Temporal evolution of quantitative EEG within 3 days of birth in early preterm infants

Abstract For the premature newborn, little is known about changes in brain activity during transition to extra-uterine life. We aim to quantify these changes in relation to the longer-term maturation of the developing brain. We analysed EEG for up to 72 hours after birth from 28 infants born <32...

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Autores principales:	John M. O’Toole, Elena Pavlidis, Irina Korotchikova, Geraldine B. Boylan, Nathan J. Stevenson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a6805fa007014e33bbb6a409921252fe
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spelling	oai:doaj.org-article:a6805fa007014e33bbb6a409921252fe2021-12-02T16:08:46ZTemporal evolution of quantitative EEG within 3 days of birth in early preterm infants10.1038/s41598-019-41227-92045-2322https://doaj.org/article/a6805fa007014e33bbb6a409921252fe2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-41227-9https://doaj.org/toc/2045-2322Abstract For the premature newborn, little is known about changes in brain activity during transition to extra-uterine life. We aim to quantify these changes in relation to the longer-term maturation of the developing brain. We analysed EEG for up to 72 hours after birth from 28 infants born <32 weeks of gestation. These infants had favourable neurodevelopment at 2 years of age and were without significant neurological compromise at time of EEG monitoring. Quantitative EEG was generated using features representing EEG power, discontinuity, spectral distribution, and inter-hemispheric connectivity. We found rapid changes in cortical activity over the 3 days distinct from slower changes associated with gestational age: for many features, evolution over 1 day after birth is equivalent to approximately 1 to 2.5 weeks of maturation. Considerable changes in the EEG immediately after birth implies that postnatal adaption significantly influences cerebral activity for early preterm infants. Postnatal age, in addition to gestational age, should be considered when analysing preterm EEG within the first few days after birth.John M. O’TooleElena PavlidisIrina KorotchikovaGeraldine B. BoylanNathan J. StevensonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q John M. O’Toole Elena Pavlidis Irina Korotchikova Geraldine B. Boylan Nathan J. Stevenson Temporal evolution of quantitative EEG within 3 days of birth in early preterm infants
description	Abstract For the premature newborn, little is known about changes in brain activity during transition to extra-uterine life. We aim to quantify these changes in relation to the longer-term maturation of the developing brain. We analysed EEG for up to 72 hours after birth from 28 infants born <32 weeks of gestation. These infants had favourable neurodevelopment at 2 years of age and were without significant neurological compromise at time of EEG monitoring. Quantitative EEG was generated using features representing EEG power, discontinuity, spectral distribution, and inter-hemispheric connectivity. We found rapid changes in cortical activity over the 3 days distinct from slower changes associated with gestational age: for many features, evolution over 1 day after birth is equivalent to approximately 1 to 2.5 weeks of maturation. Considerable changes in the EEG immediately after birth implies that postnatal adaption significantly influences cerebral activity for early preterm infants. Postnatal age, in addition to gestational age, should be considered when analysing preterm EEG within the first few days after birth.
format	article
author	John M. O’Toole Elena Pavlidis Irina Korotchikova Geraldine B. Boylan Nathan J. Stevenson
author_facet	John M. O’Toole Elena Pavlidis Irina Korotchikova Geraldine B. Boylan Nathan J. Stevenson
author_sort	John M. O’Toole
title	Temporal evolution of quantitative EEG within 3 days of birth in early preterm infants
title_short	Temporal evolution of quantitative EEG within 3 days of birth in early preterm infants
title_full	Temporal evolution of quantitative EEG within 3 days of birth in early preterm infants
title_fullStr	Temporal evolution of quantitative EEG within 3 days of birth in early preterm infants
title_full_unstemmed	Temporal evolution of quantitative EEG within 3 days of birth in early preterm infants
title_sort	temporal evolution of quantitative eeg within 3 days of birth in early preterm infants
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a6805fa007014e33bbb6a409921252fe
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Temporal evolution of quantitative EEG within 3 days of birth in early preterm infants

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