EVALUATION OF PROGNOSTIC FACTORS IN PATIENTS WITH RELAPSED HODGKIN’S LYMPHOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANT

Objective: To identify the prognostic factors in relapsed Hodgkin’s Lymphoma patients with regards to their impact on the outcome of autologous hematopoietic stem cell transplant. Study Design: Retrospective observational study. Place and Duration of Study: Department of Medical Oncology, Shau...

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Autores principales:	Jhanzeb Iftikhar, Hafiz Abubakar Sarwar, Fareeha Sheikh, Mohammad Iqbal Shah, Shafqual Ali Khan, Muhammad Abu Bakar, Neelam Siddiqui
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	autologous stem cell transplant hodgkin’s lymphoma Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a6666984a311421ea81f23ba7079fa44
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spelling	oai:doaj.org-article:a6666984a311421ea81f23ba7079fa442021-11-24T03:08:06ZEVALUATION OF PROGNOSTIC FACTORS IN PATIENTS WITH RELAPSED HODGKIN’S LYMPHOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANT0030-96482411-8842https://doaj.org/article/a6666984a311421ea81f23ba7079fa442021-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/4132/3632https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To identify the prognostic factors in relapsed Hodgkin’s Lymphoma patients with regards to their impact on the outcome of autologous hematopoietic stem cell transplant. Study Design: Retrospective observational study. Place and Duration of Study: Department of Medical Oncology, Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore, Jun 1999 to Jun 2019. Methodology: Out of a total of 2061 Hodgkin’s Lymphoma patients, 37 (1.8%) patients with relapsed disease underwent autotransplant and were studied using the Hospital Information System. We obtained details of clinicopathological factors, treatment, and outcome. In our study, the outcome variable was event after transplant (relapse/disease progression/death). Results: Among the 37 relapsed Hodgkin’s Lymphoma patients undergoing auto-transplant, 24 (64.9%) patients had an early relapse after first-line chemotherapy. In this early relapse group of 24 patients, 9 (37.5%) remained well after auto-transplant but 15 (62.5%) patients had an event. Out of 37 relapsed Hodgkin’s Lymphoma patients undergoing auto-transplant, a complete response on pre-transplant imaging was observed in 24 (64.9%) patients. In those 24 patients with a complete response on pre-transplant imaging, 16 (66.7%) patients remained well after transplant while 8 (33.3%) patients had a worse event. Twoyear progression-free and overall survival proportions were 56% and 77% respectively. Conclusion: Complete metabolic response on pre-transplant imaging was associated with better overall survival. Adverse factors observed were initial short duration of complete response, bulky disease at relapse, variables comprising international prognostic score, B symptoms, and raised erythrocyte sedimentation rate at relapse.Jhanzeb IftikharHafiz Abubakar SarwarFareeha SheikhMohammad Iqbal ShahShafqual Ali KhanMuhammad Abu BakarNeelam SiddiquiArmy Medical College Rawalpindiarticleautologous stem cell transplanthodgkin’s lymphomaMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 5, Pp 1833-1838 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autologous stem cell transplant hodgkin’s lymphoma Medicine R Medicine (General) R5-920
spellingShingle	autologous stem cell transplant hodgkin’s lymphoma Medicine R Medicine (General) R5-920 Jhanzeb Iftikhar Hafiz Abubakar Sarwar Fareeha Sheikh Mohammad Iqbal Shah Shafqual Ali Khan Muhammad Abu Bakar Neelam Siddiqui EVALUATION OF PROGNOSTIC FACTORS IN PATIENTS WITH RELAPSED HODGKIN’S LYMPHOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANT
description	Objective: To identify the prognostic factors in relapsed Hodgkin’s Lymphoma patients with regards to their impact on the outcome of autologous hematopoietic stem cell transplant. Study Design: Retrospective observational study. Place and Duration of Study: Department of Medical Oncology, Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore, Jun 1999 to Jun 2019. Methodology: Out of a total of 2061 Hodgkin’s Lymphoma patients, 37 (1.8%) patients with relapsed disease underwent autotransplant and were studied using the Hospital Information System. We obtained details of clinicopathological factors, treatment, and outcome. In our study, the outcome variable was event after transplant (relapse/disease progression/death). Results: Among the 37 relapsed Hodgkin’s Lymphoma patients undergoing auto-transplant, 24 (64.9%) patients had an early relapse after first-line chemotherapy. In this early relapse group of 24 patients, 9 (37.5%) remained well after auto-transplant but 15 (62.5%) patients had an event. Out of 37 relapsed Hodgkin’s Lymphoma patients undergoing auto-transplant, a complete response on pre-transplant imaging was observed in 24 (64.9%) patients. In those 24 patients with a complete response on pre-transplant imaging, 16 (66.7%) patients remained well after transplant while 8 (33.3%) patients had a worse event. Twoyear progression-free and overall survival proportions were 56% and 77% respectively. Conclusion: Complete metabolic response on pre-transplant imaging was associated with better overall survival. Adverse factors observed were initial short duration of complete response, bulky disease at relapse, variables comprising international prognostic score, B symptoms, and raised erythrocyte sedimentation rate at relapse.
format	article
author	Jhanzeb Iftikhar Hafiz Abubakar Sarwar Fareeha Sheikh Mohammad Iqbal Shah Shafqual Ali Khan Muhammad Abu Bakar Neelam Siddiqui
author_facet	Jhanzeb Iftikhar Hafiz Abubakar Sarwar Fareeha Sheikh Mohammad Iqbal Shah Shafqual Ali Khan Muhammad Abu Bakar Neelam Siddiqui
author_sort	Jhanzeb Iftikhar
title	EVALUATION OF PROGNOSTIC FACTORS IN PATIENTS WITH RELAPSED HODGKIN’S LYMPHOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANT
title_short	EVALUATION OF PROGNOSTIC FACTORS IN PATIENTS WITH RELAPSED HODGKIN’S LYMPHOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANT
title_full	EVALUATION OF PROGNOSTIC FACTORS IN PATIENTS WITH RELAPSED HODGKIN’S LYMPHOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANT
title_fullStr	EVALUATION OF PROGNOSTIC FACTORS IN PATIENTS WITH RELAPSED HODGKIN’S LYMPHOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANT
title_full_unstemmed	EVALUATION OF PROGNOSTIC FACTORS IN PATIENTS WITH RELAPSED HODGKIN’S LYMPHOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANT
title_sort	evaluation of prognostic factors in patients with relapsed hodgkin’s lymphoma undergoing autologous stem cell transplant
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/a6666984a311421ea81f23ba7079fa44
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EVALUATION OF PROGNOSTIC FACTORS IN PATIENTS WITH RELAPSED HODGKIN’S LYMPHOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANT

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