Expression of osteoprotegerin in placenta and its association with preeclampsia.

<h4>Background</h4>Osteoprotegerin (OPG), a key regulatory factor in bone metabolism, was documented also a potential pro-angiogenic factor, which acts an important role in protecting vascular endothelial cells. Since preeclampsia has gradually been employed to be vascular diseases, we s...

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Autores principales:	Pei Shen, Yunhui Gong, Tao Wang, Yueyue Chen, Jin Jia, Shanshan Ni, Bin Zhou, Yapin Song, Lin Zhang, Rong Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a684c4afa22549acabd9a6885f6501c2
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spelling	oai:doaj.org-article:a684c4afa22549acabd9a6885f6501c22021-11-18T07:07:00ZExpression of osteoprotegerin in placenta and its association with preeclampsia.1932-620310.1371/journal.pone.0044340https://doaj.org/article/a684c4afa22549acabd9a6885f6501c22012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22952959/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Osteoprotegerin (OPG), a key regulatory factor in bone metabolism, was documented also a potential pro-angiogenic factor, which acts an important role in protecting vascular endothelial cells. Since preeclampsia has gradually been employed to be vascular diseases, we speculated that OPG might be associated with preeclampsia. The study was to evaluate the level of OPG protein and mRNA in placenta, and investigate the relationship between OPG and the pathogenesis of preeclampsia.<h4>Methodology/principal findings</h4>Placental specimens from 30 term normal pregnancy, 30 severe preeclampsia and 30 mild cases were studied. The expression and levels of OPGs' protein and mRNA were detected by immunohistochemistry, western blot analysis and real-time quantitative PCR analysis respectively. The expression of OPG protein was found in cytoplasm of placenta cytotrophoblasts and syncytiotrophoblasts in three groups. There were no significant differences of OPG protein between the maternal and fetal side in each group. The OPG protein and mRNA levels in severe preeclampsia were significantly higher than those in mild cases and normal pregnancy. However, there were no markedly differences of the OPG protein and mRNA levels between term delivery and preterm delivery in severe cases. In preeclampsia, the OPG protein and mRNA level was positively correlated with systolic blood pressure and 24 h urinary protein respectively.<h4>Conclusions/significance</h4>OPG protein and mRNA level in placentas of preeclampsia were found abnormal compared with normal pregnancy. In preeclampsia, the OPG protein and mRNA levels were closely related with its important clinical parameters. Taken together, OPG might be closely correlated with the pathogenesis of preeclampsia.Pei ShenYunhui GongTao WangYueyue ChenJin JiaShanshan NiBin ZhouYapin SongLin ZhangRong ZhouPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e44340 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pei Shen Yunhui Gong Tao Wang Yueyue Chen Jin Jia Shanshan Ni Bin Zhou Yapin Song Lin Zhang Rong Zhou Expression of osteoprotegerin in placenta and its association with preeclampsia.
description	<h4>Background</h4>Osteoprotegerin (OPG), a key regulatory factor in bone metabolism, was documented also a potential pro-angiogenic factor, which acts an important role in protecting vascular endothelial cells. Since preeclampsia has gradually been employed to be vascular diseases, we speculated that OPG might be associated with preeclampsia. The study was to evaluate the level of OPG protein and mRNA in placenta, and investigate the relationship between OPG and the pathogenesis of preeclampsia.<h4>Methodology/principal findings</h4>Placental specimens from 30 term normal pregnancy, 30 severe preeclampsia and 30 mild cases were studied. The expression and levels of OPGs' protein and mRNA were detected by immunohistochemistry, western blot analysis and real-time quantitative PCR analysis respectively. The expression of OPG protein was found in cytoplasm of placenta cytotrophoblasts and syncytiotrophoblasts in three groups. There were no significant differences of OPG protein between the maternal and fetal side in each group. The OPG protein and mRNA levels in severe preeclampsia were significantly higher than those in mild cases and normal pregnancy. However, there were no markedly differences of the OPG protein and mRNA levels between term delivery and preterm delivery in severe cases. In preeclampsia, the OPG protein and mRNA level was positively correlated with systolic blood pressure and 24 h urinary protein respectively.<h4>Conclusions/significance</h4>OPG protein and mRNA level in placentas of preeclampsia were found abnormal compared with normal pregnancy. In preeclampsia, the OPG protein and mRNA levels were closely related with its important clinical parameters. Taken together, OPG might be closely correlated with the pathogenesis of preeclampsia.
format	article
author	Pei Shen Yunhui Gong Tao Wang Yueyue Chen Jin Jia Shanshan Ni Bin Zhou Yapin Song Lin Zhang Rong Zhou
author_facet	Pei Shen Yunhui Gong Tao Wang Yueyue Chen Jin Jia Shanshan Ni Bin Zhou Yapin Song Lin Zhang Rong Zhou
author_sort	Pei Shen
title	Expression of osteoprotegerin in placenta and its association with preeclampsia.
title_short	Expression of osteoprotegerin in placenta and its association with preeclampsia.
title_full	Expression of osteoprotegerin in placenta and its association with preeclampsia.
title_fullStr	Expression of osteoprotegerin in placenta and its association with preeclampsia.
title_full_unstemmed	Expression of osteoprotegerin in placenta and its association with preeclampsia.
title_sort	expression of osteoprotegerin in placenta and its association with preeclampsia.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/a684c4afa22549acabd9a6885f6501c2
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Expression of osteoprotegerin in placenta and its association with preeclampsia.

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