BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice

Chronic pancreatitis is linked with an increased risk of pancreatic cancer. Here the authors show that genomic instability due to the loss of BRCA1 associated protein-1, frequently observed in patients with pancreatic cancer, is associated with chronic pancreatitis and predisposes to cancer developm...

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Autores principales:	Stephanie Perkail, Jaclyn Andricovich, Yan Kai, Alexandros Tzatsos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a67a5dd4c14849d2a389e9a68040dda2
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spelling	oai:doaj.org-article:a67a5dd4c14849d2a389e9a68040dda22021-12-02T16:04:34ZBAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice10.1038/s41467-020-16589-82041-1723https://doaj.org/article/a67a5dd4c14849d2a389e9a68040dda22020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16589-8https://doaj.org/toc/2041-1723Chronic pancreatitis is linked with an increased risk of pancreatic cancer. Here the authors show that genomic instability due to the loss of BRCA1 associated protein-1, frequently observed in patients with pancreatic cancer, is associated with chronic pancreatitis and predisposes to cancer development.Stephanie PerkailJaclyn AndricovichYan KaiAlexandros TzatsosNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephanie Perkail Jaclyn Andricovich Yan Kai Alexandros Tzatsos BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice
description	Chronic pancreatitis is linked with an increased risk of pancreatic cancer. Here the authors show that genomic instability due to the loss of BRCA1 associated protein-1, frequently observed in patients with pancreatic cancer, is associated with chronic pancreatitis and predisposes to cancer development.
format	article
author	Stephanie Perkail Jaclyn Andricovich Yan Kai Alexandros Tzatsos
author_facet	Stephanie Perkail Jaclyn Andricovich Yan Kai Alexandros Tzatsos
author_sort	Stephanie Perkail
title	BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice
title_short	BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice
title_full	BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice
title_fullStr	BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice
title_full_unstemmed	BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice
title_sort	bap1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a67a5dd4c14849d2a389e9a68040dda2
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BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice

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