Transancestral mapping and genetic load in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong ethnic and gender bias. In a transancestral genetic association study, Langefeldet al. identify 24 novel regions associated with risk to lupus and propose a cumulative hits hypothesis for loci conferring risk to SLE.
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Nature Portfolio
2017
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oai:doaj.org-article:a68227bc3ba0457486591e4743061bf92021-12-02T14:40:32ZTransancestral mapping and genetic load in systemic lupus erythematosus10.1038/ncomms160212041-1723https://doaj.org/article/a68227bc3ba0457486591e4743061bf92017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16021https://doaj.org/toc/2041-1723Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong ethnic and gender bias. In a transancestral genetic association study, Langefeldet al. identify 24 novel regions associated with risk to lupus and propose a cumulative hits hypothesis for loci conferring risk to SLE.Carl D. LangefeldHannah C. AinsworthDeborah S. Cunninghame GrahamJennifer A. KellyMary E. ComeauMiranda C. MarionTimothy D. HowardPaula S. RamosJennifer A. CrokerDavid L. MorrisJohanna K. SandlingJonas Carlsson AlmlöfEduardo M. Acevedo-VásquezGraciela S. AlarcónAlejandra M. BabiniVicente BacaAnders A. BengtssonGuillermo A. BerbottoMarc BijlElizabeth E. BrownHermine I. BrunnerMario H. CardielLuis CatoggioRicard CerveraJorge M. Cucho-VenegasSolbritt Rantapää DahlqvistSandra D’AlfonsoBerta Martins Da SilvaIñigo de la Rúa FigueroaAndrea DoriaJeffrey C. EdbergEmőke EndreffyJorge A. Esquivel-ValerioPaul R. FortinBarry I. FreedmanJohan FrostegårdMercedes A. GarcíaIgnacio García de la TorreGary S. GilkesonDafna D. GladmanIva GunnarssonJoel M. GuthridgeJennifer L. HugginsJudith A. JamesCees G. M. KallenbergDiane L. KamenDavid R. KarpKenneth M. KaufmanLeah C. KottyanLászló KovácsHelle LaustrupBernard R. LauwerysQuan-Zhen LiMarco A. Maradiaga-CeceñaJavier MartínJoseph M. McCuneDavid R. McWilliamsJoan T. MerrillPedro MirandaJosé F. MoctezumaSwapan K. NathTimothy B. NiewoldLorena OrozcoNorberto Ortego-CentenoMichelle PetriChristian A. PineauBernardo A. Pons-EstelJanet PopePrithvi RajRosalind Ramsey-GoldmanJohn D. ReveilleLaurie P. RussellJosé M. SabioCarlos A. Aguilar-SalinasHugo R. ScherbarthRaffaella ScorzaMichael F. SeldinChristopher SjöwallElisabet SvenungssonSusan D. ThompsonSergio M. A. TolozaLennart TruedssonTeresa Tusié-LunaCarlos VasconcelosLuis M. ViláDaniel J. WallaceMichael H. WeismanJoan E. WitherTushar BhangaleJorge R. OksenbergJohn D. RiouxPeter K. GregersenAnn-Christine SyvänenLars RönnblomLindsey A. CriswellChaim O. JacobKathy L. SivilsBetty P. TsaoLaura E. SchanbergTimothy W. BehrensEarl D. SilvermanMarta E. Alarcón-RiquelmeRobert P. KimberlyJohn B. HarleyEdward K. WakelandRobert R. GrahamPatrick M. GaffneyTimothy J. VyseNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Carl D. Langefeld Hannah C. Ainsworth Deborah S. Cunninghame Graham Jennifer A. Kelly Mary E. Comeau Miranda C. Marion Timothy D. Howard Paula S. Ramos Jennifer A. Croker David L. Morris Johanna K. Sandling Jonas Carlsson Almlöf Eduardo M. Acevedo-Vásquez Graciela S. Alarcón Alejandra M. Babini Vicente Baca Anders A. Bengtsson Guillermo A. Berbotto Marc Bijl Elizabeth E. Brown Hermine I. Brunner Mario H. Cardiel Luis Catoggio Ricard Cervera Jorge M. Cucho-Venegas Solbritt Rantapää Dahlqvist Sandra D’Alfonso Berta Martins Da Silva Iñigo de la Rúa Figueroa Andrea Doria Jeffrey C. Edberg Emőke Endreffy Jorge A. Esquivel-Valerio Paul R. Fortin Barry I. Freedman Johan Frostegård Mercedes A. García Ignacio García de la Torre Gary S. Gilkeson Dafna D. Gladman Iva Gunnarsson Joel M. Guthridge Jennifer L. Huggins Judith A. James Cees G. M. Kallenberg Diane L. Kamen David R. Karp Kenneth M. Kaufman Leah C. Kottyan László Kovács Helle Laustrup Bernard R. Lauwerys Quan-Zhen Li Marco A. Maradiaga-Ceceña Javier Martín Joseph M. McCune David R. McWilliams Joan T. Merrill Pedro Miranda José F. Moctezuma Swapan K. Nath Timothy B. Niewold Lorena Orozco Norberto Ortego-Centeno Michelle Petri Christian A. Pineau Bernardo A. Pons-Estel Janet Pope Prithvi Raj Rosalind Ramsey-Goldman John D. Reveille Laurie P. Russell José M. Sabio Carlos A. Aguilar-Salinas Hugo R. Scherbarth Raffaella Scorza Michael F. Seldin Christopher Sjöwall Elisabet Svenungsson Susan D. Thompson Sergio M. A. Toloza Lennart Truedsson Teresa Tusié-Luna Carlos Vasconcelos Luis M. Vilá Daniel J. Wallace Michael H. Weisman Joan E. Wither Tushar Bhangale Jorge R. Oksenberg John D. Rioux Peter K. Gregersen Ann-Christine Syvänen Lars Rönnblom Lindsey A. Criswell Chaim O. Jacob Kathy L. Sivils Betty P. Tsao Laura E. Schanberg Timothy W. Behrens Earl D. Silverman Marta E. Alarcón-Riquelme Robert P. Kimberly John B. Harley Edward K. Wakeland Robert R. Graham Patrick M. Gaffney Timothy J. Vyse Transancestral mapping and genetic load in systemic lupus erythematosus |
| description |
Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong ethnic and gender bias. In a transancestral genetic association study, Langefeldet al. identify 24 novel regions associated with risk to lupus and propose a cumulative hits hypothesis for loci conferring risk to SLE. |
| format |
article |
| author |
Carl D. Langefeld Hannah C. Ainsworth Deborah S. Cunninghame Graham Jennifer A. Kelly Mary E. Comeau Miranda C. Marion Timothy D. Howard Paula S. Ramos Jennifer A. Croker David L. Morris Johanna K. Sandling Jonas Carlsson Almlöf Eduardo M. Acevedo-Vásquez Graciela S. Alarcón Alejandra M. Babini Vicente Baca Anders A. Bengtsson Guillermo A. Berbotto Marc Bijl Elizabeth E. Brown Hermine I. Brunner Mario H. Cardiel Luis Catoggio Ricard Cervera Jorge M. Cucho-Venegas Solbritt Rantapää Dahlqvist Sandra D’Alfonso Berta Martins Da Silva Iñigo de la Rúa Figueroa Andrea Doria Jeffrey C. Edberg Emőke Endreffy Jorge A. Esquivel-Valerio Paul R. Fortin Barry I. Freedman Johan Frostegård Mercedes A. García Ignacio García de la Torre Gary S. Gilkeson Dafna D. Gladman Iva Gunnarsson Joel M. Guthridge Jennifer L. Huggins Judith A. James Cees G. M. Kallenberg Diane L. Kamen David R. Karp Kenneth M. Kaufman Leah C. Kottyan László Kovács Helle Laustrup Bernard R. Lauwerys Quan-Zhen Li Marco A. Maradiaga-Ceceña Javier Martín Joseph M. McCune David R. McWilliams Joan T. Merrill Pedro Miranda José F. Moctezuma Swapan K. Nath Timothy B. Niewold Lorena Orozco Norberto Ortego-Centeno Michelle Petri Christian A. Pineau Bernardo A. Pons-Estel Janet Pope Prithvi Raj Rosalind Ramsey-Goldman John D. Reveille Laurie P. Russell José M. Sabio Carlos A. Aguilar-Salinas Hugo R. Scherbarth Raffaella Scorza Michael F. Seldin Christopher Sjöwall Elisabet Svenungsson Susan D. Thompson Sergio M. A. Toloza Lennart Truedsson Teresa Tusié-Luna Carlos Vasconcelos Luis M. Vilá Daniel J. Wallace Michael H. Weisman Joan E. Wither Tushar Bhangale Jorge R. Oksenberg John D. Rioux Peter K. Gregersen Ann-Christine Syvänen Lars Rönnblom Lindsey A. Criswell Chaim O. Jacob Kathy L. Sivils Betty P. Tsao Laura E. Schanberg Timothy W. Behrens Earl D. Silverman Marta E. Alarcón-Riquelme Robert P. Kimberly John B. Harley Edward K. Wakeland Robert R. Graham Patrick M. Gaffney Timothy J. Vyse |
| author_facet |
Carl D. Langefeld Hannah C. Ainsworth Deborah S. Cunninghame Graham Jennifer A. Kelly Mary E. Comeau Miranda C. Marion Timothy D. Howard Paula S. Ramos Jennifer A. Croker David L. Morris Johanna K. Sandling Jonas Carlsson Almlöf Eduardo M. Acevedo-Vásquez Graciela S. Alarcón Alejandra M. Babini Vicente Baca Anders A. Bengtsson Guillermo A. Berbotto Marc Bijl Elizabeth E. Brown Hermine I. Brunner Mario H. Cardiel Luis Catoggio Ricard Cervera Jorge M. Cucho-Venegas Solbritt Rantapää Dahlqvist Sandra D’Alfonso Berta Martins Da Silva Iñigo de la Rúa Figueroa Andrea Doria Jeffrey C. Edberg Emőke Endreffy Jorge A. Esquivel-Valerio Paul R. Fortin Barry I. Freedman Johan Frostegård Mercedes A. García Ignacio García de la Torre Gary S. Gilkeson Dafna D. Gladman Iva Gunnarsson Joel M. Guthridge Jennifer L. Huggins Judith A. James Cees G. M. Kallenberg Diane L. Kamen David R. Karp Kenneth M. Kaufman Leah C. Kottyan László Kovács Helle Laustrup Bernard R. Lauwerys Quan-Zhen Li Marco A. Maradiaga-Ceceña Javier Martín Joseph M. McCune David R. McWilliams Joan T. Merrill Pedro Miranda José F. Moctezuma Swapan K. Nath Timothy B. Niewold Lorena Orozco Norberto Ortego-Centeno Michelle Petri Christian A. Pineau Bernardo A. Pons-Estel Janet Pope Prithvi Raj Rosalind Ramsey-Goldman John D. Reveille Laurie P. Russell José M. Sabio Carlos A. Aguilar-Salinas Hugo R. Scherbarth Raffaella Scorza Michael F. Seldin Christopher Sjöwall Elisabet Svenungsson Susan D. Thompson Sergio M. A. Toloza Lennart Truedsson Teresa Tusié-Luna Carlos Vasconcelos Luis M. Vilá Daniel J. Wallace Michael H. Weisman Joan E. Wither Tushar Bhangale Jorge R. Oksenberg John D. Rioux Peter K. Gregersen Ann-Christine Syvänen Lars Rönnblom Lindsey A. Criswell Chaim O. Jacob Kathy L. Sivils Betty P. Tsao Laura E. Schanberg Timothy W. Behrens Earl D. Silverman Marta E. Alarcón-Riquelme Robert P. Kimberly John B. Harley Edward K. Wakeland Robert R. Graham Patrick M. Gaffney Timothy J. Vyse |
| author_sort |
Carl D. Langefeld |
| title |
Transancestral mapping and genetic load in systemic lupus erythematosus |
| title_short |
Transancestral mapping and genetic load in systemic lupus erythematosus |
| title_full |
Transancestral mapping and genetic load in systemic lupus erythematosus |
| title_fullStr |
Transancestral mapping and genetic load in systemic lupus erythematosus |
| title_full_unstemmed |
Transancestral mapping and genetic load in systemic lupus erythematosus |
| title_sort |
transancestral mapping and genetic load in systemic lupus erythematosus |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/a68227bc3ba0457486591e4743061bf9 |
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