Multiple breath washout: measuring early manifestations of lung pathology

The multiple breath washout (MBW) test measures the efficiency of gas mixing in the lungs and has gained significant interest over the past 20 years. MBW outcomes detect early lung function impairment and peripheral airway pathology, through its main outcome measure lung clearance index (LCI). LCI m...

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Autores principales:	Sanja Stanojevic, Cole Bowerman, Paul Robinson
Formato:	article
Lenguaje:	EN
Publicado:	European Respiratory Society 2021
Materias:	Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/a6885ba767e540a19c7e8a345d03f73b
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spelling	oai:doaj.org-article:a6885ba767e540a19c7e8a345d03f73b2021-11-24T07:45:28ZMultiple breath washout: measuring early manifestations of lung pathology1810-68382073-473510.1183/20734735.0016-2021https://doaj.org/article/a6885ba767e540a19c7e8a345d03f73b2021-09-01T00:00:00Zhttp://breathe.ersjournals.com/content/17/3/210016.fullhttps://doaj.org/toc/1810-6838https://doaj.org/toc/2073-4735The multiple breath washout (MBW) test measures the efficiency of gas mixing in the lungs and has gained significant interest over the past 20 years. MBW outcomes detect early lung function impairment and peripheral airway pathology, through its main outcome measure lung clearance index (LCI). LCI measures the number of lung turnovers required to washout an inert tracer gas. MBW is performed during normal (tidal) breathing, making it particularly suitable for young children or those who have trouble performing forced manoeuvres. Additionally, research in chronic respiratory disease populations has shown that MBW can detect acute clinically relevant changes before conventional lung function tests, such as spirometry, thus enabling early intervention. The development of technical standards for MBW and commercial devices have allowed MBW to be implemented in clinical research and potentially routine clinical practice. Although studies have summarised clinimetric properties of MBW indices, additional research is required to establish the clinical utility of MBW and, if possible, shorten testing time. Sensitive, feasible measures of early lung function decline will play an important role in early intervention for people living with respiratory diseases. Educational aim To describe the multiple breath washout test, its applications to lung pathology and respiratory disease, as well as directions for future research.Sanja StanojevicCole BowermanPaul RobinsonEuropean Respiratory SocietyarticleDiseases of the respiratory systemRC705-779ENBreathe, Vol 17, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the respiratory system RC705-779
spellingShingle	Diseases of the respiratory system RC705-779 Sanja Stanojevic Cole Bowerman Paul Robinson Multiple breath washout: measuring early manifestations of lung pathology
description	The multiple breath washout (MBW) test measures the efficiency of gas mixing in the lungs and has gained significant interest over the past 20 years. MBW outcomes detect early lung function impairment and peripheral airway pathology, through its main outcome measure lung clearance index (LCI). LCI measures the number of lung turnovers required to washout an inert tracer gas. MBW is performed during normal (tidal) breathing, making it particularly suitable for young children or those who have trouble performing forced manoeuvres. Additionally, research in chronic respiratory disease populations has shown that MBW can detect acute clinically relevant changes before conventional lung function tests, such as spirometry, thus enabling early intervention. The development of technical standards for MBW and commercial devices have allowed MBW to be implemented in clinical research and potentially routine clinical practice. Although studies have summarised clinimetric properties of MBW indices, additional research is required to establish the clinical utility of MBW and, if possible, shorten testing time. Sensitive, feasible measures of early lung function decline will play an important role in early intervention for people living with respiratory diseases. Educational aim To describe the multiple breath washout test, its applications to lung pathology and respiratory disease, as well as directions for future research.
format	article
author	Sanja Stanojevic Cole Bowerman Paul Robinson
author_facet	Sanja Stanojevic Cole Bowerman Paul Robinson
author_sort	Sanja Stanojevic
title	Multiple breath washout: measuring early manifestations of lung pathology
title_short	Multiple breath washout: measuring early manifestations of lung pathology
title_full	Multiple breath washout: measuring early manifestations of lung pathology
title_fullStr	Multiple breath washout: measuring early manifestations of lung pathology
title_full_unstemmed	Multiple breath washout: measuring early manifestations of lung pathology
title_sort	multiple breath washout: measuring early manifestations of lung pathology
publisher	European Respiratory Society
publishDate	2021
url	https://doaj.org/article/a6885ba767e540a19c7e8a345d03f73b
work_keys_str_mv	AT sanjastanojevic multiplebreathwashoutmeasuringearlymanifestationsoflungpathology AT colebowerman multiplebreathwashoutmeasuringearlymanifestationsoflungpathology AT paulrobinson multiplebreathwashoutmeasuringearlymanifestationsoflungpathology
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Multiple breath washout: measuring early manifestations of lung pathology

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