Lithium promotes recovery after spinal cord injury

Lithium is associated with oxidative stress and apoptosis, but the mechanism by which lithium protects against spinal cord injury remains poorly understood. In this study, we found that intraperitoneal administration of lithium chloride (LiCl) in a rat model of spinal cord injury alleviated patholog...

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Autores principales:	Ying-Jie Zhao, Hao Qiao, Dong-Fan Liu, Jie Li, Jia-Xi Li, Su-E Chang, Teng Lu, Feng-Tao Li, Dong Wang, Hao-Peng Li, Xi-Jing He, Fang Wang
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2022
Materias:	anti-inflammatory; anti-oxidant; anti-pyroptosis; cell death; inflammatory factors; lithium; neurons; neuroprotective; nrf2/ho-1; spinal cord injury Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a66cd9b3f96043eab6fad535f94a1bda
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spelling	oai:doaj.org-article:a66cd9b3f96043eab6fad535f94a1bda2021-11-19T12:16:44ZLithium promotes recovery after spinal cord injury1673-537410.4103/1673-5374.327348https://doaj.org/article/a66cd9b3f96043eab6fad535f94a1bda2022-01-01T00:00:00Zhttp://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=6;spage=1324;epage=1333;aulast=Zhaohttps://doaj.org/toc/1673-5374Lithium is associated with oxidative stress and apoptosis, but the mechanism by which lithium protects against spinal cord injury remains poorly understood. In this study, we found that intraperitoneal administration of lithium chloride (LiCl) in a rat model of spinal cord injury alleviated pathological spinal cord injury and inhibited expression of tumor necrosis factor α, interleukin-6, and interleukin 1 β. Lithium inhibited pyroptosis and reduced inflammation by inhibiting Caspase-1 expression, reducing the oxidative stress response, and inhibiting activation of the Nod-like receptor protein 3 inflammasome. We also investigated the neuroprotective effects of lithium intervention on oxygen/glucose-deprived PC12 cells. We found that lithium reduced inflammation, oxidative damage, apoptosis, and necrosis and up-regulated nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1 in PC12 cells. All-trans retinoic acid, an Nrf2 inhibitor, reversed the effects of lithium. These results suggest that lithium exerts anti-inflammatory, anti-oxidant, and anti-pyroptotic effects through the Nrf2/heme oxygenase-1 pathway to promote recovery after spinal cord injury. This study was approved by the Animal Ethics Committee of Xi’an Jiaotong University (approval No. 2018-2053) on October 23, 2018.Ying-Jie ZhaoHao QiaoDong-Fan LiuJie LiJia-Xi LiSu-E ChangTeng LuFeng-Tao LiDong WangHao-Peng LiXi-Jing HeFang WangWolters Kluwer Medknow Publicationsarticleanti-inflammatory; anti-oxidant; anti-pyroptosis; cell death; inflammatory factors; lithium; neurons; neuroprotective; nrf2/ho-1; spinal cord injuryNeurology. Diseases of the nervous systemRC346-429ENNeural Regeneration Research, Vol 17, Iss 6, Pp 1324-1333 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-inflammatory; anti-oxidant; anti-pyroptosis; cell death; inflammatory factors; lithium; neurons; neuroprotective; nrf2/ho-1; spinal cord injury Neurology. Diseases of the nervous system RC346-429
spellingShingle	anti-inflammatory; anti-oxidant; anti-pyroptosis; cell death; inflammatory factors; lithium; neurons; neuroprotective; nrf2/ho-1; spinal cord injury Neurology. Diseases of the nervous system RC346-429 Ying-Jie Zhao Hao Qiao Dong-Fan Liu Jie Li Jia-Xi Li Su-E Chang Teng Lu Feng-Tao Li Dong Wang Hao-Peng Li Xi-Jing He Fang Wang Lithium promotes recovery after spinal cord injury
description	Lithium is associated with oxidative stress and apoptosis, but the mechanism by which lithium protects against spinal cord injury remains poorly understood. In this study, we found that intraperitoneal administration of lithium chloride (LiCl) in a rat model of spinal cord injury alleviated pathological spinal cord injury and inhibited expression of tumor necrosis factor α, interleukin-6, and interleukin 1 β. Lithium inhibited pyroptosis and reduced inflammation by inhibiting Caspase-1 expression, reducing the oxidative stress response, and inhibiting activation of the Nod-like receptor protein 3 inflammasome. We also investigated the neuroprotective effects of lithium intervention on oxygen/glucose-deprived PC12 cells. We found that lithium reduced inflammation, oxidative damage, apoptosis, and necrosis and up-regulated nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1 in PC12 cells. All-trans retinoic acid, an Nrf2 inhibitor, reversed the effects of lithium. These results suggest that lithium exerts anti-inflammatory, anti-oxidant, and anti-pyroptotic effects through the Nrf2/heme oxygenase-1 pathway to promote recovery after spinal cord injury. This study was approved by the Animal Ethics Committee of Xi’an Jiaotong University (approval No. 2018-2053) on October 23, 2018.
format	article
author	Ying-Jie Zhao Hao Qiao Dong-Fan Liu Jie Li Jia-Xi Li Su-E Chang Teng Lu Feng-Tao Li Dong Wang Hao-Peng Li Xi-Jing He Fang Wang
author_facet	Ying-Jie Zhao Hao Qiao Dong-Fan Liu Jie Li Jia-Xi Li Su-E Chang Teng Lu Feng-Tao Li Dong Wang Hao-Peng Li Xi-Jing He Fang Wang
author_sort	Ying-Jie Zhao
title	Lithium promotes recovery after spinal cord injury
title_short	Lithium promotes recovery after spinal cord injury
title_full	Lithium promotes recovery after spinal cord injury
title_fullStr	Lithium promotes recovery after spinal cord injury
title_full_unstemmed	Lithium promotes recovery after spinal cord injury
title_sort	lithium promotes recovery after spinal cord injury
publisher	Wolters Kluwer Medknow Publications
publishDate	2022
url	https://doaj.org/article/a66cd9b3f96043eab6fad535f94a1bda
work_keys_str_mv	AT yingjiezhao lithiumpromotesrecoveryafterspinalcordinjury AT haoqiao lithiumpromotesrecoveryafterspinalcordinjury AT dongfanliu lithiumpromotesrecoveryafterspinalcordinjury AT jieli lithiumpromotesrecoveryafterspinalcordinjury AT jiaxili lithiumpromotesrecoveryafterspinalcordinjury AT suechang lithiumpromotesrecoveryafterspinalcordinjury AT tenglu lithiumpromotesrecoveryafterspinalcordinjury AT fengtaoli lithiumpromotesrecoveryafterspinalcordinjury AT dongwang lithiumpromotesrecoveryafterspinalcordinjury AT haopengli lithiumpromotesrecoveryafterspinalcordinjury AT xijinghe lithiumpromotesrecoveryafterspinalcordinjury AT fangwang lithiumpromotesrecoveryafterspinalcordinjury
_version_	1718420088403525632

Lithium promotes recovery after spinal cord injury

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