HDP-a novel heme detoxification protein from the malaria parasite.

When malaria parasites infect host red blood cells (RBC) and proteolyze hemoglobin, a unique, albeit poorly understood parasite-specific mechanism, detoxifies released heme into hemozoin (Hz). Here, we report the identification and characterization of a novel Plasmodium Heme Detoxification Protein (...

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Autores principales:	Dewal Jani, Rana Nagarkatti, Wandy Beatty, Ross Angel, Carla Slebodnick, John Andersen, Sanjai Kumar, Dharmendar Rathore
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a688632aec0f42dcb572510f2dc426b2
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spelling	oai:doaj.org-article:a688632aec0f42dcb572510f2dc426b22021-11-25T05:46:37ZHDP-a novel heme detoxification protein from the malaria parasite.1553-73661553-737410.1371/journal.ppat.1000053https://doaj.org/article/a688632aec0f42dcb572510f2dc426b22008-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18437218/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374When malaria parasites infect host red blood cells (RBC) and proteolyze hemoglobin, a unique, albeit poorly understood parasite-specific mechanism, detoxifies released heme into hemozoin (Hz). Here, we report the identification and characterization of a novel Plasmodium Heme Detoxification Protein (HDP) that is extremely potent in converting heme into Hz. HDP is functionally conserved across Plasmodium genus and its gene locus could not be disrupted. Once expressed, the parasite utilizes a circuitous "Outbound-Inbound" trafficking route by initially secreting HDP into the cytosol of infected RBC. A subsequent endocytosis of host cytosol (and hemoglobin) delivers HDP to the food vacuole (FV), the site of Hz formation. As Hz formation is critical for survival, involvement of HDP in this process suggests that it could be a malaria drug target.Dewal JaniRana NagarkattiWandy BeattyRoss AngelCarla SlebodnickJohn AndersenSanjai KumarDharmendar RathorePublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 4, Iss 4, p e1000053 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Dewal Jani Rana Nagarkatti Wandy Beatty Ross Angel Carla Slebodnick John Andersen Sanjai Kumar Dharmendar Rathore HDP-a novel heme detoxification protein from the malaria parasite.
description	When malaria parasites infect host red blood cells (RBC) and proteolyze hemoglobin, a unique, albeit poorly understood parasite-specific mechanism, detoxifies released heme into hemozoin (Hz). Here, we report the identification and characterization of a novel Plasmodium Heme Detoxification Protein (HDP) that is extremely potent in converting heme into Hz. HDP is functionally conserved across Plasmodium genus and its gene locus could not be disrupted. Once expressed, the parasite utilizes a circuitous "Outbound-Inbound" trafficking route by initially secreting HDP into the cytosol of infected RBC. A subsequent endocytosis of host cytosol (and hemoglobin) delivers HDP to the food vacuole (FV), the site of Hz formation. As Hz formation is critical for survival, involvement of HDP in this process suggests that it could be a malaria drug target.
format	article
author	Dewal Jani Rana Nagarkatti Wandy Beatty Ross Angel Carla Slebodnick John Andersen Sanjai Kumar Dharmendar Rathore
author_facet	Dewal Jani Rana Nagarkatti Wandy Beatty Ross Angel Carla Slebodnick John Andersen Sanjai Kumar Dharmendar Rathore
author_sort	Dewal Jani
title	HDP-a novel heme detoxification protein from the malaria parasite.
title_short	HDP-a novel heme detoxification protein from the malaria parasite.
title_full	HDP-a novel heme detoxification protein from the malaria parasite.
title_fullStr	HDP-a novel heme detoxification protein from the malaria parasite.
title_full_unstemmed	HDP-a novel heme detoxification protein from the malaria parasite.
title_sort	hdp-a novel heme detoxification protein from the malaria parasite.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/a688632aec0f42dcb572510f2dc426b2
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HDP-a novel heme detoxification protein from the malaria parasite.

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