SODIUM POLYPRENYL PHOSPHATE (PHOSPRENYL) EXERTS AN IL-2-DEPENDENT RESTORATIVE EFFECT UPON IN VIVO DTH INHIBITION

Abstract. We have shown that polyprenyl phosphate (phosprenyl) competes with interleukin 2 for binding with serum γ-globulin. It was also demonstrated that phosprenyl restores delayed type hypersensitivity induced by Listeria monocytogenes, after its inhibition with a γ-globulin which binds to IL-2...

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Autores principales:	S. M. Sobolev, T. N. Nikolaeva, E. A. Grigorieva, A. V. Pronin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	γ-globulin interleukin-2 polyprenols dth listeriosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a67cad233db4442185b9784f6b3022fd
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spelling	oai:doaj.org-article:a67cad233db4442185b9784f6b3022fd2021-11-18T08:03:41ZSODIUM POLYPRENYL PHOSPHATE (PHOSPRENYL) EXERTS AN IL-2-DEPENDENT RESTORATIVE EFFECT UPON IN VIVO DTH INHIBITION1563-06252313-741X10.15789/1563-0625-2012-4-5-399-402https://doaj.org/article/a67cad233db4442185b9784f6b3022fd2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/401https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We have shown that polyprenyl phosphate (phosprenyl) competes with interleukin 2 for binding with serum γ-globulin. It was also demonstrated that phosprenyl restores delayed type hypersensitivity induced by Listeria monocytogenes, after its inhibition with a γ-globulin which binds to IL-2 and blocks its activity. A role of serum γ-globulin and Phosprenyl in regulation of IL-2-dependent processes is discussed.S. M. SobolevT. N. NikolaevaE. A. GrigorievaA. V. ProninSPb RAACIarticleγ-globulininterleukin-2polyprenolsdthlisteriosisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 4-5, Pp 399-402 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	γ-globulin interleukin-2 polyprenols dth listeriosis Immunologic diseases. Allergy RC581-607
spellingShingle	γ-globulin interleukin-2 polyprenols dth listeriosis Immunologic diseases. Allergy RC581-607 S. M. Sobolev T. N. Nikolaeva E. A. Grigorieva A. V. Pronin SODIUM POLYPRENYL PHOSPHATE (PHOSPRENYL) EXERTS AN IL-2-DEPENDENT RESTORATIVE EFFECT UPON IN VIVO DTH INHIBITION
description	Abstract. We have shown that polyprenyl phosphate (phosprenyl) competes with interleukin 2 for binding with serum γ-globulin. It was also demonstrated that phosprenyl restores delayed type hypersensitivity induced by Listeria monocytogenes, after its inhibition with a γ-globulin which binds to IL-2 and blocks its activity. A role of serum γ-globulin and Phosprenyl in regulation of IL-2-dependent processes is discussed.
format	article
author	S. M. Sobolev T. N. Nikolaeva E. A. Grigorieva A. V. Pronin
author_facet	S. M. Sobolev T. N. Nikolaeva E. A. Grigorieva A. V. Pronin
author_sort	S. M. Sobolev
title	SODIUM POLYPRENYL PHOSPHATE (PHOSPRENYL) EXERTS AN IL-2-DEPENDENT RESTORATIVE EFFECT UPON IN VIVO DTH INHIBITION
title_short	SODIUM POLYPRENYL PHOSPHATE (PHOSPRENYL) EXERTS AN IL-2-DEPENDENT RESTORATIVE EFFECT UPON IN VIVO DTH INHIBITION
title_full	SODIUM POLYPRENYL PHOSPHATE (PHOSPRENYL) EXERTS AN IL-2-DEPENDENT RESTORATIVE EFFECT UPON IN VIVO DTH INHIBITION
title_fullStr	SODIUM POLYPRENYL PHOSPHATE (PHOSPRENYL) EXERTS AN IL-2-DEPENDENT RESTORATIVE EFFECT UPON IN VIVO DTH INHIBITION
title_full_unstemmed	SODIUM POLYPRENYL PHOSPHATE (PHOSPRENYL) EXERTS AN IL-2-DEPENDENT RESTORATIVE EFFECT UPON IN VIVO DTH INHIBITION
title_sort	sodium polyprenyl phosphate (phosprenyl) exerts an il-2-dependent restorative effect upon in vivo dth inhibition
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/a67cad233db4442185b9784f6b3022fd
work_keys_str_mv	AT smsobolev sodiumpolyprenylphosphatephosprenylexertsanil2dependentrestorativeeffectuponinvivodthinhibition AT tnnikolaeva sodiumpolyprenylphosphatephosprenylexertsanil2dependentrestorativeeffectuponinvivodthinhibition AT eagrigorieva sodiumpolyprenylphosphatephosprenylexertsanil2dependentrestorativeeffectuponinvivodthinhibition AT avpronin sodiumpolyprenylphosphatephosprenylexertsanil2dependentrestorativeeffectuponinvivodthinhibition
_version_	1718422497507934208

SODIUM POLYPRENYL PHOSPHATE (PHOSPRENYL) EXERTS AN IL-2-DEPENDENT RESTORATIVE EFFECT UPON IN VIVO DTH INHIBITION

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