Genes associated with Alzheimer's disease: an overview and current status

Genes associated with Alzheimer's disease: an overview and current status

Mohan Giri, Man Zhang, Yang Lü Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, People’s Republic of China Abstract: Alzheimer’s disease (AD) is a progressive, neurodegenerative disease and the most c...

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Autores principales: Giri M, Zhang M, Lü Y
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2016
Materias:
Alzheimer disease
Amyloid precursor protein
Genome wide association studies
Biological pathways
Presenilin 1
Presenilin 2
Neuropathology
Geriatrics
RC952-954.6
Acceso en línea:https://doaj.org/article/a6733414e6914da89f2895a440fe667f
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spelling oai:doaj.org-article:a6733414e6914da89f2895a440fe667f2021-12-02T02:40:08ZGenes associated with Alzheimer's disease: an overview and current status1178-1998https://doaj.org/article/a6733414e6914da89f2895a440fe667f2016-05-01T00:00:00Zhttps://www.dovepress.com/genes-associated-with-alzheimer39s-disease-an-overview-and-current-sta-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Mohan Giri, Man Zhang, Yang Lü Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, People’s Republic of China Abstract: Alzheimer’s disease (AD) is a progressive, neurodegenerative disease and the most common form of dementia in elderly people. It is an emerging public health problem that poses a huge societal burden. Linkage analysis was the first milestone in unraveling the mutations in APP, PSEN1, and PSEN2 that cause early-onset AD, followed by the discovery of apolipoprotein E-ε4 allele as the only one genetic risk factor for late-onset AD. Genome-wide association studies have revolutionized genetic research and have identified over 20 genetic loci associated with late-onset AD. Recently, next-generation sequencing technologies have enabled the identification of rare disease variants, including unmasking small mutations with intermediate risk of AD in PLD3, TREM2, UNC5C, AKAP9, and ADAM10. This review provides an overview of the genetic basis of AD and the relationship between these risk genes and the neuropathologic features of AD. An understanding of genetic mechanisms underlying AD pathogenesis and the potentially implicated pathways will lead to the development of novel treatment for this devastating disease. Keywords: Alzheimer’s disease, amyloid precursor protein, genome-wide association studies, biological pathways, presenilin 1, presenilin 2, neuropathologyGiri MZhang MLü YDove Medical PressarticleAlzheimer diseaseAmyloid precursor proteinGenome wide association studiesBiological pathwaysPresenilin 1Presenilin 2NeuropathologyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 665-681 (2016)
institution DOAJ
collection DOAJ
language EN
topic Alzheimer disease
Amyloid precursor protein
Genome wide association studies
Biological pathways
Presenilin 1
Presenilin 2
Neuropathology
Geriatrics
RC952-954.6
spellingShingle Alzheimer disease
Amyloid precursor protein
Genome wide association studies
Biological pathways
Presenilin 1
Presenilin 2
Neuropathology
Geriatrics
RC952-954.6
Giri M
Zhang M
Lü Y
Genes associated with Alzheimer's disease: an overview and current status
description Mohan Giri, Man Zhang, Yang Lü Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, People’s Republic of China Abstract: Alzheimer’s disease (AD) is a progressive, neurodegenerative disease and the most common form of dementia in elderly people. It is an emerging public health problem that poses a huge societal burden. Linkage analysis was the first milestone in unraveling the mutations in APP, PSEN1, and PSEN2 that cause early-onset AD, followed by the discovery of apolipoprotein E-ε4 allele as the only one genetic risk factor for late-onset AD. Genome-wide association studies have revolutionized genetic research and have identified over 20 genetic loci associated with late-onset AD. Recently, next-generation sequencing technologies have enabled the identification of rare disease variants, including unmasking small mutations with intermediate risk of AD in PLD3, TREM2, UNC5C, AKAP9, and ADAM10. This review provides an overview of the genetic basis of AD and the relationship between these risk genes and the neuropathologic features of AD. An understanding of genetic mechanisms underlying AD pathogenesis and the potentially implicated pathways will lead to the development of novel treatment for this devastating disease. Keywords: Alzheimer’s disease, amyloid precursor protein, genome-wide association studies, biological pathways, presenilin 1, presenilin 2, neuropathology
format article
author Giri M
Zhang M
Lü Y
author_facet Giri M
Zhang M
Lü Y
author_sort Giri M
title Genes associated with Alzheimer's disease: an overview and current status
title_short Genes associated with Alzheimer's disease: an overview and current status
title_full Genes associated with Alzheimer's disease: an overview and current status
title_fullStr Genes associated with Alzheimer's disease: an overview and current status
title_full_unstemmed Genes associated with Alzheimer's disease: an overview and current status
title_sort genes associated with alzheimer's disease: an overview and current status
publisher Dove Medical Press
publishDate 2016
url https://doaj.org/article/a6733414e6914da89f2895a440fe667f
work_keys_str_mv AT girim genesassociatedwithalzheimer39sdiseaseanoverviewandcurrentstatus
AT zhangm genesassociatedwithalzheimer39sdiseaseanoverviewandcurrentstatus
AT luy genesassociatedwithalzheimer39sdiseaseanoverviewandcurrentstatus
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