Impact of topical bimatoprost 0.01% and bimatoprost 0.03% on conjunctival irritation in rabbits

Abayomi B Ogundele, Guangming Li, Joel J EllisAlcon Research, Ltd., Fort Worth, TX, USAIntroduction: The purpose of this study was to examine and compare the conjunctival irritation (congestion, swelling, and discharge) of topical bimatoprost ophthalmic solution 0.01% and bimatoprost ophthalmic solu...

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Autores principales:	Abayomi B Ogundele, Guangming Li, Joel J Ellis
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a68abd52cfdb43ebb358af83881faefc
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spelling	oai:doaj.org-article:a68abd52cfdb43ebb358af83881faefc2021-12-02T02:57:29ZImpact of topical bimatoprost 0.01% and bimatoprost 0.03% on conjunctival irritation in rabbits1177-54671177-5483https://doaj.org/article/a68abd52cfdb43ebb358af83881faefc2010-02-01T00:00:00Zhttp://www.dovepress.com/impact-of-topical-bimatoprost-001-and-bimatoprost-003-on-conjunctival--a3970https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Abayomi B Ogundele, Guangming Li, Joel J EllisAlcon Research, Ltd., Fort Worth, TX, USAIntroduction: The purpose of this study was to examine and compare the conjunctival irritation (congestion, swelling, and discharge) of topical bimatoprost ophthalmic solution 0.01% and bimatoprost ophthalmic solution 0.03% in rabbits.Methods: Six healthy New Zealand White rabbits were treated with either bimatoprost 0.01% or bimatoprost 0.03% (3 animals/group). One dose (2 drops/dose) of study medication was administered to the right eye of each animal every 30 minutes for 4.5 hours. Approximately 1 hour after the last dose, conjunctival irritation was assessed using a slit-lamp biomicroscope to individually evaluate conjunctival congestion, swelling, and discharge.Results: The mean conjunctival congestion, swelling and discharge scores for bimatoprost 0.03% were 1.67, 0.33 and 0.33, respectively, and for bimatoprost 0.01% were 2.00, 0.33 and 1.33, respectively.Conclusions: Despite the lower drug concentration of the 0.01% formulation, bimatoprost 0.01% does not reduce conjunctival irritation, including conjunctival congestion, swelling, and discharge, in rabbits compared to bimatoprost 0.03%. Further studies would be needed to determine whether the increase in the mean conjunctival congestion and discharge scores may be attributed to the increased BAK concentration in the bimatoprost 0.01% formulation.Keywords: bimatoprost, conjunctiva, ocular toxicity, preclinical, prostaglandin analog, rabbits Abayomi B OgundeleGuangming LiJoel J EllisDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 77-80 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Abayomi B Ogundele Guangming Li Joel J Ellis Impact of topical bimatoprost 0.01% and bimatoprost 0.03% on conjunctival irritation in rabbits
description	Abayomi B Ogundele, Guangming Li, Joel J EllisAlcon Research, Ltd., Fort Worth, TX, USAIntroduction: The purpose of this study was to examine and compare the conjunctival irritation (congestion, swelling, and discharge) of topical bimatoprost ophthalmic solution 0.01% and bimatoprost ophthalmic solution 0.03% in rabbits.Methods: Six healthy New Zealand White rabbits were treated with either bimatoprost 0.01% or bimatoprost 0.03% (3 animals/group). One dose (2 drops/dose) of study medication was administered to the right eye of each animal every 30 minutes for 4.5 hours. Approximately 1 hour after the last dose, conjunctival irritation was assessed using a slit-lamp biomicroscope to individually evaluate conjunctival congestion, swelling, and discharge.Results: The mean conjunctival congestion, swelling and discharge scores for bimatoprost 0.03% were 1.67, 0.33 and 0.33, respectively, and for bimatoprost 0.01% were 2.00, 0.33 and 1.33, respectively.Conclusions: Despite the lower drug concentration of the 0.01% formulation, bimatoprost 0.01% does not reduce conjunctival irritation, including conjunctival congestion, swelling, and discharge, in rabbits compared to bimatoprost 0.03%. Further studies would be needed to determine whether the increase in the mean conjunctival congestion and discharge scores may be attributed to the increased BAK concentration in the bimatoprost 0.01% formulation.Keywords: bimatoprost, conjunctiva, ocular toxicity, preclinical, prostaglandin analog, rabbits
format	article
author	Abayomi B Ogundele Guangming Li Joel J Ellis
author_facet	Abayomi B Ogundele Guangming Li Joel J Ellis
author_sort	Abayomi B Ogundele
title	Impact of topical bimatoprost 0.01% and bimatoprost 0.03% on conjunctival irritation in rabbits
title_short	Impact of topical bimatoprost 0.01% and bimatoprost 0.03% on conjunctival irritation in rabbits
title_full	Impact of topical bimatoprost 0.01% and bimatoprost 0.03% on conjunctival irritation in rabbits
title_fullStr	Impact of topical bimatoprost 0.01% and bimatoprost 0.03% on conjunctival irritation in rabbits
title_full_unstemmed	Impact of topical bimatoprost 0.01% and bimatoprost 0.03% on conjunctival irritation in rabbits
title_sort	impact of topical bimatoprost 0.01% and bimatoprost 0.03% on conjunctival irritation in rabbits
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/a68abd52cfdb43ebb358af83881faefc
work_keys_str_mv	AT abayomibogundele impactoftopicalbimatoprost001andbimatoprost003onconjunctivalirritationinrabbits AT guangmingli impactoftopicalbimatoprost001andbimatoprost003onconjunctivalirritationinrabbits AT joeljellis impactoftopicalbimatoprost001andbimatoprost003onconjunctivalirritationinrabbits
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Impact of topical bimatoprost 0.01% and bimatoprost 0.03% on conjunctival irritation in rabbits

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