The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function

The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function

Mitochondrial cristae shape influences apoptosis and respiration. Here the authors show that the mitochondrial fusion protein OPA1 protects mitochondria from dysfunction by promoting ATP synthase oligomerization and reversal activity.

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Autores principales: Rubén Quintana-Cabrera, Charlotte Quirin, Christina Glytsou, Mauro Corrado, Andrea Urbani, Anna Pellattiero, Enrique Calvo, Jesús Vázquez, José Antonio Enríquez, Christoph Gerle, María Eugenia Soriano, Paolo Bernardi, Luca Scorrano
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
Q
Acceso en línea:https://doaj.org/article/a66df5bbbc5c4ae5970022ce8e2ac008
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spelling oai:doaj.org-article:a66df5bbbc5c4ae5970022ce8e2ac0082021-12-02T16:49:53ZThe cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function10.1038/s41467-018-05655-x2041-1723https://doaj.org/article/a66df5bbbc5c4ae5970022ce8e2ac0082018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05655-xhttps://doaj.org/toc/2041-1723Mitochondrial cristae shape influences apoptosis and respiration. Here the authors show that the mitochondrial fusion protein OPA1 protects mitochondria from dysfunction by promoting ATP synthase oligomerization and reversal activity.Rubén Quintana-CabreraCharlotte QuirinChristina GlytsouMauro CorradoAndrea UrbaniAnna PellattieroEnrique CalvoJesús VázquezJosé Antonio EnríquezChristoph GerleMaría Eugenia SorianoPaolo BernardiLuca ScorranoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Rubén Quintana-Cabrera
Charlotte Quirin
Christina Glytsou
Mauro Corrado
Andrea Urbani
Anna Pellattiero
Enrique Calvo
Jesús Vázquez
José Antonio Enríquez
Christoph Gerle
María Eugenia Soriano
Paolo Bernardi
Luca Scorrano
The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function
description Mitochondrial cristae shape influences apoptosis and respiration. Here the authors show that the mitochondrial fusion protein OPA1 protects mitochondria from dysfunction by promoting ATP synthase oligomerization and reversal activity.
format article
author Rubén Quintana-Cabrera
Charlotte Quirin
Christina Glytsou
Mauro Corrado
Andrea Urbani
Anna Pellattiero
Enrique Calvo
Jesús Vázquez
José Antonio Enríquez
Christoph Gerle
María Eugenia Soriano
Paolo Bernardi
Luca Scorrano
author_facet Rubén Quintana-Cabrera
Charlotte Quirin
Christina Glytsou
Mauro Corrado
Andrea Urbani
Anna Pellattiero
Enrique Calvo
Jesús Vázquez
José Antonio Enríquez
Christoph Gerle
María Eugenia Soriano
Paolo Bernardi
Luca Scorrano
author_sort Rubén Quintana-Cabrera
title The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function
title_short The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function
title_full The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function
title_fullStr The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function
title_full_unstemmed The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function
title_sort cristae modulator optic atrophy 1 requires mitochondrial atp synthase oligomers to safeguard mitochondrial function
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/a66df5bbbc5c4ae5970022ce8e2ac008
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