One More Disguise in the Stealth Behavior of <named-content content-type="genus-species">Streptococcus pyogenes</named-content>

ABSTRACT The ability to hide in the animal kingdom is essential for survival; the same is true for bacteria. Streptococcus pyogenes is considered one of the more successful stealth bacteria in its production of a hyaluronic acid capsule that is chemically identical to the hyaluronic acid lining huma...

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Autores principales:	Vincent A. Fischetti, James B. Dale
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a66e0e59600c4bc8b593ac19adf402d8
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spelling	oai:doaj.org-article:a66e0e59600c4bc8b593ac19adf402d82021-11-15T15:50:17ZOne More Disguise in the Stealth Behavior of <named-content content-type="genus-species">Streptococcus pyogenes</named-content>10.1128/mBio.00661-162150-7511https://doaj.org/article/a66e0e59600c4bc8b593ac19adf402d82016-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00661-16https://doaj.org/toc/2150-7511ABSTRACT The ability to hide in the animal kingdom is essential for survival; the same is true for bacteria. Streptococcus pyogenes is considered one of the more successful stealth bacteria in its production of a hyaluronic acid capsule that is chemically identical to the hyaluronic acid lining human joints. It has also acquired the capacity to enter eukaryotic cells to avoid the onslaught of the host’s immune defenses, as well as drugs. From this intracellular vantage point, it may remain dormant from days to weeks, only to cause disease again at a later time, perhaps causing a relapse in a drug-treated patient. We now learn that it is able to enter macrophages as well, enabling the Streptococcus to use this “Trojan horse” approach to be transported to distant sites in the body.Vincent A. FischettiJames B. DaleAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 3 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Vincent A. Fischetti James B. Dale One More Disguise in the Stealth Behavior of <named-content content-type="genus-species">Streptococcus pyogenes</named-content>
description	ABSTRACT The ability to hide in the animal kingdom is essential for survival; the same is true for bacteria. Streptococcus pyogenes is considered one of the more successful stealth bacteria in its production of a hyaluronic acid capsule that is chemically identical to the hyaluronic acid lining human joints. It has also acquired the capacity to enter eukaryotic cells to avoid the onslaught of the host’s immune defenses, as well as drugs. From this intracellular vantage point, it may remain dormant from days to weeks, only to cause disease again at a later time, perhaps causing a relapse in a drug-treated patient. We now learn that it is able to enter macrophages as well, enabling the Streptococcus to use this “Trojan horse” approach to be transported to distant sites in the body.
format	article
author	Vincent A. Fischetti James B. Dale
author_facet	Vincent A. Fischetti James B. Dale
author_sort	Vincent A. Fischetti
title	One More Disguise in the Stealth Behavior of <named-content content-type="genus-species">Streptococcus pyogenes</named-content>
title_short	One More Disguise in the Stealth Behavior of <named-content content-type="genus-species">Streptococcus pyogenes</named-content>
title_full	One More Disguise in the Stealth Behavior of <named-content content-type="genus-species">Streptococcus pyogenes</named-content>
title_fullStr	One More Disguise in the Stealth Behavior of <named-content content-type="genus-species">Streptococcus pyogenes</named-content>
title_full_unstemmed	One More Disguise in the Stealth Behavior of <named-content content-type="genus-species">Streptococcus pyogenes</named-content>
title_sort	one more disguise in the stealth behavior of <named-content content-type="genus-species">streptococcus pyogenes</named-content>
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/a66e0e59600c4bc8b593ac19adf402d8
work_keys_str_mv	AT vincentafischetti onemoredisguiseinthestealthbehaviorofnamedcontentcontenttypegenusspeciesstreptococcuspyogenesnamedcontent AT jamesbdale onemoredisguiseinthestealthbehaviorofnamedcontentcontenttypegenusspeciesstreptococcuspyogenesnamedcontent
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One More Disguise in the Stealth Behavior of <named-content content-type="genus-species">Streptococcus pyogenes</named-content>

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