Evaluation of platelet indices and count in patients with ischemic heart disease compared to normal population

Background and Objective: Atherosclerosis and its complications are a major cause of ischemic heart diseases. Platelets play an important role in initiation of atherosclerosis and coronary thrombus formation. Large platelets are shown to be hemostatically more active. Evaluation of platelet volume p...

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Autores principales:	SH Shafaei, M Saravi, M Sharbat Daran, K Hajian, N Mesbah
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2005
Materias:	platelet indices unstable angina chronic stable angina mean platelet volume Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a67a68bf3c0e46e1b3212cd6677ef327
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spelling	oai:doaj.org-article:a67a68bf3c0e46e1b3212cd6677ef3272021-11-10T09:14:32ZEvaluation of platelet indices and count in patients with ischemic heart disease compared to normal population1561-41072251-7170https://doaj.org/article/a67a68bf3c0e46e1b3212cd6677ef3272005-04-01T00:00:00Zhttp://jbums.org/article-1-2637-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Background and Objective: Atherosclerosis and its complications are a major cause of ischemic heart diseases. Platelets play an important role in initiation of atherosclerosis and coronary thrombus formation. Large platelets are shown to be hemostatically more active. Evaluation of platelet volume parameters could be useful and significant in prediction and differentiation of coronary events. Methods: In this study, 100 patients with chest pain were divided into 3 groups according to clinical manifestation and standard diagnostic criteria. 25 patients were with unstable angina, 25 patients with chronic stable angina and 50 patients with non-cardiac chest pain as normal population. Platelet indices and count were assayed within 1 to 3 hours, after sampling from venous blood and collection in K3 EDTA, by a Sysmex KX21 analyzer. Data were provided for each group and surveyed by ANOVA and Tukey tests with Pearson correlation and P-value less than 0.05. Findings: Patients with unstable angina had a significant higher MPV (Mean platelet volume) (10.7±0.23 fl), PDW (Platelet distribution width) and PLCR (Platelet-lerge cell ratio) than those in chronic stable angina and normal group (P<0.05). MPV in chronic stable angina patients (10.1±0.2 fl) was higher than normal population (9.5±0.1 fl) but platelet count and other indices were not statistically significant difference. There were no sex or age differences in MPV amounts in population group. Conclusion: Platelet volume indices are increased in unstable angina probably because of platelet activation and a compensatory volume enhancement. Platelets count reduction in this condition results from platelet consumption. These changes in platelet count and volume could differentiate unstable angina patients from chronic stable patients and normal individuals.SH ShafaeiM SaraviM Sharbat DaranK HajianN MesbahBabol University of Medical Sciencesarticleplatelet indicesunstable anginachronic stable anginamean platelet volumeMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 7, Iss 2, Pp 48-54 (2005)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	platelet indices unstable angina chronic stable angina mean platelet volume Medicine R Medicine (General) R5-920
spellingShingle	platelet indices unstable angina chronic stable angina mean platelet volume Medicine R Medicine (General) R5-920 SH Shafaei M Saravi M Sharbat Daran K Hajian N Mesbah Evaluation of platelet indices and count in patients with ischemic heart disease compared to normal population
description	Background and Objective: Atherosclerosis and its complications are a major cause of ischemic heart diseases. Platelets play an important role in initiation of atherosclerosis and coronary thrombus formation. Large platelets are shown to be hemostatically more active. Evaluation of platelet volume parameters could be useful and significant in prediction and differentiation of coronary events. Methods: In this study, 100 patients with chest pain were divided into 3 groups according to clinical manifestation and standard diagnostic criteria. 25 patients were with unstable angina, 25 patients with chronic stable angina and 50 patients with non-cardiac chest pain as normal population. Platelet indices and count were assayed within 1 to 3 hours, after sampling from venous blood and collection in K3 EDTA, by a Sysmex KX21 analyzer. Data were provided for each group and surveyed by ANOVA and Tukey tests with Pearson correlation and P-value less than 0.05. Findings: Patients with unstable angina had a significant higher MPV (Mean platelet volume) (10.7±0.23 fl), PDW (Platelet distribution width) and PLCR (Platelet-lerge cell ratio) than those in chronic stable angina and normal group (P<0.05). MPV in chronic stable angina patients (10.1±0.2 fl) was higher than normal population (9.5±0.1 fl) but platelet count and other indices were not statistically significant difference. There were no sex or age differences in MPV amounts in population group. Conclusion: Platelet volume indices are increased in unstable angina probably because of platelet activation and a compensatory volume enhancement. Platelets count reduction in this condition results from platelet consumption. These changes in platelet count and volume could differentiate unstable angina patients from chronic stable patients and normal individuals.
format	article
author	SH Shafaei M Saravi M Sharbat Daran K Hajian N Mesbah
author_facet	SH Shafaei M Saravi M Sharbat Daran K Hajian N Mesbah
author_sort	SH Shafaei
title	Evaluation of platelet indices and count in patients with ischemic heart disease compared to normal population
title_short	Evaluation of platelet indices and count in patients with ischemic heart disease compared to normal population
title_full	Evaluation of platelet indices and count in patients with ischemic heart disease compared to normal population
title_fullStr	Evaluation of platelet indices and count in patients with ischemic heart disease compared to normal population
title_full_unstemmed	Evaluation of platelet indices and count in patients with ischemic heart disease compared to normal population
title_sort	evaluation of platelet indices and count in patients with ischemic heart disease compared to normal population
publisher	Babol University of Medical Sciences
publishDate	2005
url	https://doaj.org/article/a67a68bf3c0e46e1b3212cd6677ef327
work_keys_str_mv	AT shshafaei evaluationofplateletindicesandcountinpatientswithischemicheartdiseasecomparedtonormalpopulation AT msaravi evaluationofplateletindicesandcountinpatientswithischemicheartdiseasecomparedtonormalpopulation AT msharbatdaran evaluationofplateletindicesandcountinpatientswithischemicheartdiseasecomparedtonormalpopulation AT khajian evaluationofplateletindicesandcountinpatientswithischemicheartdiseasecomparedtonormalpopulation AT nmesbah evaluationofplateletindicesandcountinpatientswithischemicheartdiseasecomparedtonormalpopulation
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Evaluation of platelet indices and count in patients with ischemic heart disease compared to normal population

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