An update on the pharmacological treatment of anxiety and related disorders

The anxiety disorders, obsessive compulsive disorder (OCD) and post-traumatic stress disorder (PTSD) are common and debilitating, often coexist with medical and psychiatric conditions, and usually require long-term treatment. Effective anxiolytic drugs include the selective serotonin reuptake inhibi...

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Autor principal:	K. Outhoff
Formato:	article
Lenguaje:	EN
Publicado:	AOSIS 2016
Materias:	anxiety disorders obsessive-compulsive disorder post-traumatic stress disorder anxiolytics Medicine R
Acceso en línea:	https://doaj.org/article/a67476d94005433d98793d6318dc4775
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spelling	oai:doaj.org-article:a67476d94005433d98793d6318dc47752021-11-24T07:44:19ZAn update on the pharmacological treatment of anxiety and related disorders2078-61902078-620410.4102/safp.v58i5.4561https://doaj.org/article/a67476d94005433d98793d6318dc47752016-11-01T00:00:00Zhttps://safpj.co.za/index.php/safpj/article/view/4561https://doaj.org/toc/2078-6190https://doaj.org/toc/2078-6204The anxiety disorders, obsessive compulsive disorder (OCD) and post-traumatic stress disorder (PTSD) are common and debilitating, often coexist with medical and psychiatric conditions, and usually require long-term treatment. Effective anxiolytic drugs include the selective serotonin reuptake inhibitors (SSRIs) and the serotonin and noradrenaline reuptake inhibitors (SNRIs), which are the preferred agents in primary care. Patients who fail to respond adequately to these may benefit from second-line tricyclic antidepressants (TCAs) or monoamine oxidase inhibitors (MAOIs). Alternative antidepressants include agomelatine and mirtazapine. Benzodiazepines, the anti-epileptic agent, pregabalin, and atypical antipsychotics are generally reserved for specialist use. The 5-HT1A agonist, buspirone, and the antihistamine, hydroxyzine, may also be useful, although the evidence for their efficacy covers a very narrow spectrum. This review describes the pharmacology of these anxiolytics and provides updated evidence for their use in the anxiety and related disorders.K. OuthoffAOSISarticleanxiety disordersobsessive-compulsive disorderpost-traumatic stress disorderanxiolyticsMedicineRENSouth African Family Practice, Vol 58, Iss 5, Pp 50-56 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	anxiety disorders obsessive-compulsive disorder post-traumatic stress disorder anxiolytics Medicine R
spellingShingle	anxiety disorders obsessive-compulsive disorder post-traumatic stress disorder anxiolytics Medicine R K. Outhoff An update on the pharmacological treatment of anxiety and related disorders
description	The anxiety disorders, obsessive compulsive disorder (OCD) and post-traumatic stress disorder (PTSD) are common and debilitating, often coexist with medical and psychiatric conditions, and usually require long-term treatment. Effective anxiolytic drugs include the selective serotonin reuptake inhibitors (SSRIs) and the serotonin and noradrenaline reuptake inhibitors (SNRIs), which are the preferred agents in primary care. Patients who fail to respond adequately to these may benefit from second-line tricyclic antidepressants (TCAs) or monoamine oxidase inhibitors (MAOIs). Alternative antidepressants include agomelatine and mirtazapine. Benzodiazepines, the anti-epileptic agent, pregabalin, and atypical antipsychotics are generally reserved for specialist use. The 5-HT1A agonist, buspirone, and the antihistamine, hydroxyzine, may also be useful, although the evidence for their efficacy covers a very narrow spectrum. This review describes the pharmacology of these anxiolytics and provides updated evidence for their use in the anxiety and related disorders.
format	article
author	K. Outhoff
author_facet	K. Outhoff
author_sort	K. Outhoff
title	An update on the pharmacological treatment of anxiety and related disorders
title_short	An update on the pharmacological treatment of anxiety and related disorders
title_full	An update on the pharmacological treatment of anxiety and related disorders
title_fullStr	An update on the pharmacological treatment of anxiety and related disorders
title_full_unstemmed	An update on the pharmacological treatment of anxiety and related disorders
title_sort	update on the pharmacological treatment of anxiety and related disorders
publisher	AOSIS
publishDate	2016
url	https://doaj.org/article/a67476d94005433d98793d6318dc4775
work_keys_str_mv	AT kouthoff anupdateonthepharmacologicaltreatmentofanxietyandrelateddisorders AT kouthoff updateonthepharmacologicaltreatmentofanxietyandrelateddisorders
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An update on the pharmacological treatment of anxiety and related disorders

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