic effects of free radicals, produce energotropic action, prevent a decrease in the membrane mitochondria charge, and the opening of the mitochondrial pore. Also regulate the expression of transmembrane factors NF-kB, c-fos, which is associated with their main biological function of chaperone proteins, providing protection of neurons from damage. In this review, we want to emphasize pharmacological role of Selenium and its derivatives on human health is very complex and has yet to be fully understood.
format	article
author	Igor F. Belenichev Nadia O. Gorchakov Iryna B. Samura Natalia V. Savchenko Nina V. Bukhtiyarova Olena O. Popazova
author_facet	Igor F. Belenichev Nadia O. Gorchakov Iryna B. Samura Natalia V. Savchenko Nina V. Bukhtiyarova Olena O. Popazova
author_sort	Igor F. Belenichev
title	Pharmacological properties of selenium and its preparations: from antioxidant to neuroprotector
title_short	Pharmacological properties of selenium and its preparations: from antioxidant to neuroprotector
title_full	Pharmacological properties of selenium and its preparations: from antioxidant to neuroprotector
title_fullStr	Pharmacological properties of selenium and its preparations: from antioxidant to neuroprotector
title_full_unstemmed	Pharmacological properties of selenium and its preparations: from antioxidant to neuroprotector
title_sort	pharmacological properties of selenium and its preparations: from antioxidant to neuroprotector
publisher	Pensoft Publishers
publishDate	2021
url	https://doaj.org/article/a665ead55503422eb86e699a439fa0a8
work_keys_str_mv	AT igorfbelenichev pharmacologicalpropertiesofseleniumanditspreparationsfromantioxidanttoneuroprotector AT nadiaogorchakov pharmacologicalpropertiesofseleniumanditspreparationsfromantioxidanttoneuroprotector AT irynabsamura pharmacologicalpropertiesofseleniumanditspreparationsfromantioxidanttoneuroprotector AT nataliavsavchenko pharmacologicalpropertiesofseleniumanditspreparationsfromantioxidanttoneuroprotector AT ninavbukhtiyarova pharmacologicalpropertiesofseleniumanditspreparationsfromantioxidanttoneuroprotector AT olenaopopazova pharmacologicalpropertiesofseleniumanditspreparationsfromantioxidanttoneuroprotector
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﻿Pharmacological properties of selenium and its preparations: from antioxidant to neuroprotector

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Pharmacological properties of selenium and its preparations: from antioxidant to neuroprotector