Histocompatibility of dental restorative composite resin photopolymerized with a novel multifunctional comonomer: A histopathological analysis in rats

Background: Restorative dentistry is impossible without composite resins. Toxicity of these resins is common though possessing favorable properties. Modifications of the resin matrix are being executed to improve the properties of the material. Dipentaerythritol penta-/hexa-acrylate (DPEPHA) monomer...

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Autores principales:	Jambai Sampathkumar Sivakumar, Ranganathan Ajay, Karuppiah Gokulapriyan, Natesan Thangaraj Deepa, Subramaniam Kalaiyarasu Vigneshwari, Shafie Ahamed
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	comonomer composite resin cross-link histopathology inflammation Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
Acceso en línea:	https://doaj.org/article/a670328017894250801e7ee1a531c14b
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spelling	oai:doaj.org-article:a670328017894250801e7ee1a531c14b2021-11-19T12:15:52ZHistocompatibility of dental restorative composite resin photopolymerized with a novel multifunctional comonomer: A histopathological analysis in rats0975-740610.4103/jpbs.jpbs_203_21https://doaj.org/article/a670328017894250801e7ee1a531c14b2021-01-01T00:00:00Zhttp://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=1124;epage=1130;aulast=Sivakumarhttps://doaj.org/toc/0975-7406Background: Restorative dentistry is impossible without composite resins. Toxicity of these resins is common though possessing favorable properties. Modifications of the resin matrix are being executed to improve the properties of the material. Dipentaerythritol penta-/hexa-acrylate (DPEPHA) monomer has been recently identified as a cross-linking comonomer with the conventional resin matrix. Purpose: This study aimed to investigate the histocompatibility of DPEPHA comonomer in photopolymerized resin at 20 and 40 wt.% concentrations in rats. Materials and Methods: Eighteen male Wister rats were subjected to subcutaneous implantation of conventional resin specimens without DPEPHA (G0) and with DPEPHA at 20 wt.% (G20) and 40 wt.% (G40) concentrations. Then, the rats were subdivided according to the time of resection of the implantation sites at 1, 2, and 4 weeks (n = 6 rats). Tissue specimens were submitted to histopathological analysis. Results: Except for 4 weeks' time interval, there were significant differences (P < 0.05) in the inflammation among the groups at each time interval. The order of inflammation was NC <G40 ≤G20 <G0. Concerning the fibrous capsule thickness, significant difference existed among the groups at each time interval and within the groups at all 3 time intervals (P < 0.05). Conclusion: Composite resin specimens with DPEPHA comonomer exhibited good histocompatibility in rats at 40 wt.% concentration.Jambai Sampathkumar SivakumarRanganathan AjayKaruppiah GokulapriyanNatesan Thangaraj DeepaSubramaniam Kalaiyarasu VigneshwariShafie AhamedWolters Kluwer Medknow Publicationsarticlecomonomercomposite resincross-linkhistopathologyinflammationPharmacy and materia medicaRS1-441Analytical chemistryQD71-142ENJournal of Pharmacy and Bioallied Sciences, Vol 13, Iss 6, Pp 1124-1130 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	comonomer composite resin cross-link histopathology inflammation Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
spellingShingle	comonomer composite resin cross-link histopathology inflammation Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142 Jambai Sampathkumar Sivakumar Ranganathan Ajay Karuppiah Gokulapriyan Natesan Thangaraj Deepa Subramaniam Kalaiyarasu Vigneshwari Shafie Ahamed Histocompatibility of dental restorative composite resin photopolymerized with a novel multifunctional comonomer: A histopathological analysis in rats
description	Background: Restorative dentistry is impossible without composite resins. Toxicity of these resins is common though possessing favorable properties. Modifications of the resin matrix are being executed to improve the properties of the material. Dipentaerythritol penta-/hexa-acrylate (DPEPHA) monomer has been recently identified as a cross-linking comonomer with the conventional resin matrix. Purpose: This study aimed to investigate the histocompatibility of DPEPHA comonomer in photopolymerized resin at 20 and 40 wt.% concentrations in rats. Materials and Methods: Eighteen male Wister rats were subjected to subcutaneous implantation of conventional resin specimens without DPEPHA (G0) and with DPEPHA at 20 wt.% (G20) and 40 wt.% (G40) concentrations. Then, the rats were subdivided according to the time of resection of the implantation sites at 1, 2, and 4 weeks (n = 6 rats). Tissue specimens were submitted to histopathological analysis. Results: Except for 4 weeks' time interval, there were significant differences (P < 0.05) in the inflammation among the groups at each time interval. The order of inflammation was NC <G40 ≤G20 <G0. Concerning the fibrous capsule thickness, significant difference existed among the groups at each time interval and within the groups at all 3 time intervals (P < 0.05). Conclusion: Composite resin specimens with DPEPHA comonomer exhibited good histocompatibility in rats at 40 wt.% concentration.
format	article
author	Jambai Sampathkumar Sivakumar Ranganathan Ajay Karuppiah Gokulapriyan Natesan Thangaraj Deepa Subramaniam Kalaiyarasu Vigneshwari Shafie Ahamed
author_facet	Jambai Sampathkumar Sivakumar Ranganathan Ajay Karuppiah Gokulapriyan Natesan Thangaraj Deepa Subramaniam Kalaiyarasu Vigneshwari Shafie Ahamed
author_sort	Jambai Sampathkumar Sivakumar
title	Histocompatibility of dental restorative composite resin photopolymerized with a novel multifunctional comonomer: A histopathological analysis in rats
title_short	Histocompatibility of dental restorative composite resin photopolymerized with a novel multifunctional comonomer: A histopathological analysis in rats
title_full	Histocompatibility of dental restorative composite resin photopolymerized with a novel multifunctional comonomer: A histopathological analysis in rats
title_fullStr	Histocompatibility of dental restorative composite resin photopolymerized with a novel multifunctional comonomer: A histopathological analysis in rats
title_full_unstemmed	Histocompatibility of dental restorative composite resin photopolymerized with a novel multifunctional comonomer: A histopathological analysis in rats
title_sort	histocompatibility of dental restorative composite resin photopolymerized with a novel multifunctional comonomer: a histopathological analysis in rats
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/a670328017894250801e7ee1a531c14b
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Histocompatibility of dental restorative composite resin photopolymerized with a novel multifunctional comonomer: A histopathological analysis in rats

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