Functionalized Nanoparticles in Prevention and Targeted Therapy of Viral Diseases With Neurotropism Properties, Special Insight on COVID-19

Neurotropic viruses have neural-invasive and neurovirulent properties to damage the central nervous system (CNS), leading to humans’ fatal symptoms. Neurotropic viruses comprise a lot of viruses, such as Zika virus (ZIKV), herpes simplex virus (HSV), rabies virus (RABV), and severe acute respiratory...

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Autores principales:	Meishen Ren, Yin Wang, Yan Luo, Xueping Yao, Zexiao Yang, Pengfei Zhang, Wei Zhao, Dike Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	neurotropic viruses SARS-CoV-2 functionalized nanoparticles drug delivery prevention targeted therapy Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a66ae0612c9d4f6a902a816dd18b14a6
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spelling	oai:doaj.org-article:a66ae0612c9d4f6a902a816dd18b14a62021-11-15T06:27:55ZFunctionalized Nanoparticles in Prevention and Targeted Therapy of Viral Diseases With Neurotropism Properties, Special Insight on COVID-191664-302X10.3389/fmicb.2021.767104https://doaj.org/article/a66ae0612c9d4f6a902a816dd18b14a62021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.767104/fullhttps://doaj.org/toc/1664-302XNeurotropic viruses have neural-invasive and neurovirulent properties to damage the central nervous system (CNS), leading to humans’ fatal symptoms. Neurotropic viruses comprise a lot of viruses, such as Zika virus (ZIKV), herpes simplex virus (HSV), rabies virus (RABV), and severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Effective therapy is needed to prevent infection by these viruses in vivo and in vitro. However, the blood-brain barrier (BBB) usually prevents macromolecules from entering the CNS, which challenges the usage of the traditional probes, antiviral drugs, or neutralizing antibodies in the CNS. Functionalized nanoparticles (NPs) have been increasingly reported in the targeted therapy of neurotropic viruses due to their sensitivity and targeting characteristics. Therefore, the present review outlines efficient functionalized NPs to further understand the recent trends, challenges, and prospects of these materials.Meishen RenYin WangYan LuoXueping YaoZexiao YangPengfei ZhangWei ZhaoDike JiangFrontiers Media S.A.articleneurotropic virusesSARS-CoV-2functionalized nanoparticlesdrug deliverypreventiontargeted therapyMicrobiologyQR1-502ENFrontiers in Microbiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neurotropic viruses SARS-CoV-2 functionalized nanoparticles drug delivery prevention targeted therapy Microbiology QR1-502
spellingShingle	neurotropic viruses SARS-CoV-2 functionalized nanoparticles drug delivery prevention targeted therapy Microbiology QR1-502 Meishen Ren Yin Wang Yan Luo Xueping Yao Zexiao Yang Pengfei Zhang Wei Zhao Dike Jiang Functionalized Nanoparticles in Prevention and Targeted Therapy of Viral Diseases With Neurotropism Properties, Special Insight on COVID-19
description	Neurotropic viruses have neural-invasive and neurovirulent properties to damage the central nervous system (CNS), leading to humans’ fatal symptoms. Neurotropic viruses comprise a lot of viruses, such as Zika virus (ZIKV), herpes simplex virus (HSV), rabies virus (RABV), and severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Effective therapy is needed to prevent infection by these viruses in vivo and in vitro. However, the blood-brain barrier (BBB) usually prevents macromolecules from entering the CNS, which challenges the usage of the traditional probes, antiviral drugs, or neutralizing antibodies in the CNS. Functionalized nanoparticles (NPs) have been increasingly reported in the targeted therapy of neurotropic viruses due to their sensitivity and targeting characteristics. Therefore, the present review outlines efficient functionalized NPs to further understand the recent trends, challenges, and prospects of these materials.
format	article
author	Meishen Ren Yin Wang Yan Luo Xueping Yao Zexiao Yang Pengfei Zhang Wei Zhao Dike Jiang
author_facet	Meishen Ren Yin Wang Yan Luo Xueping Yao Zexiao Yang Pengfei Zhang Wei Zhao Dike Jiang
author_sort	Meishen Ren
title	Functionalized Nanoparticles in Prevention and Targeted Therapy of Viral Diseases With Neurotropism Properties, Special Insight on COVID-19
title_short	Functionalized Nanoparticles in Prevention and Targeted Therapy of Viral Diseases With Neurotropism Properties, Special Insight on COVID-19
title_full	Functionalized Nanoparticles in Prevention and Targeted Therapy of Viral Diseases With Neurotropism Properties, Special Insight on COVID-19
title_fullStr	Functionalized Nanoparticles in Prevention and Targeted Therapy of Viral Diseases With Neurotropism Properties, Special Insight on COVID-19
title_full_unstemmed	Functionalized Nanoparticles in Prevention and Targeted Therapy of Viral Diseases With Neurotropism Properties, Special Insight on COVID-19
title_sort	functionalized nanoparticles in prevention and targeted therapy of viral diseases with neurotropism properties, special insight on covid-19
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a66ae0612c9d4f6a902a816dd18b14a6
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Functionalized Nanoparticles in Prevention and Targeted Therapy of Viral Diseases With Neurotropism Properties, Special Insight on COVID-19

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